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P Racz

Publications and source records attributed to P Racz.

At least 73 records · Page 4Linked to original sources
PubMed1991

[Histologic classification of HIV-1 induced lymphadenopathy. Current results on the pathogenesis of germinal center changes].

At the IV International Conference on AIDS in Stockholm, a Symposium on the pathology of HIV-related diseases was organized. During this Symposium the "European Study Group on HIV-Pathology" presented a histological classification of lymph node alterations seen in HIV-associated lymphadenopathy. The goal of the Study group was to offer a common terminology for histologic changes previously described with different terms by different authors. In the present review the most important histological criteria used in the proposed classification are summarized. Since the classification is based on the conspicuous changes of the follicles, a brief review of the possible pathogenic mechanisms leading to disintegration of the germinal centers will also be given.

AIDS-Related Complex↗
PubMed1991

Pulmonary schistosomiasis resembling acute pulmonary tuberculosis.

Pulmonary involvement of schistosomiasis is usually characterized by a miliary mottling or diffuse nodular infiltrates. In most cases, pulmonary involvement is associated with an apparent clinical involvement of other organs. This report describes a 35 yr old patient who developed a cavity, a parenchymatous infiltrate and hilar adenopathy in association with pulmonary schistosomiasis. Schistosoma eggs were demonstrated in transbronchial biopsies from the lung. Pulmonary involvement of schistosomiasis is reviewed and atypical features are discussed, which may lead to diagnostic difficulties, particularly compared to tuberculosis.

Adult↗
PubMed1990

Lymphatic tissue changes in AIDS and other retrovirus infections: tools and insights.

Based on immunohistochemistry, in situ hybridization, and electron microscopy, lymphatic tissue changes in human immunodeficiency virus (HIV) and other retroviral infections represent different stages of a dynamic process progressing from hyperplasia to atrophy. The germinal centers (GC) function early as a virus reservoir in both HIV and feline leukemia virus infection, which also produces lymphadenopathy, severe immune impairment, and death from opportunistic infections. Core proteins of HIV can be detected on the surface of follicular dendritic cells, electron microscopy reveals cell-free HIV and virus replication in the same location, and in situ hybridization shows that the majority of cells with mRNA of HIV can be found in germinal centers (GC). Double immunohistochemical labeling of lymphocyte populations suggests that one of the most important events in HIV lymphadenitis with explosive follicular hyperplasia is the accumulation of CD8+CD45R0+ lymphocytes in the lymph nodes. Their clustering in the vicinity of the FDC network could play a key role in disintegration of GC and lymphocyte depletion as the disease progresses.

Acquired Immunodeficiency Syndrome↗
PubMed1989

Effects of intradermal gamma-interferon in cutaneous leishmaniasis.

The clinical and immunological evolution of lesions in cutaneous leishmaniasis was assessed after treatment with human recombinant gamma interferon (rIFN-gamma). 3 weeks after rIFN-gamma treatment of lesions due to Leishmania braziliensis guyanensis, 12/13 had become smaller compared with 6/13 control lesions; only 4 treated lesions were free of parasites. 9 of 13 L tropica lesions treated with rIFN-gamma resolved completely within 4-8 weeks of treatment. An acute inflammatory reaction around treated lesions was more common in lesions due to L tropica. There were no other local or systemic adverse reactions. Histological and immunohistochemical studies indicate that local application of rIFN-gamma enhances cell-mediated immune responses and thus promotes healing of cutaneous leishmaniasis.

Acute Disease↗
PubMed1989

Experimental infection of rhesus monkeys with SIV isolated from African green monkeys.

To establish an animal model for AIDS, 6 juvenile rhesus monkeys were infected intravenously with cell-free SIVagmTYO-1, 5, or 7. One animal was infected with SIV of known pathogenicity isolated from a sooty mangabey (SIVsmm). The 2 animals infected with TYO-1, 1 of 2 infected with TYO-7 and the 1 infected with SIVsmm seroconverted within 4-8 weeks after infection and infectious virus could be recovered 8-10 or 44 weeks after infection. Three of the 4 seroconverted monkeys developed a persistent lymphadenopathy 12 weeks after infection. Rhesus monkeys infected with SIVagm could serve as a model to study HIV infection and for vaccine trials.

Acquired Immunodeficiency Syndrome↗
PubMed1987

HIV-infection in forensic autopsy cases.

