Biomedical subjects
P Ponsot
Publications and source records attributed to P Ponsot.
[Occurrence and nature of hyperamylasemia in chronic alcoholics].
The purpose of this work was: a) the prospective study of the prevalence of hyperamylasemia in 100 patients with chronic alcoholism; b) the determination of the serum isoamylase distribution in patients with hyperamylasemia by an inhibitor assay; c) the search of the origin of elevated serum isoamylase S. Moderate hyperamylasemia was found in 15 patients. The importance of alcohol abuse, the prevalences of cirrhosis and smokers were not statistically different from those observed in normoamylasemic patients. After one week of hospitalization, serum amylase was still elevated in 11 of 14 alcoholic patients. Hyperamylasemia was due to an increase in the isoamylase P in 5 cases, in the isoamylase S in 7 cases, and in both forms in 3 cases. Activities of serum lipase and isoamylase P were roughly parallel. Only two out of 8 patients with elevated isoamylase P had chronic pancreatitis. The salivary origin of elevated isoamylase S was suspected in only one out of 10 patients. This work shows that the origin of moderate hyperamylasemia, observed in alcoholic patients, is often extrapancreatic. It is suggested that the dosage of serum lipase simpler than that of isoamylases, may be routinely used in chronic alcoholic patients for diagnostic purposes.
[Chronic pancreatitis].
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[Stenosis of the left hepatic duct with intrahepatic lithiasis: treatment by the percutaneous transhepatic approach].
The authors report the case of a 78-year-old woman suffering from cholangitis secondary to intrahepatic biliary stricture and intrahepatic lithiasis. Successful management consisted of successive percutaneous transhepatic internal-external biliary drainage, balloon dilatation of the stricture and gallstone mobilisation and removal through the stricture. No complications were noted.
[Gastric angiodysplasias and Rendu-Osler's disease].
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[A rapid method for continuous flow measurement of cholesterol contained in high density lipoproteins (HDL) (author's transl)].
The authors utilized a reagent containing concanavalin A, a vegetal lecithin, to selectively precipitate lipoproteins containing apoprotein B, a component of VLDL, LDL, and Lp (a) which are well known for their atherogenic risk. During this precipitation "true" high density lipoproteins remain in solution. HDL cholesterol determination which constitutes an indirect indication of HDL activity or concentrations is performed by an enzymatic method using an automated continuous flow technique carried out on an Auto Analyzer II (Technicon Corp.). This rapid, easy determination obtains results comparable to other methods, particularly those chosen by the Société Française de Biologie Clinique (French Society of Clinical Biology). This technique should permit all laboratories to confirm an atherogenic index.
[Malignant duodenal stenoses: can endoscopic or radiological insertion of metal stent replace surgical derivation?].
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[Pancreatic intraductal adenoma, adenomatosis and adenocarcinoma].
Three cases of adenomatous lesions of the pancreatic ducts are reported. There was 1 case each of adenoma of the main pancreatic duct, adenomas of the uncinate process and diffuse adenomatosis of the cephalic pancreatic ducts with ampullary involvement. On ultrasound and computerized tomography, the main pancreatic duct was enlarged in all cases, associated in 2 cases with a mass in the head of the pancreas, and in 1 case, with pseudocystic dilation of the uncinate process ducts. At duodenoscopy, the papilla was tumoral in 1 case, enlarged with mucous flow in 1 case and normal in the third case in which cytologic examination of secretions disclosed glandular cells. Endoluminal lesions were diagnosed by endoscopic retrograde pancreatography in 2 cases and on gross pathologic examination in 1 case. Treatment was surgical: cephalic pancreatoduodenectomy in 2 cases and local resection in 1 case, which relapsed 3 years later. At pathology, lesions were benign in all 3 cases including 1 case of severe dysplasia. On the basis of these 3 cases and a review of the literature, distinctive features of pancreatic endoluminal adenomas and adenocarcinomas are specified. Pancreatic resection is mandatory because of the risk of pancreatic obstruction and malignant degeneration.
[Hypoxemia and aging (author's transl)].
Hypoxemia during rest reveals the aging of the respiratory tract. The evolution curve of the PaO2 related to age is parallel to that of static elastic recoil pressure. This hypoxemia is moderate and without any serious functional consequences in a healthy subject. Abnormalities of the ventilation-perfusion ratio are the main causes. The increase of the anatomical dead space and the increase of the right-left shunt only play a moderate part. On the other hand the increase of closing volume seems the major factor. Thus the ventilation distribution becomes dependent on the amplitude of the tidal volume. The response of the aged subject to hypoxia is lessened for mechanical and neurological reasons explaining why a respiratory distress can appear rapidely and sometimes unexpectedly.
[Acute hepatitis caused by erythromycin propionate].
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[Endoscopic treatment of superficial digestive cancer].
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[Letter: Real value of the determination of gamma glutamyl transpeptidase activity in hepatobiliary pathology. Apropos of 5,000 determinations].
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[Interference of minovine (a Vinca minor alkaloid) on hospital emergency toxicologic tests for derivatives of 5H-dibenzo(b,f)azepine].
The authors report the possible interference due to minovine when seeking tricyclic antidepressant derivatives in biological material or pharmaceutical substances. However, their work has shown that kinetic studies using absorption spectrophotometry of the colouration obtained with phosphoric-ceric reagent and thin layer adsorbant chromatography make it possible to eliminate the doubt and identify the Vinca-Minor alkaloid.