Biomedical subjects
P R Reich
Publications and source records attributed to P R Reich.
Practice or medical management: which key to success?
In the past, practice management systems were considered most important. Since revenues were based on fees for services rendered, the more patients and particularly procedures that could be scheduled in a day, the greater one's income. However, medical management systems are essential for the financial success of HMOs; these functions must also be present for the capitated group practice to be successful.
Complaining counts.
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Considerations in pharmaceutical conversion: focus on antihistamines.
The practice of pharmaceutical conversion, which encompasses three types of drug interchange (generic, brand, and therapeutic substitution), is increasing in managed care settings. Pharmaceutical conversion has numerous implications for managed care organizations, their healthcare providers, and their customers. Although drug cost may be a driving consideration in pharmaceutical conversion, a number of other considerations are of equal or greater importance in the decision-making process may affect the overall cost of patient care. Among these considerations are clinical, psychosocial, and safety issues; patient adherence; patient satisfaction; and legal implications of pharmaceutical conversion. Patient-centered care must always remain central to decisions about pharmaceutical conversion. This article discusses the issues related to, and implications of, pharmaceutical conversion utilizing the antihistamines class of drugs as the case situation.
Antiemetic therapy in managed care oncology: roundtable discussion.
Few diagnoses are feared more by patients than cancer. In addition to the life-threatening nature of many cancers, the spectre of very difficult the treatment provides patients with little or no level of comfort. However, recent advances in the treatment of the side effects of cancer chemotherapy are helping to change these attitudes. On April 4, 1996, a panel of experts was convened to discuss these issues and how they affect MCOs.
A computer program for the diagnosis of hematologic disorders.
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Programmed instruction in hematology using a new audiovisual system.
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Studies on the mechanism of enhancement of adenovirus 7 infection in African green monkey cells by simian virus 40: formation of adenovirus-specific RNA.
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Genetic differentiation by nucleic acid homology. 3. Relationships among mycoplasma, L-forms, and bacteria.
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Genetic relationships among serologically distinct mycoplasma.
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RNA of low molecular weight in KB cells infected with adenovirus type 2.
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Nucleic acid homology studies of adenovirus type 7-SV40 interactions.
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Nucleic acid homology studies of SV 40 virus-transformed and normal hamster cells.
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Biophysical evidence for linkage of adenovirus and SV40 DNA's in adenovirus 7-SV40 hybrid particles.
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Genetic relatedness among mycoplasmas as determined by nucleic acid homology.
Reich, Paul R. (National Institutes of Health, Bethesda, Md.), Norman L. Somerson, James A. Rose, and Sherman M. Weissman. Genetic relatedness among mycoplasmas as determined by nucleic acid homology. J. Bacteriol. 91:153-160. 1966.-A sensitive membrane filter method to detect nucleic acid homology was used to determine genetic relatedness among mycoplasma isolates. Deoxyribonucleic acid (DNA) was isolated from mycoplasmas and used as a primer for synthesis of tritium-labeled, complementary ribonucleic acid (RNA) by the enzyme RNA polymerase. DNA from each mycoplasma isolate tested was reacted separately with complementary RNA synthesized with homologous or heterologous DNA as primer. The quantity of DNA-RNA hybrids formed was assayed by the nitrocellulose membrane filter method. The amount of radioactivity bound to the membrane filter was used to measure the degree of homology between the nucleic acids. The three mycoplasma isolates from human oral cavities (DC 63, V2785, Botteicher) and the prototype strain PG21 placed in the Mycoplasma hominis type 1 group by gel diffusion and complement-fixation testing were investigated with this technique. Analysis of the data confirmed their immunological grouping with the M. hominis type 1 and their distinction from other human mycoplasmas. In contrast to the data from immunological studies, none of the four isolates tested appeared to be identical to any other. Preliminary experiments with DNA from four other mycoplasma isolates from tissue cultures inoculated with human material revealed them to be closely related, and possibly identical. The advantages of this nucleic acid homology technique for the study of relatedness among mycoplasmas are described.
Genetic differentiation by nucleic acid homology. IV. Relationships among Lancefield groups and serotypes of streptococci.
Weissman, Sherman M. (National Cancer Institute, Bethesda, Md.), Paul R. Reich, Norman L. Somerson, and Roger M. Cole. Genetic differentiation by nucleic acid homology. IV. Relationships among Lancefield groups and serotypes of streptococci. J. Bacteriol. 92:1372-1377. 1966.-A deoxyribonucleic acid-ribonucleic acid homology technique was used to measure the genetic relatedness among Lancefield groups and serotypes of streptococci. Organisms in different Lancefield groups were related, but were differentiated from each other. Serotypes within group A could be distinguished. Two isolates serologically classified in group A type 1 were indistinguishable. Streptococcus faecalis was only remotely related to streptococci of Lancefield groups A and H, whereas Diplococcus pneumoniae was more closely related to these organisms. The serological data were in good agreement with the results obtained with the homology method.
RNA production in adenovirus-infected KB cells.
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