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Biomedical subjects

P Panchev

Publications and source records attributed to P Panchev.

At least 73 records · Page 4Linked to original sources
PubMed1994

[Initial clinical studies of the preparation Immucyst for immunotherapy in patients with carcinoma in situ (CIS) of the bladder].

Over a 12-month period, thirteen patients, 10 men and 3 women, with recurrent surface transitional cell carcinomas of the urinary bladder in conjunction with CIS, are picked out and subjected to treatment. Distribution of the patients: primary multiple carcinomas combined with CIS, Ta-T1/G1-G2-4 cases; recurrent multiple carcinomas, with CIS, Ta-T1/G2-two, recurrent multiple carcinomas, combined with CIS, Ta-T1/G2-five, and T1/G3-two cases. In all instances transurethral resection (TUR) of both visible carcinomas, and CIS areas, is performed. Induction Immucyst therapy is carried out according to protocol: 3 vials BCG vaccine, dissolved in 50 ml serum, inserted intravesically once weekly over 6 weeks. The fluid is retained by the patients for up to 2 hours. Therapy is commenced within 7-14 days after TUR. Cystoscopy, cytology and biopsy of suspected areas ar done at 3, 6 and 12 days. Six of the patients reported on undergo 12-month follow-up study. The remainder (6 cases) are followed up for periods ranging from 3 to 6 months. At the actual stage of study, twelve patients are free of recurrences, and present negative cytological findings. One patient alone with carcinoma stage T1/G3 develops recurrence, treated with TUR and laser coagulation followed by immunotherapy. Two thirds of the patients sustain transitory pollakiuria and dysuria, and one third-subfebrile temperature persisting for 48 hours.

Adult↗
PubMed1994

[Urethral strictures following transurethral resection of the prostate].

A series of 147 patients subjected to transurethral prostate resection (TUPR) are followed up for seven years with a special reference to urethral strictures development. The patients' age varies from 52 to 78 years, with an 18-month average postoperative observation term. The methods of diagnosis used comprise uroflowmetry, retrograde urethrography and urethrocystoscopy. Obstruction of the lower urinary ways and urethral strictures are documented in 16 cases (10 per cent). Usually, post-TUPR strictures occur within one to three months after the operation. A brief literature survey on the incidence rate of this complication, reported by other authors, along with a comparative assessment of the results, is done. The likely underlying causes involved, and the prophylactic measures against the complication are discussed.

Aged↗
PubMed1994

[Transurethral incision in primary bladder neck obstruction].

Sixty-one patients presenting primary obstruction of the neck of the urinary bladder are subjected to transurethral operative intervention and postoperative follow-up study in the period 1986 through 1990. The indications for performing transurethral incision of the bladder neck are established on the basis of subjective complaints against the background of data from uroflowmetry, miction cystourethrography and endoscopic study of the lower urinary ways. The obtained results point to an improvement of the subjective complaints in 74 per cent of the cases. In 78 per cent of the patients peak urinary flow exceeds 15 ml/sec. Repeated transurethral incision is necessitated in 8.1 per cent, and transurethral resection in the postoperative period is done in twelve patients (19.6 per cent). Postoperative strictures of the urethra are discovered in 8 patients (13.1 per cent), and retrograde ejaculation is documented in three patients (8.5 per cent) over the maximum observation term of 64 months. Postoperative hospitalization is average 3.2 days (range 2.7 to 5.9 days).

Adult↗
PubMed1993

[The indications for the surgical treatment of prostatic adenoma].

Proceeding from a comprehensive literature survey, an attempt is made to substantiate the single indications for operative treatment of prostate hypertrophy cases. Special attention is focused on the quantity of residual urine, clinical relevance of the uroflowmetric study, and individual assessment of the urologist, depending on his surgical experience. Last but not least important is grouping of the individual symptoms of prostate hypertrophy under the heading "prostatism" syndrome, since they serve not merely for preoperative evaluation, but also as an assessment criterion of the postoperative condition.

Cystoscopy↗
PubMed1993

[The modern diagnosis of stenosis and obstruction of the ureter].

Included in the study were 681 patients with stenosis and obstruction of the ureter (SOU), diagnosed at the Department of Urology, Clinical Center of Urology, University Aleksandrovska Hospital in Sofia for a period of 5 years. The diagnosis rested on clinical, laboratory, X-ray, radioisotopic, echographic, endoscopic and other investigations. Analysis of the clinical and laboratory data demonstrated an outstanding triad of clinical symptoms: pain (76.8 per cent), hematuria (74.0 per cent), dysuria (70.9 per cent). The laboratory data confirmed the standpoint of other authors that most common is the urinary tract infection, followed in incidence by microhematuria, leukocyturia and hemoglobin content lower than 10 mg %. The most common causative agents of infection were E. coli (29.8 per cent) and Proteus (26.28 per cent). The X-ray methods being used were excretory urography (76.8 per cent) and plain X-ray on kidney-ureter-bladder film (93.2 per cent of the patients). Excretory urography furnished information on the cause, degree and location of SOU and on the effect upon the kidney. It helped to determine the approach to treatment--conservative transureteral or operative.

