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Biomedical subjects

P R Wilson

Publications and source records attributed to P R Wilson.

At least 19 recordsLinked to original sources
PubMed1992

Apolipoprotein A-I and apolipoprotein B containing lipoprotein particles in coronary patients treated with extracorporal low density lipoprotein precipitation (HELP).

Evidence for chemical and biological heterogeneity of human plasma lipoprotein density classes has been steadily accumulating over the last 15 years. Furthermore, several recent reports have indicated potential clinical significance of certain lipoprotein subspecies as either atherogenic or antiatherogenic. It is generally accepted that lipid lowering treatments can retard or even reverse development of atherosclerotic lesions. However, very little is known about effects of various lipid lowering treatments on specific lipoprotein particles. The purpose of this study was to explore the effects of heparin induced extracorporal low density lipoprotein precipitation (HELP) on various subspecies of plasma lipoprotein particles defined primarily by their apolipoprotein composition. Using particle specific enzyme immunoassays, the immediate changes in lipoprotein particle profiles were analyzed after a single HELP treatment in 12 patients with angiographically documented coronary artery disease. In a separate group of 6 patients, particles were repeatedly measured over a period of 96 h following a HELP treatment. Single HELP treatment caused an immediate and highly significant decrease (67%) in the concentration of simple lipoprotein particles containing apolipoprotein B (apo B) as a sole apolipoprotein (LP-B). Various subspecies of complex particles containing apo B and other apolipoproteins (Lp-B-complex) were also decreased although to a lesser degree (44-53%). HELP treatment caused an insignificant, 3% decrease of lipoprotein particles containing apo A-I but no apo A-II (Lp-A-I) and a 6% decrease in the concentration of particles containing both apo A-I and apo A-II (Lp-A-I:A-II). During the 96-h period following HELP treatment various apo B containing particles recovered at different rates in different patients.(ABSTRACT TRUNCATED AT 400 WORDS)

Apolipoprotein A-I↗
PubMed1992

Crown behaviour during cementation.

Complete seating of restorations during cementation is hindered by the need for excess cement to be expressed. It has been shown that postcementation seating is usually worse than precementation seating. Techniques have been developed to minimize this problem, including venting, die spacing and limiting cement placement, and these techniques are reviewed. The behaviour of the crown during cementation is considered, and consequences of crown cementation are discussed.

Cementation↗
PubMed1992

Effects of subcutaneous melatonin implants during long daylength on voluntary feed intake, rumen capacity and heart rate of red deer (Cervus elaphus) fed on a forage diet.

Subcutaneous melatonin implants were administered to castrated hand-reared male red deer (Cervus elaphus) during a 63 d period in spring, after which effects on voluntary feed intake (VFI), rumen pool size, rumen capacity (i.e. volume) and heart rate were measured on four occasions, evenly spread over a 12-month period, with the deer individually fed indoors on a diet of lucerne (Medicago sativa) chaff. Blood samples for hormone determinations were taken at intervals throughout the study. Day-time plasma melatonin concentration was approximately 5 pg/ml in control animals, whereas during melatonin administration it increased to 60-150 pg/ml and declined to 30 pg/ml by 142 d after the last implantation. Melatonin administration markedly depressed plasma prolactin concentration during the period of implantation, but thereafter plasma prolactin concentration rose in the treated animals during autumn and winter, whilst it declined in control animals over this period. VFI, rumen pool size and heart rate in control animals attained highest values in summer and lowest values in winter, showing a pronounced seasonal cycle. Melatonin administration depressed all these values in late spring and summer and increased all the values in autumn and winter, relative to control animals, and appeared to move the cycles by approximately 6 months. Melatonin-treated animals showed maximum values for all these measurements during winter. The castrated male deer showed little seasonal change in live weight, which was not affected by melatonin administration. The findings support the view that melatonin probably mediates the effect of daylength on digestive function in red deer. Rumen capacity remained relatively constant throughout the year, but rumen pool size as a proportion of rumen capacity increased with increasing VFI.

Animal Feed↗
PubMed1992

Interscalene blocks for chronic upper extremity pain.

A study of 25 patients was carried out to determine the efficacy of interscalene block (ISB) for the treatment of chronic upper extremity pain. An RSD score was used to categorize these patients. Seventeen of the 25 patients had less pain after ISB, and 14 also had increased range of motion of the affected limb. Patients with reflex sympathetic dystrophy (RSD)/causalgia, as well as other chronic pain conditions, improved. ISB was compared with stellate ganglion block (SGB) in patients undergoing both treatments. ISB seemed to be at least as effective as SGB for treatment of RSD/causalgia and may have some advantages over SGB. The role of somatic and sympathetic blockade is discussed.

Adult↗
PubMed1992

Tunnel restorations: a review.

Conventional cavity designs are coming under increased scrutiny because of an increased emphasis on preservation of tooth substance. The tunnel restoration when used with glass ionomer, may overcome some of the disadvantages of conventional cavity preparations. Justification for the use of the tunnel restoration is from a limited number of short-term clinical observations and destructive laboratory testing of marginal ridge strength. The technique is not without shortcomings. Long-term clinical and nondestructive laboratory trials examining the strength of teeth with tunnel restorations should be undertaken prior to its acceptance as a replacement for techniques in which the marginal ridge is removed.

