Biomedical subjects

P Pacini

Publications and source records attributed to P Pacini.

134 records · Page 8Linked to original sources

PubMedDate not supplied

Cell kinetics in breast cancer.

In breast cancer the study of prognostic factors has been well developed during last years and many biologic and biochemical parameters have been analyzed. Cell kinetics parameters demonstrated the capability to select patients with different risk of evolution of the neoplasia and in some cases treatment protocols are established by means of proliferation rate. The present study deals with the determination of Thymidine Labelling Index in breast tumors mostly T1-T2 with negative lymph nodes. Results demonstrated that the proliferative activity is higher in younger patients, in T2 cancers compared to T1, and in ductal infiltrating forms compared to the other more frequent histotypes. A significant correlation has been observed between TLI and nuclear grade. The preliminary analysis of the prognostic value of TLI has been two performed using an experimental cut off that is able to discriminate groups of patients with overall survival rate of 67% and 88%, depending on the different proliferative activity of the tumor.

Breast Neoplasms↗

PubMedDate not supplied

[A morphological study of ciliary abnormalities in patients with immotile cilia syndrome].

The present study has the aim of studying the morphological aspects of ciliary abnormalities in patients affected by immotile-dyskinetik cilia syndrome. Five patients affected by primary ciliary dyskinesia have been studied, examining by TEM the cells obtained by bronchial brushing during fiberoptic bronchoscopy. Many types of anomalies have been observed, and a morphologic classification was proposed. The frequency of abnormal cilia appears to be correlated to the severity of respiratory pathology. The morphological anomalies are not specific for this pathology.

Adult↗

PubMedDate not supplied

The calibers of the common femoral, popliteal, and posterior tibialis arteries: a statistical investigation in 100 healthy subjects by color Doppler ultrasonography.

One hundred healthy subjects (50 men, 50 women; age range: 18 to 90 years) with no history of occlusive arterial disease of the lower extremities were examined. In each, the principal arteries of the lower extremities were measured by Doppler ultrasound. The difference between the dimensions of the arteries of the right with those of the left was generally not significant, although those of the right were consistently larger. The only exceptions were the common femoral arteries in both sexes and the posterior tibialis arteries in the men, where there was a statistically significant predominance of the right. As compared to those of the females, the arterial calibers of the male subjects were significantly larger (p < 0.01) for all the arteries examined. In both sexes, there was a statistically significant direct relationship between vessel caliber and age. There was no correlation between arterial dimension and body index.

Adolescent↗

PubMedDate not supplied

The blood-flow velocity analysis as a possible method for arterial calibre discovery. A statistical investigation in 108 human subjects by color-Doppler method.

Using Echocolordoppler, we have examined 108 subjects with stenosis of the Internal Carotid Artery (ICA). For each subject, age, sex, body weight, height, systolic and diastolic arterial pressure, as well as measures of original caliber of ICA, residual lumen and maximal systolic velocity (MSV) at the stenosis were recorded. In both sexes there was a highly significant correlation (p < 0.001) between MSV, percentage of stenosis, and residual lumen, while there was no correlation between MSV and arterial pressure, which could have modified interpretation of data. Linear regression analysis was performed to calculate total vessel caliber, whenever not directly measurable, from MSV and residual lumen.

Aged↗

PubMedDate not supplied

The inner diameter of human intracranial vertebral artery by color Doppler method.

In 50 healthy subjects the internal diameter of the intracranial vertebral artery were measured by echocolor doppler method. The diameter of left vertebral a. was greater than that of the right in most subjects (58%); the mean left/right difference was statistically significant (p < 0.05). Analyzing men and women separately, the difference remained significant only in women (p < 0.05). A significant correlation was found between vertebral a. diameter and sex (p < 0.01). The vertebral a. diameter had a tendency to increase with age, that reached significance only for the left vertebral one. No significant correlation was found between body surface area and vertebral a. diameter.

Adolescent↗

PubMedDate not supplied

Magnetic resonance angiographic evaluation of circulus arteriosus cerebri (circle of Willis): a morphologic study in 100 human healthy subjects.

The Circle of Willis was studied by Magnetic Resonance Angiography in 100 healthy subjects. In 41% of these cases, the arteries were arranged in the classically described way. In 21%, hypoplasia of the posterior communicating as. was noted, while in 13% the posterior cerebral as were found to originate from the internal carotid a.. In 9% of these cases, three anterior cerebral as. were present. In 3% the anterior communicating artery could not be identified, while the left posterior communicating artery was hypoplastic. In 2% the absence of a posterior communicating artery was associated with the origin of a posterior cerebral a. from the internal carotid. In another 2% the anterior cerebral as. were partially fused, and in yet another 2%, hypoplasia of both an anterior and a posterior cerebral a. was present. The remaining seven cases (7%), all different from each other, represented combinations of the above described variations. Statistical analysis indicated that anomalies occurred more commonly on the left than on the right side. The morphology of the Circle of Willis could not be correlated with either sex or Body Index.

Adult↗

PubMedDate not supplied

Development of the human fetal lung in the pseudoglandular stage: scanning electron microscopic remarks.

The lung buds of 15 human fetuses from the 9th to the 14th week of i.u. life were examined by scanning electron microscopy (SEM). SEM allows to clearly evidentiate the branching pattern of the respiratory tree, the development of the vascular network, the differentiation of the layers in the bronchial wall and the maturation of the epithelium. Particularly, as concerns the epithelium, its pattern in the air conducting ways and in the respiratory zone appears to be different from the very start; the presence of vascular spaces and then of well-defined vessels can be already detected starting from the 9th week of development.

Epithelium↗

PubMedDate not supplied

Collateral circulation in distal occlusion of lower limb arteries: an anatomical study and statistical research in 40 elderly subjects by echo-color-Doppler method.

The collateral circles and their hemodynamic significance in distal lower limb arterial occlusion have been described in an elderly population. Overall 40 subjects (20 men and 20 women; age range 66-83) with symptomatic lower limb arteriopathy (Fontaine's stage II) have been studied combing Contrast Angiography and Color Doppler Echography of the lower limb arterial district. In our population, the results showed that the tibialis arteries were the vessels most often involved in arterial occlusion (posterior tibialis a., 15 cases = 37.5%, posterior tibialis a., 12 cases = 30%), followed by the peroneal a. (8 cases = 20%) and by the popliteal a. (5 cases, 12.5%). In the occlusion of the popliteal artery the collateral circle was mainly established through the deep femoral a., the great anastomotic a., the recurrent posterior tibialis a., and from the articular supero-lateral a. In the occlusion of the anterior tibialis artery the collateral circulation was ensured through the collateral posterior tibialis as. and through the collateral perineal as. In the occlusion of the posterior tibialis a., the collateral circle was established through the great anastomotic a., through the branchers of the arterial circle of the ankle and from the perforating plantar as. (anterior tibial a.). Finally, in the occlusion of the peroneal a., the collateral circulation was only represented by branches of the arterial circle of the ankle. The hemodynamic compromission, measured by the Windsor Index, was the highest for popliteal occlusions (mean IW = 34.3%). Occlusions of the anterior tibialis a. (mean IW. = 35.48%), of the peroneal a. (mean IW = 44.71%), and of the posterior tibialis a. (mean IW = 55.44%) showed progressively lower hemodynamic compromission. Gender differences in hemodynamic significance at each level of occlusion were not significant.

Aged↗