Biomedical subjects

P Polterauer

Publications and source records attributed to P Polterauer.

At least 109 records · Page 6Linked to original sources

PubMed1986

[Autologous venous bypass in the therapy of arterial occlusive disease of the femoropopliteal area: long-term results].

The outcome of 532 femoro-popliteal vein grafts performed electively during the years 1970 to 1985 for obliterative arterial disease, was analyzed using the documentation-system of the Austrian Society for Vascular Surgery, as well as SAS and BMDP-software on an IBM 4381 computer of the Medical Faculty. The probability of function was estimated according to the Kaplan-Meier method, statistical differences were checked with Breslow's and Mantel's test, the proportional hazards regression model (Cox) was used to elucidate the influence of different risk factors on each own and in combination of each other. In the univariate analysis, the preoperative clinical status was found to be of prognostic significance, but technical details such as intraoperative as well as postoperative arteriography or site of the distal anastomosis were not important. A postoperative coumarine treatment had no demonstrable impact on graft function, but positively influenced the probability of patient survival. Taking into account the factors found to be of significance in the univariate analysis (e.g. set of factors: site of distal anastomosis, diabetic state and smoking habits) were analyzed using the proportional hazards regression model but were found of no major influence. The factors preoperative clinical status, patients age, and coumarine therapy significantly influenced the probability of patient survival, but diabetes mellitus and smoking were found to be not important.

Aged↗

PubMed1986

Influence of anticoagulant treatment in preventing graft occlusion following saphenous vein bypass for femoropopliteal occlusive disease.

Seventy-one patients underwent a classical reversed saphenous vein graft for femoropopliteal occlusive disease and were enrolled in a controlled clinical trial. During the second postoperative week the patients were allocated randomly into one of two groups; group 1 consisted of 34 patients who received coumarin, group 2 (37 patients) served as a control group without any anticoagulant treatment. The mean follow-up was 18 months. After 12 months the cumulative patency rate was 81 per cent and after 18 months 75 per cent; for patients receiving coumarin treatment, the respective figures were 90 and 82 per cent and for those with no anticoagulant treatment 72 and 67 per cent, the decrease being significant. When the bypass operation was performed for limb salvage (clinical stages III and IV) the overall results were worse (12 months, 72 per cent; 18 months, 68 per cent) than in stage II and stage II-III (12 months, 90 per cent; 18 months, 85 per cent). In limb salvage surgery the positive effects of anticoagulant treatment were significant (with treatment: 12 months, 87 per cent; 18 months, 87 per cent; without treatment: 12 months, 60 per cent; 18 months, 53 per cent). The site of the distal anastomosis (above knee: 12 months, 81 per cent; 18 months, 73 per cent versus below knee: 12 months, 80 per cent; 18 months, 75 per cent) did not have any demonstrable influence on the patency rate.

Aged↗

PubMed1986

Biological half-life of prostacyclin and 6-oxo-PGF1 alpha levels in plasma of patients with colonic cancer.

Prostaglandins have been shown to play a central role in the formation of cancer. The synthesis of prostacyclin and its bioavailability may be an important local determinant for metastasis. As the amount of the biologically active substance is dependent in part on the half-life (T/2) we examined the question as to whether the T/2 of prostaglandin I2 (PGI2) is altered in patients suffering from colonic cancer at various stages of the disease. In addition, the influence of various therapeutic regimens was investigated. In 58 patients with various stages of colonic cancer no significant difference in PGI2-T/2 could be detected. No significant difference could be found before (10, 11 +/- 1, 9 min) and after (10, 03 +/- 1, 8 min) tumor resection, before (9, 89 +/- 1, 5 min) and after 10, 35 +/- 1,8 min) chemotherapy, before (10, 36 +/- 1, 5 min) and after (10, 89 +/- 2, 31 min) irradiation as well as before (8, 86 +/- 1, 9 min) and after (9, 07 +/- 1, 2 min) tumor resection at least 4 to 6 years ago. In 14 healthy people PGI2-T/2 (10, 05 +/- 2, 1 min) did not differ significantly. In all the 58 patients the plasma levels of 6-oxo-PGF1 alpha, the stable derivative of PGI2 were measured. As compared to healthy controls (less than 1 pg/ml) the actual 6-oxo-PGF1 alpha values of patients with colonic cancer were significantly increased. However, no correlation to the T/2 of PGI2 (r between 0, 03 and 0, 21, n.s.) in plasma in vitro could be discovered. After curative tumor resection and after chemotherapy the plasma levels of 6-oxo-PGF1 alpha were significantly lower than before. The data suggest that in patients suffering from colonic cancer the speed of degradation of PGI2 is not a key determinant in local hemostatic dysregulation favouring early metastasis. However, PGI2 or its stable derivatives may be involved in the development of colonic cancer.