Cermet Cements↗
PubMed1992

To vent or not to vent?

The complete seating of full coronal restorations during cementation is hindered by the inability of cement to flow from the internal surface of the crown, and possible binding of the crown on the tooth. Perforation venting is an effective technique to allow full seating but requires repair of the perforation. Provision of space between the crown and the tooth for cement flow is also an effective technique, and does not require repair of a perforation. Such spacing is commonly achieved with die spacer, and has the added possibility of decreasing crown deformation during cementation by diminishing binding between the crown and the tooth. A disclosing agent is effective in aiding complete seating by identifying areas of binding. These areas can subsequently be adjusted, which will allow more complete seating. The placement of an appropriate amount of cement in the crown or on the preparation is an important addition to cementation technique.

Cementation↗
PubMed1992

RSD score: criteria for the diagnosis of reflex sympathetic dystrophy and causalgia.

No standardized criteria for the diagnosis of reflex sympathetic dystrophy (RSD) are in common use. An RSD score scoring system of diagnostic criteria is proposed. Diagnosis of reflex sympathetic dystrophy by RSD score correlated well with clinical diagnosis in a group of 25 patients who had treatment for chronic upper extremity pain. Standardization of diagnostic criteria with the RSD score should enhance comparison of the outcomes of studies concerning the treatment of RSD.

Causalgia↗
PubMed1991

Ultrasonography of the reproductive tract and early pregnancy in red deer.

Thirty-five farmed red deer hinds two years of age or older were observed during mating in April and May and the dates of oestrus and, or, matings were recorded. From immediately before the breeding season and at approximately weekly intervals from the start of mating until all deer were 42 days pregnant, rectal ultrasonographic scans were taken using a 5 MHz linear transducer while deer were held standing in a restraining device. Scans were recorded on video. The vagina and cervix were visible with the lumen appearing as a continuous or intermittent white line, respectively. The non-pregnant uterus was observed in most cases and was immediately anterior to the bladder. Structures resembling ovaries were seen only occasionally. By seven days gestation a 5 mm vesicle could be observed in a few deer, and by day 14, oedema of uterine horns was apparent in some cases. A comma-shaped fetal mass 6 mm long, fetal membranes and placentomes could be observed on day 24. The heart beat was observed on day 28 when the fetus was 10 mm long. Limb buds were observed on day 31 and by day 37 the head with nose and eyes was distinguishable. Fetal movements were first observed on day 42. The accuracy of pregnancy detection before day 20 was 35 per cent, between 21 and 30 days gestation 71 per cent and from 31 to 42 days 98 per cent.

Animals↗
PubMed1991

Chronic neck pain and cervicogenic headache.

Acute and chronic neck pain and headaches are a major medical, industrial, and financial problem. In many cases, the pathophysiology is unknown, and the disability is often greatly in excess of the apparent tissue pathology and physiological impairment. Diagnosis and management of neck pain and cervicogenic headache calls for a rational and comprehensive approach. Many cases will have no identifiable pathology, and the pain and disability will continue despite the best efforts of all concerned.

Cervical Vertebrae↗
PubMed1991

Biologic aggressiveness of palpable and nonpalpable prostate cancer: assessment with endosonography.

The biologic aggressiveness of palpable versus nonpalpable prostate cancer was evaluated in 666 patients studied with endosonography over a 24-month period. Biologic aggressiveness was defined by a combined histologic and grade-stage category score. In 314 patients suspected of having prostate cancer 328 biopsies were performed. Carcinoma was detected in 99 patients, by means of both palpation and endosonography (n = 80), endosonography alone (n = 9), and palpation alone (n = 8); two cancers were not detected with either palpation or endosonography. All patients with normal results of digital examination had a combined grade-stage category score lower than 9. Fifty-five of 69 patients (80%) with abnormal results of digital examination and available histologic data had a histologic score of 6 or higher; 38 of these patients (69%) had a combined grade-stage category score of 9 or higher. Although the number of patients is small, these data suggest that nonpalpable cancers are biologically less aggressive than palpable ones and that the advantage of endosonography over palpation in detection of clinically significant cancers is limited.

Adenocarcinoma↗
PubMed1991

Taxonomy again?

Explore the source record for details and available documents.

Classification↗
PubMed1991

Eating strategies used by persons with head and neck cancer during and after radiotherapy.

This descriptive study identified the patient's perspective on eating problems during and after radiotherapy for head and neck cancer and pinpointed strategies used by patients to improve food intake during treatment. Eleven subjects were interviewed during a follow-up clinic appointment within 6 months of completion of radiotherapy and were asked to describe treatment problems and eating strategies. Open-ended interviews were tape-recorded and analyzed for recurring themes. A review of the medical records of each subject distinguished parameters of nutritional status during treatment. Eating strategies were clustered into three categories: food choice and preparation, attitude adoption, and acceptance of assistance. Subjects responded to treatment problems with specific eating strategies, implying relationships among treatment side effects, symptom management, and eating strategies.

Adaptation, Psychological↗