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Biomedical subjects

P R Hull

Publications and source records attributed to P R Hull.

11 recordsLinked to original sources
PubMed1992

Treatment of cutaneous sporotrichosis with terbinafine.

Terbinafine, an allylamine antifungal agent, has been shown to have excellent in-vitro activity against dermatophytes. Several other fungi of importance also show in-vitro sensitivity. Because terbinafine is fungicidal rather than fungistatic in action, its efficacy in treating such fungal infections requires evaluation. Five patients with cutaneous sporotrichosis were treated with 250 mg of terbinafine twice daily. All of the patients were cured. Overall, the clinical response was rapid. In three patients, negative culture was achieved within 8 weeks; in the other two, negative culture was obtained at 12 and 32 weeks, respectively. Terbinafine was well tolerated, although one patient developed erectile dysfunction while receiving treatment. This was completely resolved on stopping the treatment. The treatment of sporotrichosis is also reviewed in this article.

Adult↗
PubMed1983

Cutaneous flavobacteriosis--polymorphous skin granulomas from Flavobacterium capsulatum. A case report.

A case of multiple eruptive skin granulomas caused by Flavobacterium capsulatum is described. The organism was resistant or poorly sensitive to all antibiotics except carbenicillin. Cure was brought about by using maximal doses of this drug. The source of the infection could not be proved, but it dated from an orthopaedic procedure to the elbow which was followed by a chronic cellulitis at the operation site. Since this is an organism known to occur in stored water, it was presumed that the flavobacterium was introduced into the wound from bottles of boiled and cooled water used in the operating theatre.

Bacterial Infections↗
PubMed1979

Actinic chickenpox. Light-distributed varicella eruption.

When areas of the skin which are normally covered become sunburnt just before chickenpox eruption, there occurs a marked intensification of the rash on the freshly burnt parts. This phenomenon is not widely known. Its history, published reports and our original observations on this 'actinic' chickenpox are presented, with comment on its pathogenesis.

Adult↗
PubMed1979

Systemic histoplasmosis with oesophageal obstruction due to Histoplasma granulomas. Successful treatment with rifampicin and amphotericin B.

A patient with oesophageal stenosis caused by Histoplasma granulomas is reported. He was treated with an initial combined course of intravenous amphotericin B and oral rifampicin. Complications included adrenal insufficiency, operative perforation of the oesophagus, amphotericin nephrotoxicity and tuberculosis. The histoplasmosis has not recurred for over 3 years.

Aged↗
PubMed1977

Keratolytic winter erythema or 'oudtshoorn skin': a newly recognized inherited dermatosis prevalent in South Africa.

A hitherto undescribed inherited dermatosis, traceable to certain 19th-century inhabitants of Oudtshoorn, CP, has been transmitted as an autosomal dominant to a large number of their present-day descendants. The disease consists of intermittent and recurrent centrifugal peeling, with redness, of the palms and soles in particular. In more severe cases similar patches are found extending up the limbs to the buttocks and the trunk generally. The inconvenience is usually moderate, but it may be incapacitating. Some temporary relief, but so far nothing permanent, can be offered through treatment.

Adolescent↗
PubMed1977

Topical nitrofurazone, a potent sensitizer of the skin and mucosae.

Although freely available, topical nitrofurazone (Furacin) frequently causes severe contact dermatitis, necessitating hospitalization. Six patients with sensitivity reactions to topical nitrofurazone are described. Our experience suggests that the free availability of this drug may increase the incidence of reactions due to its use, and should be condemned.

Adult↗
PubMed1971

Berg-adder bite.

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Abducens Nerve↗