6-Ketoprostaglandin F1 alpha↗

PubMed1986

Degradation of prostacyclin in the plasma of patients with terminal liver insufficiency.

It has been suggested earlier that the increased bleeding tendency observed in patients with hepatic coma is due to prostaglandin I2. Various experimental studies have reported an increased prostaglandin I2-formation, an enhanced plasma factor activity and a prolonged synthesis in-vitro. However, the rate of degradation of prostaglandin I2 in plasma could be another determinant alterating the locally available biologically active substance but this has not been examined so far. Thus, we examined the half-life of synthetic prostaglandin I in-vitro in plasma from 25 patients with terminal liver insufficiency in different stages of hepatic coma. In 8 healthy volunteers a 6 months follow up showed no significant change. The half-life of prostaglandin I in controls was 10.21 +/- 2.70 minutes, no different from coma stage I (10.16 +/- 1.36 minutes), coma stage II (10.86 +/- 2.24 minutes), coma stage III (10.95 +/- 3.06 minutes) or coma stage IV (12.07 +/- 2.88 minutes). However, a modest trend towards a prolongation and an increase in standard deviation with the coma stage can be noted. No influence of various drugs commonly used in these patients could be seen. It can thus be concluded that there is no important difference in degradation speed of prostaglandin I2 in the plasma of patients with terminal liver insufficiency, which could account for the increased bleeding tendency.

Adult↗

PubMed1986

Irradiation-induced changes in the subclavian and axillary arteries after radiotherapy for carcinoma of the breast.

Three case reports are reviewed to illustrate the possibility of treating irradiation-induced lesions of the subclavian-brachial vascular segment (aneurysm and segmental occlusions) 14, 20, and 26 years after radical mastectomy and subsequent radiotherapy. All patients had an extraanatomic vein bypass graft from the carotid to the brachial artery crossing the shoulder near the acromioclavicular joint, with the advantage that the tissue changed by radiotherapy or infected by ulceration could be circumvented. There were no postoperative complications, with adequate function of the grafts (follow-up, 17, 24, and 20 months, respectively).

Aged↗

PubMed1985

Urokinase antigen in plasma of patients with liver cirrhosis and hepatoma.

Plasma urokinase antigen levels were studied in 78 patients suffering from liver diseases. Blood was drawn before any specific medication was initiated. Impairment of liver function was comparable in all patients. In both groups of cirrhotic liver disease (alcoholic and non-alcoholic), normal levels of plasma urokinase antigen were found as compared to age-matched control groups. In both groups of patients with hepatomas (with or without a history of liver cirrhosis), however, significantly increased plasma urokinase antigen levels could be determined. These data indicate that an increase in plasma urokinase antigen might rather relate to malignant growth in liver disease than to impaired liver function.

Adult↗

PubMed1985

[Serum concentrations of tissue polypeptide antigen and alpha 1-fetoprotein in patients with primary liver cancer, liver metastasis and liver cirrhosis].

Tissue Polypeptide Antigen (TPA) and alpha 1-fetoprotein (AFP) were determined in sera of 21 patients with hepatocellular carcinomas, in 20 patients with extrahepatic carcinomas and metastases of the liver, as well as in 26 patients with cirrhosis of the liver. TPA was increased (greater than 85 U/L) in all patients with malignant hepatomas, in 80% of patients with metastatic liver cancer and in 35% of patients with cirrhosis of the liver. The critical serum TPA level, above which only malignant liver tumours lay, was statistically evaluated and found to be 187 U/L. All patients with benign liver disease and half of the patients with metastatic liver disease showed TPA values lower than 187 U/L. All of the patients with hepatocellular carcinoma and half of the patients with metastatic liver cancer had TPA values greater than 187 U/L; all of our patients with cirrhosis of the liver, as well as half of the patients with metastatic liver cancer had lower TPA values. 86% out of all hepatoma patients showed increased AFP levels (greater than 9 ng/ml), whereby the AFP concentrations were in the range which is highly suggestive of hepatoma (greater than 174 ng/ml) in 67% of all patients with malignant hepatomas. Patients with metastatic liver cancer and cirrhosis of the liver had AFP levels lower than 174 ng/ml AFP. TPA is an unspecific tumour marker, which can be used together with AFP in the diagnosis of unclear defects in liver parenchyma, in supervision of cirrhosis, as well as in control assessment during chemotherapy or after tumour resection.