Adult↗
PubMed1993

[The modern treatment of stenosis and obstruction of the ureter].

The methods used for treatment of stenosis and obstruction of the ureter (SOU) are: conservative treatment, extracorporal lithotripsy, transureteral operations, surgical management. The different genesis of the nosologic entities underlying--SOU requires adequate effective and organ preserving treatment. In the authors series of 681 patients the mot common approach to treatment und transureteral operations (46.7 per cent) with surgical treatment ranking next (44.5 per cent), presented by organ preserving, organ removing, palliative and reconstructive procedures. Third in incidence was extracorporal lithotripsy of ureteral calculi (31.3 per cent). Judirrdual conservative treatment was least common (7.6 per cent). As a result of treatment in 76 per cent of the patients with "mute kidney" renal and ureteral function were re-established after removal of the stenosis and obstruction of the ureter.

Adult↗
PubMed1991

[The place of interventional ultrasound in urology].

The search for new methods of diagnosis, treatment and prognosis and their introduction in practice is a stable process in world urologic practice. It was not until after the first echographic apparatuses were produced in the fifties that the introduction of interventional ultrasound in urology became feasible. The authors set themselves the task to study and summarize the possibilities of this method for treatment of diseases of the kidneys, upper urinary tract, bladder and prostate. Renal cysts were diagnosed by ultrasound in 312 patients; in 229 of them percutaneous puncture was performed under ultrasound control. To reduce relapses, different sclerosing substances were applied, peak success being obtained with tetraolean. For establishing the exact cause of obstruction of the upper urinary tract the authors used antegrade pyelography under ultrasound control in 92 patients. Percutaneous nephrostomy for drainage of the upper urinary tract, a new endourologic operation was performed in 67 patients. To raise the radical approach to transurethral resection of the prostate and of bladder tumors, intraoperative transurethral ultrasound control was adopted for all patients operated by this technique.

Adult↗
PubMed1990

[Cases of the regression of advanced bladder tumors (T2-T4) after the use of chemotherapy].

A. Yagoda reports that modern therapeutic schemas applied for treatment of bladder tumors have essentially increased the response rate: more than 50 per cent with full response (CRs), within the range from 28 to 40 per cent persisting for a period from 11 to more than 32 months. What appears new, noted by this author, is the complete disappearance of the tumor (restaging) following chemotherapy, demonstrated surgically and on pathologic examination. Proceeding from the current trends in the treatment of bladder tumors and the use of modern chemotherapeutic schemes, the authors describe 4 cases of regression of advanced tumors. This was based on criteria of clinico-laboratory assay, which included urethroscopy with transurethral echography and biopsy specimen examination, computer axial tomography of pelvis and kidneys, radioisotopic examination of kidneys, chest X-ray. Two patients received combined treatment by a scheme with methotrexate, biocysplatinum and biocarbazine; a three-year survival without relapse was recorded. The other two patients were treated using M-VAC scheme (methotrexate, vinblastine, adriamycin and biocysplatinum). They have been under observation for 18 months and had no relapse.

Aged↗
PubMed1989

[Retrograde ejaculation following transurethral surgery for bladder neck sclerosis].

A brief review of the literature on the physiology of ejaculation and the causes and treatment of retrograde ejaculation is made. Retrograde ejaculation following transurethral resection for bladder neck sclerosis is discussed in detail. Seventy four patients were under control for a period of 5 years--69 after transurethral resection and 5 after transurethral incision of the bladder neck. Retrograde ejaculation was observed in 8.6 per cent of the patients. The possibility to solve the fertility problems in young men, as well as to avoid this complication is discussed. Inferences are made and recommendations given for establishing the diagnosis, treatment and prophylaxis of this complication.

Adult↗
PubMed1989

[Postoperative sclerosis of the bladder neck in men].

Postoperative sclerosis of the bladder neck is an operative complication after removal of prostate adenoma. It was originally described by the American urologist Danslow in 1918. Personal experience is recorded in the diagnosis and treatment of 43 patients with postoperative sclerosis of the bladder neck for a period of four years. They have been treated at the Department of Urology of the Medical Academy in Sofia. Some basic methods of diagnosis of postoperative sclerosis of the bladder neck are discussed; transurethral methods of treatment--TUR and TUI--are considered the methods of choice. The postoperative results are based on the patients' complaints, on the amount of residual urine and on uroflowmetry.

Aged↗