omega-Conotoxin and ethanol produce similar actions on in vitro calcium channel functions. The present study was designed to determine their possible behavioral interaction. omega-Conotoxin injected ICV at either 0.1 microgram or 0.3 microgram, produced an increase in spontaneous and evoked tremor activity in male Sprague-Dawley rats. The tremor was present at 30 min and continued at least 4 h after injection. At 4 h post ICV injection, animals were given an IP injection of ethanol (3 g/kg body weight). Although no blood alcohol differences were observed between groups, rats injected with omega-conotoxin showed a concentration-dependent increase in sleep times: Saline controls slept for an average of 84.7 +/- 16.7 min, 0.1 and 0.3 microgram conotoxin treated animals slept for 121.3 +/- 16.2 and 211.1 +/- 30.7 min, respectively. These results extend the class of calcium channel blockers capable of producing a behavioral interaction with ethanol.

Animals↗

PubMedDate not supplied

Communication disorders in the 22Q11.2 microdeletion syndrome.

The 22q11.2 microdeletion syndrome is a genetic disorder that is being recognized with increasing frequency. Confirmation of the diagnosis can be made using fluorescence in situ hybridization. Many medical and developmental problems are present in children with this syndrome. Communication disorders are among the most common features of this syndrome and include articulation, language, resonance, and voice problems. The purpose of this paper is to provide a description of the communicative and developmental features in a sample of children with the 22q11.2 microdeletion syndrome seen for evaluation. Because communication and feeding disorders may be presenting features of this syndrome, speech and language pathologists must be familiar with this syndrome and its various characteristics. Awareness of these features and a multidisciplinary approach are necessary for the identification and treatment of the complex communicative and medical problems present in this population.

Adolescent↗

PubMedDate not supplied

Evaluation of soft palate function with MRI: application to the cleft palate patient.

Magnetic resonance imaging was employed to evaluate soft palate function in four normal volunteers and four patients with surgically repaired cleft palate, using a GE Signa clinical scanner at 1.5 T and a custom designed receive coil with a sensitivity profile encompassing from the nasopharynx to the larynx. Midsagittal images were obtained using spoiled gradient recalled acquisition at steady state while the subject phonated the following sounds: (a) MMM, (b) SSS, (c) DAH, and (d) EEE. An image at rest with normal breathing was also obtained. The soft palate and its relationship to the airway and the posterior pharyngeal wall were clearly visualized in all cases. Phonation of the prescribed sounds demonstrated the normal range of soft palate motion. The images also depicted the ability of the soft palate to divert airflow to the nasopharynx. Interpretation of functional MRI may be of value in evaluation of surgical results, guidance of speech therapy, and surgical planning in the cleft palate patient. This noninvasive alternative to conventional methods of visualization provides advantages in resolution, repeatability, and patient comfort.

Adolescent↗

PubMedDate not supplied

A stranger in the family.

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Family Health↗