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Biomedical subjects

P Noel

Publications and source records attributed to P Noel.

At least 55 records · Page 3Linked to original sources
PubMed1984

Acute extrapyramidal dysfunction after domperidone administration. Report of a case.

The authors relate the observation of a 3-month-old boy who showed acute neurological dysfunction of the extrapyramidal system secondary to the administration of domperidone, a new anti-emetic drug. This drug was first believed not to provoke neurological dysfunction. Yet, this and three other published cases document the possibility of adverse neurological reactions due to domperidone administration.

Acute Disease↗
PubMed1982

Comparative immunohistochemical localization of fibronectin and actin in human breast tumor cells in vivo and in vitro.

The presence and distribution of fibronectin and actin in breast fibroadenoma cells have been investigated in frozen sections and primocultures of the same samples, by means of indirect immunofluorescence techniques. In the tissue cells, epithelial cells were negative whereas myoepithelial cells were positive with the two antibodies. Moreover, fibronectin was mainly distributed in basal lamina of ducts and ductules whereas actin appeared to label stroma cells. In primocultures obtained from the same samples of fibroadenomas, the labelled patterns of fibronectin and actin were not really distinguishable between cells; the two protein distributions were quite usual. Our data on human breast fibroadenoma cells are in agreement with the concepts of cellular adaptation or selection in culture and emphasize the difficulty in correlating results of "in vitro" and "in vivo" studies.

Actins↗
PubMed1981

[Senescence and melancholia (author's transl)].

This communication is an attempt to define, from a dynamic point of view, the specificity of the connection between depression and senescence. This aspect concerns primarily the subject's relation to his own death, the corporal nature of death being linked in a concurrent and irreducible way, with the unconscious reality of the "immortality phantasm". From a clinical observation, it is possible to show how depressive themes are images of death, in which way melancholia appears as the permanently manifest expression of the constantly deferred mourning. Involution is perceived no longer in terms of deficit but as the moment when death is substituted for the lost object, when the body becomes auto-destructive and reactivates through its betrayal all the previous experiences of mourning and separation.

Aged↗
PubMed1980

Non-traumatic clostridial myositis: an unusual feature of brain death.

In a case of brain death, a Clostridium sordellii and Escherichia coli septicaemia--of probable gastrointestinal origin--developed and was associated with a diffuse clostridial myositis. Factors responsible for the initiation and development of this unusual clostridial infection are discussed.

Adolescent↗
PubMed1980

[Effect of sample storage conditions and treatment on "free nitrite" in meat products].

The aim of the work presented here is to study the effect of different factors on the amount of "free" nitrite in meat products. Two kinds of factors are involved: --factors modifying the amount of "free" nitrite in the product; --factors modifying the amount of nitrite determined as "free". The former are mainly depending on the storage conditions of the products, for instance: low pH, light exposure, high temperature, increase the nitrite losses. The latter are depending on the analysis methodology. A strong physical treatment of the samples, a high temperature during extraction, a long time of extraction, the repetition of the extraction, increase the amount of nitrite determined as "free" by releasing a part of the bound fraction. So, it is very important, for the significance of results in "free" nitrite determination, to know very precisely storage and treatment conditions of the samples.

Animals↗
PubMed1979

HLA-D--related (DRw) antigens in juvenile diabetes mellitus.

We studied the distribution of HLA-D--related (DRw) antigens in 40 patients with juvenile diabetes mellitus (JDM) and 79 matched controls. We found that DRw2 was significantly decreased in the JDM group, suggesting a protective effect of the antigen and that the decrease observed in B7 was secondary. HLA-DRw3 and HLA-DRw4 were increased in the diabetic group, and, as with B8/B15, these two antigen predisposed to the disease additively. The susceptibility for JDM was found to be more strongly related to HLA-DRw3 that to B8. On the other hand, B15 rather than DRw4 showed the stronger association with JDM. Moreover, we found that this second diabetogenic gene is associated primarily with B15 and only secondarily with Cw3, which is in linkage disequilibrium with B15. This study further emphasizes the immunogenetic heterogeneity of JDM.

Diabetes Mellitus, Type 1↗
PubMed1977

Regional cerebral blood flow in children. A rheoencephalographic study of the modifications induced by reading.

Cerebral impedance changes (F changes) indicating cerebral blood flow were studied in 17 children aged 6-11 years and in 10 normal adults. At rest, large values were found in children, who never exhibited the 'hyperfrontality' pattern of the adults. Reading induced an F increase in both the dominant and non-dominant hemispheres, in contrast with a larger increase in the dominant hemisphere in adults. A spatial test was designed in adults which triggered a larger increase in the non-dominant hemisphere.

Adult↗