Sudden and unexpected death and violent death of persons with a high risk of acquiring HIV-infections, especially homosexual males and intravenous drug abusers, have to be investigated by forensic autopsies. Therefore every forensic pathologist has to be aware of this infection and should try to make the proper diagnosis. Three typical cases are described: (1) suicide by hanging, (2) homicide by cutting the throat and (3) intravenous heroin overdose. Merely retrospectively it could be cleared up that the deceased were homosexual but did not manifestly suffer from AIDS. The morphological findings in the lymph nodes and the postmortem serological findings are described in detail.

Acquired Immunodeficiency Syndrome↗
PubMed1987

AIDS: an overview of the pathology.

This article reviews the findings at postmortem examination on AIDS and separately details the surgical pathology of the gastrointestinal tract, liver, lymph nodes, and skin in these patients. Emphasis is placed upon the light microscopic features of the specimens commonly received in surgical pathology so as the promote the ready diagnosis of this important and grave disorder.

Acquired Immunodeficiency Syndrome↗
PubMed1987

[Clinical manifestations of rabies in the human. Case report and review].

Clinical symptoms and course in a 28 year old woman who suffered from rabies are reported. Neurophysiological and neuropathological findings in this patient, who died 21 days after developing initial symptoms, are presented in more detail. This disease appears to be rare in Central Europe. It can be treated effectively only by means of early detection and a special vaccination programme. Late recognition of lyssa specific symptoms in non-vaccinated patients is invariably associated with a fatal outcome. A review of current knowledge concerning rabies research is presented.

Adult↗
PubMed1986

HTLV-III/LAV viral antigens in lymph nodes of homosexual men with persistent generalized lymphadenopathy and AIDS.

The presence of core antigens of retrovirus HTLV-III/LAV, referred to as "AIDS-related virus" (AV), has been sought in lymph node samples of patients with persistent generalized lymphadenopathy (PGL, 28 patients), prodromal AIDS (1 patient) and AIDS with Kaposi sarcoma (3 patients). In 30 patients the deposition of viral antigens, detected by monoclonal antibodies to HTLV-III and LAV, could be observed within the germinal centers (GCs) primarily within the extracellular network of immune complexes, and the two patients who were negative were atypical. No AV could be found in normal tonsil or in samples with follicular hyperplasia of unknown etiology (20 cases). These findings, taken together with the ultrastructural identification of typical retrovirus particles in all 9 PGL and 2 AIDS cases studied, indicates that the network of follicular dendritic (FD) cells is an important reservoir of AV virus antigen at this site. The persistence of this retrovirus inside the GCs helps explain how the follicular hyperplasia affecting FD cells and B blasts in PGL may in progressive cases be accompanied by destruction of FD cells and gradual development of T4+ lymphopenia. T4+ T cells may circulate through the GCs and become infected with AV there. In addition, the identification of retrovirus antigen in situ may be of diagnostic value.

Acquired Immunodeficiency Syndrome↗
PubMed1985

[AIDS fatalities in Hamburg (status: February 1985)--legal medicine aspects].

The registration of patients with acquired immune deficiency syndrome (AIDS) and AIDS deaths is centralized for medical research. A short review of the epidemiological state of AIDS in Hamburg is given (situation as of February 1985), and the autopsy results of seven postmortem examinations are referred to. Kaposi's sarcoma was seen in four patients and opportunistic infections in all cases, especially as a result of Pneumocystis carinii and cytomegalovirus. Due to the constellation of groups with an increased risk of acquiring AIDS--homosexual males, intravenous drug abusers and prostitutes--forensic implications have to be expected.

Acquired Immunodeficiency Syndrome↗
PubMed1983

Immunopathologic aspects in human onchocercal lymphadenitis.

Lymph nodes (LN) from 50 patients with generalized onchocerciasis with or without diethylcarbamazine treatment and LN of patients with untreated localized onchocerciasis were studied. Light and electron microscopic examinations and immunostaining (PAP) were performed. In both forms of the disease the majority of microfilariae were degenerated and surrounded either by eosinophils or macrophages. In addition increased number of mast cells and plasma cells was observed. A direct contact between eosinophils and microfilariae, degranulation of eosinophils and free eosinophil granules in the electron dense material around the degenerating microfilariae were registered. The majority of plasma cells produced IgE or IgG. A positive staining for IgE was also present on the surface of mast cells. An extensive hyperplasia of the follicles was a characteristic feature in localized as well as treated generalized onchocerciasis. After anti-IgE staining a heavy intercellular deposition suggesting trapping of immune complexes by dendritic reticular cells developed in the light parts of the germinal centres. Not seldom, IgE producing blast cells were found in the follicles.

Diethylcarbamazine↗