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Biomedical subjects

P Pigatto

Publications and source records attributed to P Pigatto.

25 records · Page 2Linked to original sources
PubMed1985

Lipoprotein metabolism and lipoprotein lipase in severe cystic acne.

In severe cystic acne we found low levels of high density lipoprotein-cholesterol (HDL-C) and apolipoprotein A (Apo-A) in the presence of normal total lipids. In a larger number of patients, we always observed significantly lower levels of HDL-C and Apo-A than in either age-matched controls or subjects with acne vulgaris. Since lipoprotein lipase is one major determinant of HDL concentration, we assayed the lipase activity in liver and extra-hepatic tissues by the method of Krauss et al. There was highly significant less total and hepatic lipase activity than in age-matched controls. HDL distribution was examined by zonal ultracentrifugation and a decrease in the HDL2 subclass was discovered. Since HDL are inversely correlated to atherosclerosis, cystic acne is one risk factor for atherosclerosis. The linkage between low HDL levels and severe cystic acne should be further investigated.

Acne Vulgaris↗
PubMed1985

Skin pathology in industrial workers exposed to synthetic corticosteroids.

Systemic and cutaneous side effects observed in some workers of a company producing synthetic corticosteroids are described. The production process and the results of clinical and laboratory investigations are shown. A high incidence of skin and internal disorders (erythema, telangiectasia, acne, purpuric lesions and inhibition of the pituitary-adrenal axis) were found.

Acne Vulgaris↗
PubMed1985

Role of the polymorphonuclear neutrophils in the phototoxic reaction in porphyria cutanea tarda.

We have compared the superoxide production of polymorphonuclear cells (PMNLs) from healthy donors, when incubated with either control or porphyria cutanea tarda (PCT) sera at 4, 24 and 48 hours after exposure in vivo to UVA light. Serum from UVA-irradiated (1-5 J/cm2) PCT patients generated significantly greater amounts of superoxides from PMNLs than serum from UVA-irradiated (8-12 J/cm2) normal controls. This indicates that serum factors activated by porphyrin plus UVA stimulate neutrophilic granulocytes to liberate superoxides, triggering a series of events that cause tissue damage. The vascular lesions in patients with PCT could be, at least in part, due to this cytotoxic effect.

Adult↗
PubMed1980

Levels of activity of the polyamine biosynthetic decarboxylases as indicators of degree of malignancy of human cutaneous epitheliomas.

The activities of ornithine decarboxylase and of S-adenosyl-L-methionine decarboxylase in human normal epidermis, in basal cell epitheliomas, and in squamous cell carcinomas of human skin have been compared. All 3 types of tissues have characteristic levels of each of these enzymes. The normal epidermis had the lowest levels of both ornithine decarboxylase and S-adenosyl-L-methionine decarboxylase activities. The levels of the polyamine biosynthetic decarboxylases in basal cell epitheliomas were significantly higher than those of normal epidermis, but at the same time significantly lower than those present in squamous cell carcinomas. These results support the conclusion that in epithelial malignant tumors of human skin the extent of the increase in the activities of polyamine biosynthetic decarboxylases is well correlated with the neoplasm's growth rate, which is faster in the squamous cell carcinomas than in the basal cell epitheliomas.

Aged↗