Antigens, Neoplasm↗

PubMed1985

[Sonographic studies of the aorta after prosthetic replacement (follow-up of 112 patients)].

Sonography should be routinely used for clinical follow up of patients with prosthetic grafts replacing the abdominal aorta and iliac vessels. 112 patients were investigated and the normal findings as well as pathological changes following aortic graft implantation are described and the difference between Dacron and PTFE-Y graft material discussed. Adequate visualization of anatomic detail of the graft was found in 82.1%. In the remaining patients the site of implantation was partly or completely overshadowed by bowel gas. 67.4% showed normal graft findings, whilst the remaining 32.6% exhibited incipient or manifest minor or major pathological changes such as dilatation of graft material, kinking, pseudoaneurysm, intraluminal thrombotic material and occlusion of parts of the implanted grafts. Dilatation was seen only with Dacron grafts and kinking only with PTFE-Y graft material. In combination with the clinical findings sonography helps to reduce the necessity of invasive angiographic procedures and allows early recognition of abnormal anatomical situations.

Aged↗

PubMed1984

[The PTFE plastic prosthesis as an arterial replacement: experiences over a 5-year period].

Unilateral iliac femoral reconstructions with PTFE are yielding good results-similar to those with Dacron, with patency rates of 75, 67, and 65% at 1, 2 and 3 years, respectively (Kaplan-Meier). PTFE has additional advantages compared with other materials: a) no need of preclotting; b) smooth inner surface-easy thrombectomy in case of thrombosis and c) good handling characteristics. In view of the above-mentioned facts PTFE can be recommended without restriction for unilateral pelvic reconstructions. The functional early results of bilateral aorto-femoral Goretex-Y bifurcation grafts in 50 cases after 2 years are encouraging. Long-term results are still pending. Reports of other groups using this material as aorto-bifemoral substitute are not yet available. The functional results with PTFE for femoro-popliteal grafts are not satisfactory: 35% after 2.5 years. Extra-anatomical bypasses yielded 70% one-year functioning rate. Especially the ring-or spiral-armoured PTFE grafts seem to be suitable for these reconstruction procedures.

Aged↗

PubMed1984

Prostacyclin-synthesis-stimulating plasma factor in patients with different stages of hepatic coma.

In patients with acute hepatic coma the prostacyclin synthesis stimulating plasma factor is significantly enhanced. This increased activity has been verified by using various test systems. However, there is no correlation between the actual plasma factor activity and the coma stage, respectively. The increase of plasma factor activity in these patients might account at least in part for the increased bleeding tendency seen in these patients.

Adolescent↗

PubMed1984

[Value of digital subtraction angiography in extra-anatomic bypass].

DSA is a well-established diagnostic procedure. A special indication and technique was employed in the application of DSA, using a low-dose contrast medium in 11 patients with extra-anatomic arterial reconstructions (3 axillofemoral, 4 femoro-femoral suprapubic cross-over bypasses, 4 obturator bypasses). This approach has not been previously described in literature. The authors performed direct puncture of the very proximal part of the bypass with a small (0.6 mm.) "subcutaneous" needle. Less than 2 ml of contrast medium was applied, and DSA was accomplished in several positions. In 11 patients high-quality imaging of the entire extra-anatomic bypass was achieved. Advantages of the procedure are: 1. Minimal dose of contrast medium (1-2 ml.). 2. Possibility of angiography even during anticoagulant therapy. 3. Complete imaging of extended bypass procedures with minimal discomfort to high-risk patients.

Aged↗

PubMed1984

[Fine relief of the stomach and diagnosis of gastritis. A radiologic-endoscopic-histologic comparative study].

To assess the sensitivity of radiology in diagnosis of gastritis within 2 hours endoscopy and biopsy of the stomach and double contrast barium meal were performed. The diagnosis was established of the morphologic picture of the areae gastricae, which were sufficient visible in 33 out of 50 cases (66%). In 7 patients radiologic findings were normal, 13 patients showed superficial gastritis, 10 patients had superficial gastritis with signs of atrophy and in 3 patients there was an erosive gastritis. In all 33 patients (100%) there was a complete correlation of radiologic and endoscopic findings, in 24 out of 33 cases (73%) even correlation between radiologic and histologic classification. These results are discussed and confrontated with literatures.

Adult↗

PubMed1984

[Arterial spasm caused by administration of DHE-heparin in a tibial fracture].

