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Biomedical subjects

P O Mack

Publications and source records attributed to P O Mack.

21 records · Page 2Linked to original sources

Benign retroperitoneal neurilemmoma--a case report.

Retroperitoneal neurilemmomas are the rarest of all retroperitoneal tumours. A rare case of a very large benign retroperitoneal neurilemmoma is presented. Pre-operative diagnosis of these tumours is difficult and the majority are asymptomatic. They are usually detected as an abdominal mass on routine examination as in this case. Despite severe displacement and distortion of the inferior vena cava in this patient, there were no clinical abnormalities detected. The predominantly cystic nature of the tumour was well demonstrated by ultrasound and CT scan examination but the true nature of the tumour could not be diagnosed. It is very rare for these tumours to be malignant and recurrence after surgical excision is rare.

Angiography↗

A simple method for in-vitro studies of cancer tissue metabolism.

A simple laboratory method of investigating the metabolism of malignant tissues has been devised for liver cancer. The apparatus consists of a standard glass scintillation vial with an inner glass well suspended within it from a rubber lined cap. 14C-labelled glucose metabolised by the tumour tissue in the inner well into 14CO2 will be trapped by alkali in the outer vial, and the radioactivity quantified by liquid scintillation counting. The counts obtained will give a measure of the rate of tissue glucose oxidation. Application of this method to an animal liver tumour model has shown that the tumour tissue has a glucose oxidation rate of 2.8 times that of the host liver. The method is simple and versatile, can be adapted to various types of tissues, and may have potential clinical applications.

Animals↗

DNA-binding compounds--synthesis and intercalating properties of a peptide-diamino diacridine.

A novel diacridine has been prepared in which two acridines are linked by a flexible peptide chain composed of gamma-aminobutyric acid, tyrosine, lysine and glycine. Synthesis of N-[9-acridinyl)-4-aminobutanoyl-tyrosyl-lysyl-lysyl-glycyl)-N'-(9- acridinyl)-1, 3-diaminopropane (VII) was achieved in 8% overall yield by a solution phase stepwise procedure. This compound binds to DNA by intercalation of both chromophores with at least a 140-fold enhancement of affinity compared to 9-aminoacridine.

Acridines↗