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Biomedical subjects

P Peeters

Publications and source records attributed to P Peeters.

At least 55 records · Page 3Linked to original sources
PubMed1995

Severe Smith-Lemli-Opitz syndrome with prolonged survival and lipid abnormalities.

We have studied a girl with multiple congenital anomalies, growth and mental deficiency, characteristic facial anomalies, cataracts, cerebellar atrophy, and severe hypocholesterolemia. Death occurred at age 7 years. After excluding several syndromes, i.e., peroxisomal disorders, mevalonic acidaemia, and Marinesco-Sjögren syndrome, it is concluded that this girl had severe Smith-Lemli-Opitz Syndrome (SLOS) with exceptionally long survival. This diagnosis was confirmed through assay of 7-dehydrocholesterol in cultured fibroblasts.

Abnormalities, Multiple↗
PubMedDate not supplied

Listeria monocytogenes infection of a prosthetic vascular graft.

A 75-year-old man was admitted for acute ischaemia of his right leg for which he had undergone vascular prosthetic surgery at another hospital, ten and three years before. Cultures of the thrombosed graft and the clots removed on re-operation were positive for Listeria monocytogenes. After parenteral treatment with amoxicillin-clavulanic acid and gentamicin, the patient died from cardiorespiratory failure.

Aged↗
PubMedDate not supplied

Calcium channel blockers in the prevention of end stage renal disease: a review.

Hypertension and high levels of proteinuria are independent risk factors for accelerated progression of renal failure. There is increasing evidence that strict control of both blood pressure (BP) and proteinuria are beneficial in slowing the rate of progression of chronic renal disease in diabetic as well as non-diabetic nephropathy. The angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin 2 receptor blockers (ARB) have clearly demonstrated their beneficial effect on both reduction of BP and proteinuria. The calcium channel blockers (CCB) have individual pharmacological and therapeutic properties that may vary, but as a group they are effective antihypertensive agents in patients with renal disease. Their effects on the kidney may extend beyond BP reduction alone. Current studies suggest that CCB do not worsen the progression of renal disease but may rather provide benefit when systemic BP has been tightly normalised. The non-dihydropyridine calcium channel blockers (NDHP), diltiazem and verapamil, slow the progression of type 2 diabetic nephropathy with overt proteinuria almost to a similar extent as observed with ACE-I. The dihydropyridine calcium channel blockers (DHP) have a variable effect on proteinuria. Pharmaceutical compounds, which inhibit the renin-angiotensin system (RAAS), remain the drugs of first choice in the treatment of hypertension and/or proteinuria in chronic nephropathy. However, a combination of two or more drugs is almost always required to attain sufficient BP reduction. CCB may have an advantage in combination with ACE-I and/or ARB.

Angiotensin Receptor Antagonists↗
PubMedDate not supplied

Transplantation as a therapeutic option for diabetic nephropathy.

Diabetic nephropathy affects both type 1 and type 2 diabetic patients with a frequency of 20-30%. The first sign is microalbuminuria within a range of 30-300 mg/24h, frequently evolving towards frank proteinuria and renal failure. Tight glucose control, control of arterial hypertension with the use of ACEi or ARB can retard progression. Once renal failure is established, kidney transplantation can be considered for type 1 and type 2 diabetic patients. Quality of life and survival are improved with this procedure. In type 1 diabetes, simultaneous grafting of a kidney and pancreas considerably improves quality of life and diabetic complications. Surgical and infectious complications are sporadic drawbacks of this procedure. Pancreas transplantation alone (PTA) remains controversial, since a retrospective study in 2003 by Venstrom concluded that survival for PTA patients is worse than for comparable patients remaining on the waiting list. PTA can be considered for type 1 diabetic patients without advanced renal failure with severe and frequent metabolic instability (hypoglycaemia, ketoacidosis). Islet transplantation is still an experimental but promising procedure in highly selected patients, avoiding major abdominal surgery.

Diabetes Mellitus, Type 1↗
PubMedDate not supplied

Endoleaks after endoluminal repair of abdominal aortic aneurysms: diagnosis and treatment.

Endoleaks currently present one of the major problems related to endoluminal treatment of abdominal aortic aneuryms (AAA). The incidence and fate of endoleaks stress the importance of long term follow-up. In this article the authors discuss which imaging techniques can best be used for surveillance and how endoleaks should be classified. Furthermore the necessity of treatment as well as treatment options are discussed.

Aortic Aneurysm, Abdominal↗
PubMedDate not supplied

Cardiac tamponade as the first manifestation of bronchogenic carcinoma.

A case of cardiac tamponade as the first manifestation of bronchogenic adenocarcinoma is presented. Diagnosis of metastatic pericarditis with effusion was made by echocardiography and cytology of the pericarditis fluid. Because of rapid recurrence of the effusion, a pericardial window was created. This operation was well tolerated by the patient. A short discussion of metastatic pericarditis is given.

Adenocarcinoma↗