Biomedical subjects

P Pène

Publications and source records attributed to P Pène.

At least 19 recordsLinked to original sources

PubMed1998

[Aids and insurance].

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Acquired Immunodeficiency Syndrome↗

PubMed1995

[Introduction to the session on the subject: physical activities and health].

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Adolescent↗

PubMed1991

[The synthesis of the epidemiology and treatment of malaria of the pregnant woman and the infant in subsaharan Africa].

This article summarizes informations regarding epidemiology, prophylaxis and treatment of Plasmodium falciparum malaria in pregnant women and children in subsaharian Africa. The authors recommend a regular antimalarial chemoprophylaxis using chloroquine and proguanil for pregnant women and particularly for primigravidae as they constitute a group at risk and considering the consequential effects on foetus. Precautions such as bed nets to avoid bites by infected mosquitoes are important. Chloroquine is the drug of choice for treatment in areas where P. falciparum remains sensitive. When chloroquine resistance exists or in cases of severe malariae, quinine must be used.

Africa↗

PubMed1991

[Short treatment of hepatic amebiasis by tinidazole. Apropos of 10 cases].

Ten cases of hepatic amoebiasis are notified in Bamako during 14 months among hospitalized adults. The diagnosis has aimed from clinical signs, specific antibodies seen through hemagglutination and echography. These patients are treated by tinidazole: 2 g/day in unique dose during 3-9 days. The duration of treatment depends on clinical evolution. In any cases the recovery is obtained within subsequent range from 1 to 9 months. This leading is compared with other treatments proposed in the literature. The briefness of treatment, its quick efficacy and the absence of secondary effects have helped to reduce the duration of stay in hospital and its cost. A short recovery by tinidazole is proposed as tentative treatment against hepatic amoebiasis in rural area's medicine.

Adolescent↗

PubMed1990

[Lessons of the socioeconomic structure of a cohort of 50 drug addicts infected with HIV and followed up over a year].

Fifty drug addicts, users of intravenous heroin and infected by HIV, with an average age of 28 years, were followed for a period of one year. The purpose was to analyze, as precisely as possible, the medical and social cost of their illness as a function of the stage of the infection to which they belonged. The costs vary significantly according to the age and sex of the patients, and are higher in those patients with stage IV (confirmed clinical AIDS) than with stage II and stage III HIV infection. Although the population of drug addicts infected by HIV is likely to stabilize, the medical and social cost of caring for HIV-infected drug addicts is very heavy, and can be estimated at about 4 to 5 billion french francs by year.

Adult↗

PubMed1989

[Imported falciparum malaria in Marseilles hospitals in 1987. Apropos of 104 cases].

Patients were composed of 85 adults and 19 children; 70 were European, 23 Comorian; malaria was contracted by 9 patients in French Guyana, 60 in Africa, 23 in Comoro Islands; prophylaxis was correct for 45 patients (nearly all of the cases with chloroquine) when the first symptoms occurred. Every case of malaria appeared during the month following their return from an endemic area. Fever was often moderate or intermittent, altered by prophylaxis and previous treatments. Some patients had a clinical profile of "visceral evolutive malaria" and 3 a cerebral malaria. The most frequent biologic alteration was thrombopenia (40 times under 100,000/microliters). No relation between parasites density and clinical profile has been identified. The sensitivity of the strains for antimalarial drugs has been studied 35 times: 28 strains were chloroquine resistant, 3 have a decreased sensitivity for quinine. Most of the resistant strains came from Central Africa. Two patients died.

Adolescent↗

PubMed1989

[Current clinical aspects and role of parasitic density in the manifestations of falciparum malaria].

56 patients carriers of Plasmodium falciparum were observed throughout 1987: 47 males and 9 females of a mean age of 32. The following clinical aspects were observed: Falciparum malaria: 35 cases, malaria with a low parasitaemia (less than 1,000 HPM): 5 cases, tropical splenomegaly syndrome: 3 cases, isolated bi- or tricytopenia: 10 cases, cerebral malaria: 1 case, asymptomatic carriers: 2 cases. Statistically speaking, no significant correlation was observed between parasitaemia and the following clinical and biological symptoms: fever, splenomegaly, Hb level, platelet count. However, we noted a level of parasitaemia higher in the acute forms of malaria (Falciparum malaria and cerebral malaria) than in the non typical forms (chronic visceral malaria, haematological disorders). All asymptomatic carriers, who represent "malaria infection", presented a low parasitaemia (less than 1,000 HPM).

Adolescent↗

PubMed1989

[Resistant falciparum malaria at the F. Houphouet-Boigny hospital in Marseilles in 1985-1986-1987].

Chemoresistant P. falciparum malaria emerged in South Sahara Africa during 1978 and is now more than half of the imported malaria in F. Houphouet-Boigny Hospital in Marseilles (France), consequently the annual number of malaria cases has doubled as compared to the previous years. In our study of 47 chemoresistant malaria cases, collected in 1985-1986-1987, mostly contracted in French-speaking Africa, residents and travellers were both equally affected. Curative treatment was quinine IV for severe malaria (34%), sulfadoxine-pyrimethamine (46.8%), and mefloquine (51%).

Adult↗

PubMed1988