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Biomedical subjects

P Puech

Publications and source records attributed to P Puech.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Distribution pattern of alpha and beta myosin in normal and diseased human ventricular myocardium.

All fibers in three normal, four dilated, and two ischemic human ventricles were classified according to their myosin content using three sets of monoclonal antibodies each specific for one myosin heavy chain isoform (alpha, beta and beta'). Numerous fibers contained only beta myosin heavy chain (denoted as beta fibers), others contained either alpha and beta, or beta and beta' myosin heavy chain (denoted as alpha beta and beta beta' fibers, respectively). The percentages of alpha beta fibers were systematically determined along the walls of seven homologous regions of the ventricular myocardium. In all ventricles, there was an alpha beta-fiber transmural gradient, with less alpha beta fiber in the subendocardium than in the subepicardium. More alpha beta fibers were found in the right than in the left ventricular wall but there was no difference between the mid-portion and the apex of the free wall of each ventricle. The diseased ventricles contained a lower alpha beta fiber percentage than the normal hearts. beta beta' fibers were very rare in the normal ventricles (less than 5%) and almost inexistent in pathological hearts. The correlation between the mean alpha beta fiber percentages of the diseased hearts and their cardiac indices (r = 0.88, P less than 0.05) suggests that the small amount of alpha myosin distributed in a large number of ventricular fibers could play a role in the contractile performance of the heart. In conclusion, this study provides evidence for 1) an alpha beta fiber transmural gradient, and 2) a lower alpha myosin ratio in diseased than in normal human ventricle.

Antibodies, Monoclonal↗
PubMedDate not supplied

[Pathophysiology of auricular flutter and fibrillation in patients with Wolff-Parkinson-White syndrome. A case successfully treated by fulguration of the bundle of His].

Atrial flutter and fibrillation are common in patients with Wolff-Parkinson-White syndrome. Pathophysiology of these arrhythmias is poorly understood. Treatment is empirical and oriented to symptomatology. Here we describe a patient with Wolff-Parkinson-White syndrome with paroxysmal reentrant orthodromic AV tachycardias and atrial flutter episodes that disappeared after His Bundle fulguration. This suggests that a complete AV reentry circuit favored the occurrence of atrial flutter in this patient.

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