Search PubMed⌕ Search

Biomedical subjects

P Patamasucon

Publications and source records attributed to P Patamasucon.

24 records · Page 2Linked to original sources
PubMed1982

Pharmacokinetics and bacteriological efficacy of N-formimidoyl thienamycin in experimental Escherichia coli meningitis.

The pharmacokinetics and bacteriological efficacy of N-formimidoyl thienamycin were determined in rabbits infected with Escherichia coli K1. After a single intravenous dose of 25 mg/kg, a peak N-formimidoyl thienamycin concentration in cerebrospinal fluid (CSF) of 2.5 micrograms/ml was attained at 45 min. The penetration into CSF was calculated to be 31%. In animals that received continuous intravenous infusions of the drug for 9 h, the mean CSF concentration was 8.2 microgram/ml, and the CSF bactericidal titers against the E. coli K1 strain were from 1:16 to 1:32. This infusion produced a reduction in the numbers of E. coli in the CSF of 4 log10 colony-forming units per ml. N-Formimidoyl thienamycin might prove to be useful for therapy of meningitis caused by E. coli and other susceptible bacteria.

Animals↗
PubMed1981

Pharmacokinetics of erythromycin ethylsuccinate and estolate in infants under 4 months of age.

We studied the pharmacokinetics of erythromycin estolate and ethylsuccinate suspensions in infants under 4 months of age who were being treated for chlamydial infections or pertussis. We conducted our studies after the initial dose of 10 mg/kg and subsequently during steady-state treatment. The estolate preparation resulted in higher peak concentrations in sera, and its absorption and elimination half-lives were longer. Peak concentrations occurred 3 h after a dose with the estolate preparation and 1 h after a dose with the ethylsuccinate preparation. The area under the curve for the estolate preparation was about three times greater than that for the ethylsuccinate preparation. Based on these findings, we recommend that erythromycin estolate suspensions be given to young infants at 8- or 12-h intervals (30 mg/kg per day in three divided doses or 20 mg/kg per day in two divided doses) and that erythromycin ethylsuccinate is best given at 6-h intervals (40 mg/kg per day in four divided doses).

Chlamydia Infections↗
PubMed1981

Streptococcal submandibular cellulitis in young infants.

Six infants with streptococcal submandibular cellulitis and bacteremia were managed in our institution during a seven-month period. Five uncomplicated cases were caused by group B beta-hemolytic Streptococcus, and one rapidly progressive case of Ludwig's angina was caused by group A Streptococcus. Recognition of this characteristic clinical presentation of group B streptococcal infection may be beneficial in the management of such patients.

Ampicillin↗
PubMed1981

Cefuroxime therapy of gonorrhea and coinfection with Chlamydia trachomatis in children.

Twenty-seven episodes of gonorrhea occurring in children less than 15 years of age were treated with an intramuscular injection of cefuroxime, 25 mg/kg. Gonococci were eliminated from genital, pharyngeal, and anal sites in all cases. Cefuroxime was well tolerated and no side effects were observed. Coinfection with Chlamydia trachomatis was found in nine patients (33%). Among the seven patients with chlamydial genital infection, postgonococcal symptoms persisted in three children (43%). On patient of the five with chlamydial anal infections were successfully treated with trisulfapyrimidines.

Adolescent↗