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Biomedical subjects

P Puiatti

Publications and source records attributed to P Puiatti.

28 records · Page 2Linked to original sources
PubMed1986

Ketoconazole treatment in superficial mycoses.

Ketoconazole is a new antifungal drug, used for oral treatment, with a broad spectrum of activity. It is a member of the imidazole series and is active in superficial and deep mycotic diseases, in candidosis and pityriasis versicolor. This new imidazole derivative has been successfully administered in several cases of dermatophytosis, yeasts and pityriasis versicolor in the authors' clinic, as well as in many other research centres. Treatment has been given to patients with tinea corporis, tinea cruris, tinea pedis, with or without location in interdigital spaces, while the cases of tinea capitis are still under investigation. The following variants of candida infections have been treated: onychomycosis, intertrigo and mucocutaneous candidosis due to prolonged immunosuppressive therapy. No remarkable haematochemical disorders have been observed after treatment.

Adolescent↗
PubMed1983

T-cell subsets in melanoma patients evaluated by anti-T-cell monoclonal antibodies.

Functional T-cell subpopulations have been evaluated in the peripheral blood of 124 melanoma patients (71 non-metastatic and 53 metastatic) using monoclonal antibodies: OKT3, OKT4, OKT8, every 2 months for 1 year. The levels of OKT3+ cells were significantly lower in metastatic patients than in normal controls and they decreased in the advanced phases of the disease. Percentages and absolute OKT4+ cell values were reduced in metastatic patients only, while a significant reduction in OKT8+ cells was noted in both long-surviving, non-metastatic and metastatic patients. The ratio of OKT4+/OKT8+ cells was increased in non-metastatic patients and in patients remaining metastasis-free for 4 years after resection of their metastases. Patients with prolonged survival show normal T-helper cells and low T-suppressor cells with a significant increased ratio OKT4/OKT8. In the patients who developed visceral metastases and in those who died the progressive reduction in total T cells is mainly due to the decrease in OKT4+ cells.

Adult↗
PubMedDate not supplied

[Chronic HCV hepatopathy and cryoglobulinemia. The associated clinical spectrum].

BACKGROUND AND AIM: The hepatitis C infection (HCV) has numerous extrahepatic manifestations owing to the systemic nature of the infection itself. HCV infects the cells that carry a CD 81 receptor and show a marked tropism for hepatocytes, bone marrow staminal cells and circulating lymphomonocytes. One consequence of this tropism is the activation of B lymphocyte clones with the consequent production of autoantibodies and cryoglobulins. The secondary event is the formation of circulating immune complexes which, having precipitated at an intravascular level, may cause part of the extrahepatic manifestations associated with these infections. METHODS: This retrospective study evaluated the manifestations correlated and/or associated with HCV hepatitis and mixed cryoglobulinaemia. RESULTS: This analysis showed that 75% of consecutively studied patients reveal clinically important extrahepatic manifestations. CONCLUSIONS: This underlines the "broad spectrum" action played by the hepatitis C virus in the host organism.

Adult↗