Search PubMed⌕ Search

Biomedical subjects

P Paris

Publications and source records attributed to P Paris.

At least 19 recordsLinked to original sources
PubMed1995

Amantadine does not reduce cocaine use or craving in cocaine-dependent methadone maintenance patients.

We tested the efficacy of amantadine to reduce cocaine use or craving in cocaine-dependent methadone maintained patients. Two doses of amantadine (200 mg p.o. daily, n = 16, and 200 mg p.o. bid, n = 21) were tested against placebo, n = 22, in a random assignment, double-blind clinical trial lasting nine weeks. Amantadine was well tolerated. However, neither dose of amantadine was more effective than placebo in reducing cocaine use and craving.

Adult↗
PubMed1995

Pain after laparoscopic cholecystectomy: characteristics and effect of intraperitoneal bupivacaine.

Although pain after laparoscopic cholecystectomy is less intense than after open cholecystectomy, some patients still experience considerable discomfort. Furthermore, the characteristics of postlaparoscopy pain differ considerably from those seen after laparotomy. Therefore, we investigated the time course of different pain components after laparoscopic cholecystectomy and the effects of intraperitoneal bupivacaine on these different components. Forty ASA physical status grade I-II patients were randomly assigned to receive either 80 mL of bupivacaine 0.125% with epinephrine 1/200,000 (n = 20) or the same volume of saline (n = 20) instilled under the right hemidiaphragm at the end of surgery. Intensity of total pain, visceral pain, parietal pain, and shoulder pain was assessed 1, 2, 4, 6, 8, 24, and 48 h after surgery. Analgesic consumption was also recorded. Patient data were similar in the two groups. In the saline group, visceral pain was significantly more intense than parietal pain at each time point; visceral and parietal pain were greater than shoulder pain during the first 8 h postoperatively. Intraperitoneal bupivacaine did not significantly affect any of the different components of postoperative pain. Analgesic consumption was similar in the two groups. This study demonstrates that visceral pain accounts for most of the pain experienced after laparoscopic cholecystectomy. Intraperitoneal bupivacaine is not effective for treating any type of pain after laparoscopic cholecystectomy.

Abdominal Muscles↗
PubMed1995

[Hypnotherapy].

Explore the source record for details and available documents.

Analgesia↗
PubMed1993

[Evolution of depression in the child and adolescent].

Outcome of depressive disorder in adolescents is now better known. Despite methodological differences between studies there is an agreement to emphasize frequency of relapse and recurrence in the follow-up (50 to 60%). Others modalities have also been described, anxiety disorders seemed to be the more frequent. For some authors, affective disorder in adolescents could presage manic depressive illness. Psychosocial functioning after the follow-up seems to be impaired as well as in professional, relational, or social fields. These data suggest a clear distinction between affective states in adolescents and symptoms related to psychological transformations of adolescence. We have conducted a follow-up study with adolescents hospitalized in the child and adolescent psychiatric department of R. Debré hospital, for major depressive episode (MDE) or dysthymic disorder (DD). On the 122 patients meeting initially inclusion criteria, 75 have been evaluated after one year follow-up at least. Duration of the follow-up was on average 4 years. 44 met initially DSM III and DSM III-R criteria for MDE and 31 for DD. Rating has been done during a phone interview with a standardized questionnaire. We did use criteria defined by Prien et al. (1984) for relapse, recurrence and remission. Our results showed a good short-term outcome in both groups (72.7% remission in MDE and 80.6% in DD). Relapse rate was superior in the first group. At the end of the follow-up, cumulative probability of recurrence was 52.9% in MDE group and 35.7% in DD group. Chronic evolution was more frequent in TD group.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1992

Split-liver orthotopic liver transplantation: how to divide the portal pedicle.

It is possible to obtain two good-quality hepatic transplants from a single cadaveric liver by separation of right and left lobes of the liver or section between the left medial segment and the left lateral segment medial to the umbilical cleft. We attempt to define the ideal basis of separation of the structures of the portal pedicle, based on anatomic study of 25 livers. Ideally, the following should be sectioned: the left portal vein, longer and more constant than the right; the right branch of the hepatic artery, larger and more constant than the left; and the left hepatic duct, being aware of the vascularization of the common hepatic duct. Use of the left portal vein necessitates the interruption of all left venous portal branches of segment I, which should be systematically resected. A section between the left medial segment and the left lateral segment interrupts all portal venous branches of the left medial segment, which should then be resected. Before hepatic division, a cholangiogram and arteriogram are indispensable to detect variations and avoid an extensive dissection that may endanger bile duct vascularity.

Bile Ducts↗
PubMed1992

Kinetic colorimetric assay of lipase in serum.

We describe a kinetic colorimetric method for assaying lipase (EC 3.1.1.3) activity in serum by using a natural long-chain fatty acid 1,2-diglyceride. In the presence of colipase, deoxycholate, and calcium ions, pancreatic lipase hydrolyzes the clear substrate solution to produce a 2-monoglyceride, which in turn releases glycerol by the action of a 2-monoglyceride lipase. Glycerol is then assayed by a sequence of enzymatic actions (glycerol kinase, glycerol phosphate oxidase, and peroxidase) that produce a violet quinone monoimine dye with peak absorption at 550 nm. The method features zero-order reaction kinetics, provides a simple and rapid assay with an extended dynamic range, is specific and precise, gives results that correlate well (r greater than or equal to 0.99) with those of methods in which emulsified triolein is the substrate, and lends itself readily to automation. For all these reasons, the method seems highly suitable for routine use in clinical laboratories.

Calcium↗
PubMed1991

A prehospital model of intraosseous infusion.

STUDY OBJECTIVE: Before the implementation of an intraosseous infusion protocol by the City of Pittsburgh paramedics, we undertook a study to compare the establishment of a simulated intraosseous infusion in three different prehospital settings. The purpose of this study was to determine the time to establish an intraosseous infusion and the success rate at the scene and en route to the hospital using this model. DESIGN: Prospective study. SETTING: Three prehospital scenarios: classroom (scene); a medic unit traveling at 25 mph and making slow, steady turns (turns); and a medic unit traveling at 30 to 35 mph with sudden stops and starts (stop and go). TYPE OF PARTICIPANTS: Paramedics and emergency medicine residents. MEASUREMENTS AND MAIN RESULTS: Successful placement of the IO needle was confirmed by the aspiration of marrow or the free flow of 5 to 10 mL of normal saline without extravasation into the surrounding tissue. The procedure was timed from skin entry to establishment of infusion. All participants were successful in establishing IO infusion, with 84.8% of infusions achieved in less than one minute in all settings. The scene had somewhat shorter mean and median times and a higher first-attempt success rate, but the differences between scenarios were not significant. CONCLUSION: Using a simulated model, IO access can be established successfully in the prehospital setting. The minimal time delay in establishing IO infusion may make it an appropriate technique for use at the scene or en route to the hospital.

Allied Health Personnel↗