[Histo-enzymatic study of muscles from autopsy of patients with various non-neuromuscular diseases].
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Biomedical subjects
Publications and source records attributed to P Pinelli.
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Cerebrospinal Fluid (CSF) and serum alpha 2-Macroglobulin (alpha 2M) was studied in patients affected by Multiple Sclerosis (MS) and other neurological diseases (OND) using Isoelectric Focusing followed by direct immunofixation. In the serum a simple broad band has always been observed; inside it several more stained subfractions were sometimes detected. In 74.3% of MS patients and in 65.7% of OND patients the CSF alpha 2-M was divided in two major bands. One corresponded to that observed in serum and the other was more anodal. The significance of this finding is discussed.
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Cerebrospinal fluid IgG/Albumin, IgG Index, Tourtellotte's formula and Schuller's formula have been calculated in 258 patients with definite Multiple Sclerosis and oligoclonal bands at isoelectrofocusing examination of cerebrospinal fluid. A step wise discriminant analysis was performed on single parameters and on a combination of IgG Index, Tourtellotte's and Schuller's formulas. The latter showed the highest percentage of right classification.
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