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Biomedical subjects

P O Davies

Publications and source records attributed to P O Davies.

7 recordsLinked to original sources
PubMed1998

The role of effective diagnosis for the control of gonorrhoea in high prevalence populations.

Gonorrhoea in the UK is now a highly focal problem that is localized to certain inner city areas where it presents a significant public health concern. However, the majority of men and a proportion of women infested with Neisseria gonorrhoeae do not experience symptoms of sufficient intensity to prompt them to seek medical advice and the current strategy of treating symptomatic individuals in specialist clinics with subsequent tracing of sexual partners is therefore failing to control the spread of infection in these areas. One method for addressing this problem would be the extension of effective diagnostic services into the clinical environments most likely to be accessed by these high-risk individuals. This paper reviews the scientific literature examining the various methodologies available for the identification of N. gonorrhoeae and assesses their suitability for the diagnosis of gonorrhoea in these alternative clinical settings.

DNA Probes↗
PubMed1991

Sequence of the t complex Tcp-10at gene and examination of the Tcp-10t gene family.

Transmission ratio distortion (TRD) is a property of complete t haplotypes which results in the preferential transmission of the t haplotype chromosome from heterozygous t/+ males to the majority of the offspring. A candidate gene for one of the primary genetic elements in TRD, the t complex responder locus has recently been suggested to be Tcp-10bt. There are multiple, functional Tcp-10t genes, but genetic data suggest the presence of the Tcp-10at gene alone is compatible with normal transmission ratios. Here we present the complete sequence and genomic structure of the Tcp-10at gene which is compared with sequence data from a number of cDNAs and genomic subclones representing all active Tcp-10t family genes. A detailed table of all sequence variants discovered in the course of our investigation is presented, and we have clarified the extent of 5' untranslated alternative splicing patterns exhibited by this gene family. A 60 base pair (bp) in-frame deletion from the 5' end of exon 3 of the Tcp-10at gene is also presented and compared with the equivalent region of Tcp-10bt and Tcp-10ct. A search of the University of Edinburgh database has revealed a significant homology between the Tcp-10bt open reading frame and several cytosolic filament proteins. Interestingly, the region of homology is involved in the deletion from the Tcp-10at gene.

Alleles↗