p53 mutations in BRCA1-associated familial breast cancer.
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BRCA1 Protein↗
Biomedical subjects
P Osin
Publications and source records attributed to P Osin.
Hemangioendothelioma of the temporal bone in a child.
Hemangioendothelioma is a vascular tumor of endothelial cell origin. It may involve bone or soft tissues and can behave like a benign or a malignant tumor. In the literature there are several case reports on the involvement of the head and neck region, but only three cases of temporal bone involvement, all of them in adults. A 3-year-old child, complaining of left retro-auricular swelling and tenderness, was found to be suffering from hemangioendothelioma of the temporal bone. Doppler ultrasound and CT scan showed a highly vascular mass with bone destruction. Wide surgical excision was recommended, but rejected by the parents, nor did they agree to treatment with alpha-interferon. The child did not return for any further treatment.
Child, Preschool↗
Phyllodes tumors of the breast analyzed by comparative genomic hybridization and association of increased 1q copy number with stromal overgrowth and recurrence.
Phyllodes tumors are rare neoplasms of the breast. Although they contain both epithelial and stromal components they are considered to be stromally derived lesions. The chromosomal copy number changes were determined in 19 well characterized samples from 18 patients using comparative genomic hybridization. Most chromosomes were involved and generally the gains and losses were similar to those found in breast cancer with the exception that the phyllodes tumors showed no evidence of genomic amplification. The one recurrent sample analyzed had the same imbalances as the original tumor. Frequent changes were gain of 1q (7/18) and loss of 3p (6/18), followed by gain of 7q (4/18) and loss of 6q (4/18) and 3q (3/18). Gain of 1q material was significantly associated with histologically defined stromal overgrowth (P = 0.011). In addition, all the cases with gain of 1q material, without 1p gain, had a clinical history of recurrence. Only one case without 1q gain had a recurrence and this had loss of the X chromosome as the sole abnormality. Increased copy number of 1q material in the phyllodes tumors studied, in one case restricted to 1q24-32, was associated with recurrence (P = 0.00365) and might therefore be considered as an indicator of local aggressiveness requiring more radical treatment.
Adult↗
Metastatic adenocarcinoma in a thyroid colloid nodule: a rare presentation of colon cancer.
Colorectal cancer can remain asymptomatic for years. Frequently symptoms develop insidiously and may often remain unnoticed for long periods, even in the presence of disseminated disease. We herein report an unusual case of a patient with carcinoma of the sigmoid colon and multiple liver metastases. The diagnosis was established only after the patient was operated on for a large colloid nodule, a single microscopic metastatic focus being noticed in the histologic sections. The differential diagnosis compared with the columnar type of papillary carcinoma is discussed.
Adenocarcinoma↗
Fibrosarcoma of the thyroid in a man exposed to fallout from the Chernobyl accident.
Since the Chernobyl accident in April 1986, a dramatic increase in the incidence of thyroid carcinoma has been described, especially in children. A case of sarcoma of the thyroid in a man exposed to the Chernobyl fallout is presented. Sarcoma of the thyroid is a rare finding. The present patient lived in a region that is known to be one of the most exposed to Chernobyl fallout. The case suggests a high probability of a relationship between the sarcoma of the thyroid and the exposure to radiation.
Aged↗