Studies of cardiopulmonary and platelet function in thalassemic children.
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Adolescent↗
Biomedical subjects
P Pintadit
Publications and source records attributed to P Pintadit.
Platelet function tests in thalassemic children.
Platelet changes in thalassemia included prolongation of bleeding time (30%), thrombocytosis (29%), decreased platelet retention (79%), and normal PF3 release. Platelet aggregation was found to be hyperaggregation in 50%, normal in 22%, and hypoaggregation in 28% of the studied patients. Platelet changes in thalassemia can be hyper-, normal, or hypofunction. The changes are likely to be related to many factors, particularly to the progress of the disease. Platelet hypoaggregation may lead to a bleeding problem. Platelet hyperaggregation and thrombocytosis were prominent in the splenectomized patients and/or the severely anemic group; antiplatelet drugs may be indicated in these patients.
Adolescent↗
Fresh dried plasma: a solution for the shortage of blood products in developing countries.
The availability of blood products for replacement therapy of hemophilia and allied disorders is still a formidable problem in most developing countries which consist of 80% of the world population. Fresh dried plasma (FDP) is a lyophilized form of fresh frozen plasma which can be stored at 4 degrees C, whereas fresh frozen plasma must be stored at -20 degrees C. A large-scale production of FDP from single units of fresh frozen plasma was achieved by the National Red Cross Blood Center in Thailand. This paper describes the method of preparation, biochemical and blood coagulation properties of FDP during one-year storage as well as its clinical usefulness. A batch of 179 bottles of FDP stored at 4 degrees C for one week, 3, 6, 9 and 12 months was studied in order to determine the biochemical and blood coagulation parameters. FDP has pH higher than that of fresh frozen plasma, but its value is within the safety range for infusion. Electrolyte and protein levels were comparable with those of fresh frozen plasma. Coagulant activities of factors I, II, V, VII, VIII, IX and X were about 10% lower than those of fresh frozen plasma; however, they are in the acceptable therapeutic range and all were stable during storage at 4 degrees C for up to one year. Over 4,000 bottles of FDP were used with good clinical and laboratory response and no series side effects were observed in the treatment of bleeding in blood coagulation disorders and home care therapy of hemophilia.
Blood Preservation↗