The globus sensation is one of the most frequent complaints in a basic ENT clinic. The etiology is still unknown, although some hypotheses have been suggested such as: psychological abnormalities, esophageal and cricopharyngeal muscle disfunction and the laryngopharyngeal reflux. Laryngopharyngeal reflux is the most frequent pathology related to the globus feeling. We've tried in this study to determine the incidence of laryngopharyngeal reflux in a group of 30 patients with globus feeling. We found 26.7% of these patients with an abnormal pH monitoring test.

Adult↗

PubMedDate not supplied

Supravital study of guinea pig cochlea referring especially to kanamycin labyrinthotoxy.

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Animals↗

PubMedDate not supplied

[Neurocysticercosis. An emergent disease].

Neurocysticerosis is an affection of the central nervous system by the larvae of the Taenia solium. Although its diagnosis in our country is exceptional, in recent years a notable increase in the number of cases diagnosed has been observed, due to the phenomenon of immigration from countries where the disease is endemic. The most frequent form of presentation of neurocysticercosis is seizures, followed by headache. To diagnose it we must evaluate the epidemiological data, the clinical record and confirm this through neuroimage and immunological studies. The treatment selected should be pharmacological, principally with albendazole, and surgery reserved for cases where the former fails. Hygienic measures and the treatment of patients with teniasis are of great importance. Neurocysticerosis has ceased to be an exceptional diagnosis and given the foreseeable increase of its incidence in our milieu, health professionals must understand this disease and include it at higher levels of the algorithms of differential diagnosis.

Diagnosis, Differential↗

PubMedDate not supplied

Poly(ADP-ribose)synthetase from HeLa cell nuclei: purification and properties.

Poly(ADP-ribose)synthetase has been purified over 600-fold from HeLa cell nuclei. Upon electrophoresis on 9% polyacrylamide slab-gel in the presence of SDS, the purified enzyme resolved in two bands that showed similar apparent Mr values, 110,000 and 118,000. The aminoacid composition of the two components differed from compositions reported for the same enzyme from other sources. In accordance with other reports, the enzyme purified from HeLa cell nuclei exhibited an absolute dependence on DNA and its activity was modulated by changes in the histone concentration. Incubation of intact nuclei from HeLa cells with [14C]NAD resulted in the isolation of a poly(ADP-ribose)synthetase to which a definite radioactivity is bound. These results are taken as a further demonstration that the enzyme can be auto-ADP-ribosylated.

Adenosine Diphosphate Ribose↗

PubMedDate not supplied

[Bell's facial paralysis. Study with magnetic resonance and gadolinium].

The facial never was investigated by gadolinium-enhanced MR in 7 patients diagnosed as Bell's Palsy. All cases showed complete facial paralysis, and were studied on the acute phase of the disease. Most Bell's palsy patients demonstrate facial nerve enhancement, usually in the tympanic and labyrinthine segments. No gadolinium enhancement on the opposite facial never was seen in this serie. Because Gad-MR does not appear to influence the therapeutic decision, it may not be necessary in the management of Bell's Palsy.

Adult↗

PubMedDate not supplied

[Comparative study of 2 antibiotic prophylactic protocols in oncologic surgery of the pharynx and larynx].

The use of antibiotic prophylaxis in oncological pharyngeal and laryngeal surgery has reduced the risk of postoperative wound infection, which decreases morbidity and health-care costs. We report the results of a prospective randomized study in our hospital comparing the effectiveness of two antibiotic protocols, amoxicillin-clavulanate and clindamycin plus gentamicin, both given for 24 hours, in patients who underwent clean-contaminated oncological surgery of the pharynx or larynx.

Amoxicillin↗

PubMedDate not supplied

[Early endoscopic findings of the upper respiratory and digestive tract in patients undergoing translaryngeal intubation for more than 24 hours].

The large number of patients undergoing translaryngeal intubation justifies acquiring full knowledge of the complications that this invasive procedure may produce. The short-term problems that cause immediate complications (esophageal intubation, cuff rupture) are severe and do not escape notice. However, less immediate problems often pass undetected, although their presence may worsen the patient's outcome. Endoscopy allows the condition of the upper respiratory and digestive tract to be examined in order to detect and correct such problems. In this preliminary study, risk factors are analyzed and the lesions are described, classified, and quantified. Forty-seven adult patients were studied prospectively. In the first 24 to 48 hours of intubation, rigid endoscopy was performed under sedation using 0 degree and 30 degrees rigid endoscopes. The high rate of glottic edema (63.8%) was noteworthy because knowledge of this condition can be vital for preventing extubation failure.

Adolescent↗