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Biomedical subjects

P Redondo

Publications and source records attributed to P Redondo.

60 records · Page 4Linked to original sources
PubMed1992

Perianal basal cell carcinoma.

Perianal basal cell carcinoma (BCC) is a rare tumour and only a few case reports can be found in the literature. In this location, it is important to differentiate a BCC from a basaloid cloacogenic carcinoma, as the first is an invasive but localized tumour, while the second has a high capacity for metastasis.

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PubMedDate not supplied

[Update on melanoma: incidence, development and biological aspects].

Melanoma is a malign tumour, highly metastatic, that has undergone a spectacular increase in all of its clinical forms in the last 40 years, with a threefold increase in its incidence. Besides genetic predisposition, intense exposure to sunlight by light skinned patients, together with antecedents of sunburn during childhood, constitute the principal risk factor for its appearance. Many clinical and histological observations suggest a clear interaction between the immune system of the host and skin cancer. In the disease's progression, in the passage from a phase of horizontal growth to an invasive phase of vertical growth--the determinant factor in prognosis--factors intervene that are only partially understood. Angiogenesis, or the development of new vessels, is necessary to maintain the growth, invasion and metastatic capacity of a tumour. VEGF and bFGF are outstanding amongst the pro-angiogenic cytokines secreted by the skin cancer cells; these favour endothelial proliferation and the invasive capacity of the tumour. Similarly, it has been found that the presence of Th1 cytokines in the "tumourous environment" prevents the disease's progression and favours regression, while a Th2 pattern favours invasion and increases the potential for metastasis. The decline in the immune response of the host might be mediated by the synthesis of immuno-suppressor cytokines by the tumourous cells (IL-10, TGF-beta, VEGF) and by the expression on its surface of Fas-L molecules, which make skin cancer a privileged tissue from an immunological point of view.

English Abstract↗
PubMedDate not supplied

Secondary urticaria due to toxocariasis: possibly caused by ingesting raw cattle meat?

Skin affectation in patients infected by Toxocara spp. is rare even in endemic regions. We present a case of a patient that consulted us for a urticarial process and a personal history of eating rat cattle meat. After several studies, the diagnosis of secondary urticaria due to Toxocara spp. infection was made. Improvement of the symptoms was observed after treatment with thiabendazole.

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