Prospects of gene therapy for ocular diseases.
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Biomedical subjects
Publications and source records attributed to P R Chatterjee.
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Cataract is the major cause of blindness worldwide. The transition of couching of cataract to most modem phaco-emulsification gained popularity with more scientific capsulorhexis. Ongoing research is taking place with laser technologies for removal of cataract. Surgery has an important role in advanced corneal diseases. Corneal transplantation is the most successful form. The refractive errors can be corrected by laser-assisted in-situ keratomileusis, intrastromal corneal rings and phacic intra-ocular lenses. Current research is going on to identify the gene responsible for glaucoma and once this is identified, medical therapy can be developed to control the disease. Thermocautery or photocoagulation and indenting the globe so as to bring the choroid nearer the break by scleral buckling forms the basis of modern surgery of retinal detachment. Vitreoretinal diseases, macular degeneration, diabetic retinopathy are no longer considered problematic. We are optimistic that more clinical breakthroughs are expected in the 21st century with new advances of ophthalmic researches.
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A total of 800 cases of ocular injuries were studied during the period from January, 1982 to December, 1985 at the department of eye, North Bengal Medical College and Hospital, Darjeeling. Major ocular injuries (n = 248) required hospitalisation. The rest 552 cases had minor injuries and treated at outpatients' department. The incidence of age, sex, mode of injury, interval between injury and first observation, structural damage were studied in all these cases.
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Forty cases of ophthalmic lesions were subjected to fine needle aspiration cytology for pre-operative diagnosis which included retinoblastomas (5 cases), inflammatory and neoplastic lesions of the eyelid and lacrimal glands (29 cases) and extra-ocular orbital lesions (6 cases) inclusive of 3 cases of rhabdomyosarcomas. The lesions were distributed in both the eyes almost in equal proportions. Histological confirmation was obtained in 85% of cases; false positive in only one case with malignant neoplasm of the eyelid and false negative also in only one case with inflammatory pseudotumour which were, histologically, proved to be adenoma of tarsal gland and lymphocytic lymphoma respectively.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
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