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Biomedical subjects

P Plagnol

Publications and source records attributed to P Plagnol.

At least 19 recordsLinked to original sources
PubMed1999

Autogenous valve reconstruction technique for post-thrombotic reflux.

Post-thrombotic reflux in deep veins of the lower extremities cannot be treated by in situ valvuloplasty because of valve degeneration. The outcome of transplantation and transposition of segments with valves is controversial. From feasibility tests in animals and fresh human cadavers we have developed an autogenous valve reconstruction technique. The valve is fashioned from the proximal end of the greater saphenous vein that is left attached to the femoral vein, invaginated, and fixed to the venous wall. This technique provides a competent bicuspid valve. In a series of 19 patients operated on in 1995 we performed 20 valve reconstruction procedures at the level of the femorosaphenous junction by invagination of a fragment from the proximal end of the greater saphenous vein in the common femoral vein. Mean follow-up time was 10 months. No complications were observed. All femoral veins were patent and competent except one in which mild reflux was observed because of insufficient valve size. Further follow-up is needed to confirm the efficacy of this simple, new technique.

Animals↗
PubMed1996

[Villous adenoma of the duodenum. Apropos of a case].

We report a case of recurrent villous tumors (1989-1995) of the second duodenum. The diagnosis of these rare tumors was obtained by endoscopy. Risk of recurrence and degeneration raise the question of surgical or endoscopic treatment.

Adenoma, Villous↗
PubMed1994

[Leiomyoblastoma of the stomach. Diagnosis and therapy].

Leiomyoblastoma is a rare tumour of the stomach which general by develops in an exogastric location. We report a case in a 60-year-old patient who was seen for dark stools and acute anaemia. The tumour was located in the antrum and developed into the endogastric mucosa with ulceration. The extemporaneous examination revealed leiomyoblastoma of the stomach. A triangular resection of the antrum was performed. The diagnosis was confirmed by the pathology examination. Based on a review of the literature, we recalled the latest advances in diagnosis and therapy for leiomyoblastoma of the stomach.

Humans↗
PubMed1990

Treatment of stage II chronic arterial disease of the lower limbs with the serotonergic antagonist naftidrofuryl: results after 6 months of a controlled, multicenter study.

A study was carried out in patients with intermittent claudication (Fontaine's stage II). The atheromatous origin of the disease was confirmed and localized by angiography or Doppler. One hundred eight-three patients were selected initially (day -30) with a pain-free walking distance on a treadmill (at a speed of 3 km/h and a slope of 10%) ranging from 150 to 300 m. During the first month (washout period) all patients received two placebo tablets daily. At the end of this run-in period (day -30; day 0) and after checking walking distance stability (allowed variation: 20% between the two measurements), patients were included in the study. According to this criterion, 112 patients were selected and 94 remained during the whole study. The study was designed in double-blind, using two parallel, randomly selected groups. Fifty-two patients received naftidrofuryl (2 x 316.5 mg tablets daily with meals) for 6 months; 42 patients received placebo under the same conditions. During this period, clinical and paraclinical examinations were carried out every quarter (day 90 and day 180). After checking the initial homogeneity of the naftidrofuryl and placebo groups, the comparison between the two groups indicates a significant improvement in the naftidrofuryl group after 3 months and 6 months of treatment, for the pain-free walking distance. For the maximal walking distance, a significant improvement was found at day 180. Nonparametric analysis (chi 2 test) also indicated a significant improvement for the naftidrofuryl group. These results confirm that naftidrofuryl is beneficial in the treatment of patients with chronic arterial disease.

Adult↗
PubMed1975

[Familial reno-vascular hypertension (author's transl)].

The authors report a case of hypertension due to dysplasia of the renal arteries in a young man, and found the same disease in siblings. Two sisters and one brother also had renal hypertension, whereas the other relatives were unaffected. Two similar cases found in the world literature, did not permit the authors to determine the cause of this disease. This case is reported in order to stimulate research and the discovery of new cases.

Adult↗