Via the refinement process of the monomer form of an arginine-vasopressin-like insect factor, the paper analyses the most relevant NMR information to define the solution structure of a flexible peptide. The relative importance of the different NOE constraints is discussed.

Animals↗

PubMedDate not supplied

The use of proton chemical shifts to define the solution structure of a dimeric peptide.

For flexible peptides, nuclear Overhauser Effects (NOE) experiments do not provide enough information to ensure a correct definition of their solution structure. The use of distance constraints, derived from the knowledge of proton chemical shifts, is developed to restrict the number of possible conformations. In the case of flexible molecules, randomization appears as an important factor of the correct estimation of the chemical shifts from the 3D structure. The refinement of the solution structure of the highly flexible AVP-like parallel dimer is described to illustrate this process.

Arginine Vasopressin↗

PubMedDate not supplied

An epidemic model with fatal risk.

A new epidemic model is developed that describes the spread of an infectious disease with fatal risk. The model includes as extreme cases the standard general epidemic process (for diseases that confer immunity after infection) and the fatal epidemic process (for diseases that lead inevitably to death). Both deterministic and stochastic versions are examined. First, attention is paid to the temporal and final states of the epidemic. Then the existence of a threshold phenomenon and the qualitative effect of the fatal risk are investigated.

Communicable Diseases↗

PubMedDate not supplied

[The patient with Hansen's disease confronts his distress].

This article is about the effect of Hansen's disease on the personality of 29 patients of the Institute of Applied Leprology of Dakar, Foundation of the Order of Malta. This approach to the distress of these patients was done by an inquiry based on sociocultural and clinical variables and compared to a study composed of tubercular and psychiatric patients. This study reports four distress levels (loss of identity, loss of object, forlornness, culpability) which are distinguished by sex and age. The actual analysis of the experience of this distress shows the importance of support of the traditional representation of these leprous patients' psychology.

Guilt↗

PubMedDate not supplied

[Reflections on anticoagulant treatment experience in medico-surgical resuscitation].

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Adolescent↗

PubMedDate not supplied

[Exceptional digestive hypochloremia].

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Adult↗

PubMedDate not supplied

[Halothane vaporizers].

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Anesthesia, Inhalation↗