A 38 years old white woman suffered a tibial fracture which was primarily managed by traction therapy. 3 X 5000 IU Heparin DHE was given as prophylaxis against thromboembolism. 6 days after administration of the drug a severe arterial spasm (documented by arteriography) with high-grade ischaemia of the left leg occurred. Successful arterial dilatation with a Fogarty catheter within the entire infragenual region down to the foot arteries was performed and consecutively during the same anaesthesia the intramedullary stabilisation using an interlocking nail was also performed. 8 months later the patient was free from symptoms, the fracture had healed, and the function was unrestricted. All pulses were palpable and the ultrasound Doppler index was greater than 1. In conclusion, we recommend in arterial spasm during heparin DHE therapy, immediate operative exposure of the vessel--if possible under local anaesthesia--and adequate vascular surgery as balloon catheter dilatation.

Adult↗

PubMed1984

Postoperative assessment of below-knee bypass grafts.

Our results seem to demonstrate that, even when healthy or arteriosclerotic arteries tolerate knee flexion without any impairment of blood flow, all bypass materials, to a certain extent, have a tendency toward morphologic changes, such as kinking, looping, stenosis and decrease of peripheral blood flow. Reocclusion in below-knee reconstruction, which cannot be explained by poor outflow situation or technical faults, might be related to the graft material used as well as hemodynamic changes caused by flexion of the knee joint. With the use of ASV grafts, these changes are minimal and of little or no clinical importance; when HUV is used, these changes are more distinctive and might, in some instances, be the cause of reocclusion. This could explain the difference in the late results with the use of ASV or HUV. The results of reinforced PTFE still await evaluation. However, it should be kept in mind that the results in addition to the already mentioned influences are also caused by neointima proliferation and progression of the disease.

Aged↗

PubMed1984

[The PTFE-Y bifurcation prosthesis: early results].

During the past 2 years (April 1981-March 1983) 50 PTFE Y-grafts were implanted. The early results are good. Except one graft limb occlusion (8 months postoperatively), which was successfully managed by thrombectomy, all grafts are functioning well or did so until death. 5 patients (age 70-84 years, aortic aneurysm, additional vascular surgery) died 1 day to 8 weeks postoperatively. The death was not specifically related to the material of the new prosthesis. Advantages of PTFE are: a) no need of preclotting; b) absolute tight body of the prosthesis even in the heparinized patient; c) thrombectomy is easy to perform. Important technical details, mandatory for a safe operative procedure and for good functional as well as morphological results, are reported.

Adult↗

PubMed1983

[Preliminary experience with biological omental investment as a therapeutic procedure for infected lesions in vascular surgery].

Description of 8 patients, demonstrating deep infections following vascular reconstructive procedures. The classical method of treating these consists of removing all foreign material and circumventing the lesion by extra-anatomic bypass. A long extra-anatomic conduit needs a good run-off, therefore alternative methods of treatment are sometimes indicated, e.g. transposition of the omentum. In 8 instances healthy omentum was used to cover the infected conduit in order to preserve the reconstruction and to obtain healing of the wound. The procedure was successfully employed in 4 cases. Solitary infections healed without complications (3 patients). Out of 5 patients showing the catastrophic sequence of events - infection plus exsanguinating hemorrhage - only one was managed successfully.

Adult↗

PubMed1983

Bleeding aneurysm of the axillary artery, managed by a combined approach: interventional radiology and extra-anatomic bypass.

Twenty-two years after an obvious radical mastectomy with axillary lymph node dissection and postoperative conventional radiotherapy for carcinoma of the right breast, an 80-year-old lady was admitted because of the third bleeding episode within one year originating from the axilla. An aneurysm from the axillary artery was identified as the source of hemorrhage. Since the sites of irradiation had to be avoided, an extra-anatomic reversed saphenous vein graft was run from the right common carotid to the brachial artery. In the same session the bleeding was finally controlled by therapeutic embolization of the aneurysm using Gianturco-Anderson-Wallace coils. The postoperative angiogram showed the patent graft. Bleeding did not reoccur during the follow-up period of 17 months.

Aneurysm↗

PubMed1983

Extended extraanatomic arterial reconstruction: subclavian artery-bifemoro-crossover-popliteo-tibial-PTFE-bypass.

In a high risk patient an extended extraanatomic PTFE (ring armored) bypass was performed for limb salvage. The right subclavian artery served as donor vessel to the left tibial anterior artery in a crossover suprapubic fashion. A total of 7 anastomoses in this subclavian bifemoro-crossover popliteo-crural reconstruction yielded a high flow situation as well as good function with a palpable dorsalis pedis artery pulse and a postoperatively increased ankle-brachial pressure index of 0.9, 8 months postoperatively. During the 9th postoperative month the distal part of the reconstruction occluded and the left leg was amputated below the knee. However, limb salvage was achieved for 9 months. Several points are discussed in connection with long-term functioning.

Arteriosclerosis↗