[Current status of direct revascularization of the myocardium using aortocoronary bypass].
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Coronary Artery Bypass↗
Biomedical subjects
P Perrier
Publications and source records attributed to P Perrier.
HLA typing in a new family with Fletcher factor deficiency.
In a nonrelated white family, the Fletcher factor level in the father was 0.41 U/ml and in the mother, 0.30 U/ml (controls, 0.75-1.25 U/ml). One sibling with recurrent epistaxis had a level of 0.012 U/ml, whereas the other without tendency to spontaneous bleeding had levels between 0.75 and 0.32 U/ml. This suggests autosomal recessive transmission with clinical symptoms when the defect is homozygous. HLA antigens were studied to determine whether characters of the histocompatibility system and this defect are linked: we determined that the gene(s) of the disease is (are) not shared on the HLA complex.
Adult↗
[2 cases of colitis caused by Clostridium difficile during antibiotic therapy].
Defined the most important clinical, endoscopic and pathological aspects of antibiotic-associated colitis, the AA. examine the Clostridium difficile as the etiological agent. The range of examination has been limited to two cases of pseudomembranous colitis, a diagnostic and a therapeutic evaluation is suggested for patients with AAD and PMC. Furthermore the importance of a strictly observance of hospital hygienic rules in the prevention of such pathological cases is strongly stressed.
Adult↗
A study of immuno-genetic tracers in a pair of discordant twins with blood chimera.
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Child, Preschool↗
Antigen Nou. A new high frequency Rh antigen.
Serum from a D--/D-- allo-immunized woman is found to contain 3 separable antibodies: anti-e, anti-Ee (Rh 17) and a third component which, in contrast to 5 other sera from people with Rh deleted phenotypes, reacts strongly with red blood cells from Mrs Nou., a DIV(C)--/DIV(C)--black woman. The latter component studied by elution and coagglutination using Nou. cells reacts with a hitherto unrecognized public antigen within the Rh system. 2750 random donors, 2Rh mod. individuals and 17 people with public minus phenotypes in other blood group systems were found to express the antigen. 2 Dc--/Dc--, 4 D--/D-- and 4 Rh nul samples were non reactive. The identity of the antibody with anti-Hr (Rh 18) was ruled out since the original anti-Hr failed to react with Nou. red blood cells.
Agglutination↗
Allo antibodies in partially silent Rh phenotypes. Evidence for a possibly new high frequency Rh antigen.
Seven sera from 4 D -- --, 2 Dc -- and 1 DIV(C) -- immunized women were studied through extensive absorption-elution and coagglutination tests against a panel of common and depressed or deleted Rh phenotypes. A separable anti-e was regularly present in all sera together with an anti-Ee antibody which often showed stronger reactivity with e antigen. A possibly new anti-public Rh antibody was further separated in the serum from a D -- -- individual. The corresponding antigen is expressed on common, DIV(C) -- and depressed Rh phenotypes used, and is absent from Dc --, D -- -- and Rh null cells.
Female↗
[Anti-varicella-zona immunoglobulins. Discovery of antibodies and method of formation].
The screening of zoster's antibodies has been performed in blood donors population and persons convalescing from herpes zoster. The results show that 25% of blood donors and 83,5% of convalescents have respectively a titer of CF antibody of 8. Plasma units were pooled and the pool had a final titer of CF antibody of 16. Varicella zoster immunoglobulin prepared by alcohol fractionation had a fluorescent antibody titer of 1 024 and a CF antibody of 512. These results are discussed and compared with those of literature.
Adult↗
HD50 assay evaluation of the antigen Fy3 depression in Fyx individuals.
HD50 assays for the antigens Fyb and Fy3 were performed in a large number of Fyx homozygous or heterozygous individuals. A full correlation was found in quantitative expression of Fyb and Fy3 favouring the hypothesis of a Fybw Fy3w gene complex in the Duffy blood group system.
Blood Group Antigens↗
Preparation of varicella-herpes zoster immunoglobulin.
The efficacy of zoster immunoglobulin in prophylaxis of varicella and herpes zoster is reported by many authors. The screening for zoster's antibodies is performed in the blood donor population and in persons convalescing from herpes zoster. The results show that 25 per cent of blood donors and 83.5 per cent of convalescents, respectively, have CF antibody titer of l6. Varicella zoster immunoglobulin prepared by alcohol fractionation has a fluorescent antibody titer of 1,024 and a CF antibody titer of 512. These results are discussed and compared with those of the literature.
Adult↗
In vivo evaluation of a trileaflet mechanical heart valve.
Design goals for a mechanical heart valve include duplicating the hemodynamic performance of the natural valve, eliminating the need for anticoagulants, and maintaining safety. The Lapeyre-Dassault (Dassault-Aviation, Paris, France) prosthetic valve, undergoing development, addresses these goals. The unique trileaflet design consists of a solid titanium ring and three leaflets. Prototypes of the valve fabricated with Delrin leaflets were implanted in the mitral position in six calves (70-90 kg). Four calves (Studies 1, 2, 3, 5) had long-term survival of 165, 158, 219, and 281 days, respectively. Two calves were killed, one on Day 37 and one on Day 39, after complications unrelated to the valve developed. In all calves heparin was given intravenously to maintain partial thromboplastin time at 1.5 to 2.0 x baseline for approximately 1 week. In Studies 1 and 2 full anticoagulation and antiplatelet therapy was given (orally administered sodium warfarin to maintain prothrombin time at 1.5 to 2.0 x baseline, along with aspirin (1 g/day) and dipyridamole 400 mg/day). In Study 3, all anticoagulation and antiplatelet therapy was discontinued at 1 month after implant. In Study 5, no anticoagulation therapy was given after the initial week of intravenous heparin; however, antiplatelet therapy was started on the fifth postoperative month and maintained until the study's end at 9 months. At 1, 2, 3, and 5 months, the mean plasma free hemoglobin level in the four long-term animals was 5.0 +/- 2.16, 6.0 +/- 3.83, 8.5 +/- 4.93, and 11.3 +/- 6.74 mg/dl, respectively. Hemolysis was not a problem. Valve performance during normal activity was excellent in all the calves, as evidenced by echocardiography and the overall appearance of good health. In the four completed long-term studies, left heart catheterization showed a mean valve pressure gradient of 11.57 +/- 1.26 mmHg and no apparent valvular regurgitation. Histopathologic examination of major organs showed no evidence of thromboembolic events. This study shows that the innovative design of this trileaflet valve performed well in initial in vivo testing, justifying further development.
Animals↗