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Biomedical subjects

P R Dasgupta

Publications and source records attributed to P R Dasgupta.

At least 19 recordsLinked to original sources
PubMed1982

Rate of formation of hydrogen peroxide (H2O2) in IUD-fitted human endometrium--a preliminary report.

Endometrial biopsy samples of (i) women (20-40 yr) using no contraceptive methods and (ii) women (25-45 yr) fitted with intrauterine contraceptive devices (CuT/Lippes loop) were analysed for the rate of H2O2 formation. The mean value for a normal proliferative endometrium was 10.56 +/- 1.45 nmoles H2O2 per milligram protein per 2 min, whereas the rate observed for samples of the same phase of the IUCD-fitted group without any bleeding episodes was 14.76 +/- 1.28 and that for members of the same group but who experienced excessive menstrual blood loss (menorrhagia) was 17.26 +/- 2.00, which was significantly higher than that of the control group.

Adult↗
PubMed1981

Presence of inhibin in testes of the Indian water buffalo Bubalus bubalis.

Isolation, purification and characterization of inhibin from the testes of the Indian buffalo Bubalus bubalis is described. The biological activity of the final product, which produced a single band on disc gel electrophoresis, was affected by heat treatment, 6 m urea, pH alteration and pepsin digestion. Chemically, it appeared to be a glycoprotein. The protein and carbohydrate components together accounted for a total of 63% of the dry weight, whereas 37% of the constituents were unknown.

Animals↗
PubMed1980

Formation of hydrogen peroxide in normal and copper-treated rat endometrium.

An intrauterine copper device stimulated endogenous hydrogen peroxide formation in whole homogenates and in the mitochondrial and microsomal (but not the nuclear) fractions of rat endometrial tissues. Uric acid also accumulated in the endometrium of copper-treated rats, but not in those fitted with a nylon device or sham operated. It is suggested that the contraceptive effect of copper may be related to these events.

Animals↗
PubMed1980

Hydrogen peroxide formation in the rat uterus under hormone-induced conditions.

The production of hydrogen peroxide was quantitated in the uterus of cyclic, ovariectomized (treated with hormones) and pregnant (days 1-6 post coitum) rats. This phenomenon was found to be dependent on oestrogen. The uterine responsiveness to hydrogen peroxide was correlated with peroxidase-catalysed inactivation of oestrogens in this target organ.

Animals↗