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Biomedical subjects

P R Cohen

Publications and source records attributed to P R Cohen.

At least 19 recordsLinked to original sources
PubMed1992

Tinea corporis confined to irradiated skin. Radiation port dermatophytosis.

BACKGROUND: Radiation port dermatophytosis (RPD) is an uncommon condition in which patients receiving radiation therapy concurrently have tinea corporis that is confined primarily to the irradiated skin. METHODS: The case of a 33-year-old man is reported who was receiving cobalt-60 radiation therapy for a nasopharyngeal carcinoma. During therapy, a dermatophyte infection developed in the treated field. RESULTS: Including this patient, there have been only three cases of RPD reported in the world literature. The clinical characteristics of patients with RPD are reviewed. The diagnosis, management, and pathogenesis of this condition are discussed. CONCLUSIONS: Because the cutaneous manifestations of RPD may be misinterpreted clinically as acute radiation-induced dermatitis, this condition may be more prevalent than the paucity of published reports suggests.

Adult↗
PubMed1992

Muir-Torre syndrome in patients with hematologic malignancies.

The Muir-Torre syndrome (MTS) is defined as the concurrent or sequential discovery of at least one sebaceous gland tumor and a minimum of one internal malignancy. A man with Hodgkin's lymphoma who subsequently developed an ocular sebaceous carcinoma in situ is described and the world literature of patients with the MTS and hematologic malignancies is reviewed.

Adenocarcinoma↗
PubMed1992

The concurrent presence of systemic disease pathogens and cutaneous Kaposi's sarcoma in the same lesion: Histoplasma capsulatum and Kaposi's sarcoma coexisting in a single skin lesion in a patient with AIDS.

the concurrent presence of infectious organisms within cutaneous lesions of Kaposi's sarcoma (KS) in persons with the acquired immunodeficiency syndrome (AIDS) has been demonstrated. We report the first patient with AIDS in whom both KS and Histoplasma capsulatum were documented within the same cutaneous lesion. Pathogenic organisms of other fungal, mycobacterial, and viral diseases in KS lesions in other patients seropositive for human immunodeficiency virus are reviewed. Possible explanations for the coexistence of a focus of infection within a lesion of KS are discussed. It may be that in some patients the infection acts as a stimulus to induce vascular proliferation and subsequent development of sarcoma. There is also support for the idea of organism seeding in vascular tissues in the course of dissemination of infection. It is important to rule out the presence of coexistent infections or more than one pathologic process in skin lesions in patients with AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1992

Red lunulae: case report and literature review.

Thumb nails with asymptomatic red lunulae were noted in a 54-year-old woman with testosterone propionate-responsive vulvar lichen sclerosus et atrophicus of 4 years' duration and localized vitiligo that had been treated with topical corticosteroids for 15 months. Cutaneous and systemic disorders in which red lunulae have been observed are reviewed.

Female↗
PubMed1992

Geriatric nail disorders: diagnosis and treatment.

Age-associated nail changes and disorders are common in elderly patients. Characteristic changes in color, contour, growth, surface, thickness, and histology occur in the nail unit as persons become older. Several onychodystrophies are frequently observed in these elderly patients: brittle nails, those induced by faulty biomechanics and trauma, infections, onychauxis, onychoclavus, onychogryphosis, onychophosis, splinter hemorrhages and subungual hematomas, and subungual exostosis. Awareness of the signs and symptoms of the aging nail will enable better assessment and management of the onychologic concerns of this group of older patients.

Aged↗
PubMed1992

Cancer recurrence following Mohs micrographic surgery: a mechanism of tumor persistence.

Recurrence of basal cell carcinomas after Mohs micrographic surgery is rare but known to occur. This report describes the recurrence of a basal cell carcinoma of the forehead after Mohs surgery in order to illustrate a previously undescribed mechanism of tumor persistence and recurrence despite thorough microscopic evaluation of all surgical margins. The value of the surgeon's reviewing all prior histologic sections before performing micrographic surgery, the importance of resecting all scar tissue from a previous surgical site prior to determination of tumor-free margins, and the potential usefulness of a three-tiered closure after excision of a cutaneous malignancy that involves the muscular layer are discussed.

Aged↗
PubMed1992

Zosteriform and epidermotropic metastasis. Report of two cases.

We report two cases of zosteriform metastasis to the skin. One patient had epidermotropic papulovesicular metastases from a presumed cutaneous adnexal neoplasm. The second patient had painful zoster-like papulovesicles from metastatic breast cancer. Previously reported dermatomal or zosteriform metastases are reviewed.

Adenocarcinoma↗
PubMed1992

Imported fire ant stings: clinical manifestations and treatment.

Stings by imported fire ants result in local reactions to the insect's venom; less frequently, they induce systemic allergic reactions. A 19-month-old child developed a characteristic localized cutaneous reaction at the sites of numerous stings after disturbing an ant mound. He experienced no secondary complications, and his pustular lesions resolved with conservative treatment.

Animals↗
PubMed1992

Genodermatoses with malignant potential.

Disease-associated malignancy may occur in several inherited conditions with dermatologic manifestations. These genodermatoses include nevoid basal cell carcinoma syndrome, Cowden's disease, multiple endocrine neoplasia syndromes, neurofibromatosis and Peutz-Jeghers syndrome. Although most of these genodermatoses are rare, recognition of their cutaneous features can facilitate early diagnosis of the systemic condition and surveillance for neoplasm. Appropriate evaluation of the patient's family, as well as genetic counseling, should be performed when the diagnosis of a genodermatosis with malignant potential is established.

Diagnosis, Differential↗
PubMed1992

Athlete's nodules: sports-related connective tissue nevi of the collagen type (collagenomas).

Sports-related connective tissue nevi of the collagen type (collagenomas) have been referred to as athlete's nodules. Surfers, boxers, marbles players, and football players are some of the athletes in whom these lesions have been observed. The nodules can be found on the dorsal aspect of the feet, knees, or knuckles and can readily be differentiated from other conditions by either clinical history or microscopic features or both. Treatment options include conservative measures or surgical intervention. Recurrent trauma and friction to the involved location are likely causative factors. Although the ultrastructural pathogenesis remains to be established, changes in the molecular metabolism of collagen resulting in enhanced synthesis and/or accumulation of collagen may have a contributory role.

Athletic Injuries↗
PubMed1992

Concurrent Sweet's syndrome and erythema nodosum: a report, world literature review and mechanism of pathogenesis.

Sweet's syndrome (acute febrile neutrophilic dermatosis) and erythema nodosum are reactive dermatoses whose pathogenesis is currently undefined. Although there are several associated conditions that both of these disorders have in common, the appearance of Sweet's syndrome and erythema nodosum in the same person is rare. Only 8 individuals with biopsy confirmed lesions of both dermatoses were described in the world literature. We describe a 30-year-old woman with biopsy confirmed lesions of Sweet's syndrome on her hand and erythema nodosum on her legs. She had been taking an oral contraceptive and an appetite suppressant during the 5 months before these dermatoses appeared. Both cutaneous lesions rapidly responded to topical corticosteroid ointment and have not recurred since her medications were discontinued. The association of Sweet's syndrome and erythema nodosum is reviewed, their similarities discussed, and a pathogenesis is proposed.

Adult↗