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Biomedical subjects

P Noble

Publications and source records attributed to P Noble.

18 recordsLinked to original sources
PubMed1991

Infants and atropine: a dangerous mixture.

Colic in infants is a common but short-lived problem. Many different theories and treatment for this distressing ailment have been tried over the years, yet the definitive cure remains elusive. Although the risks associated with the use of atropine and its derivatives are well known, they are still prescribed by some in the management of colic. We report a case of serious side effects from the treatment of colic with an atropine containing mixture, in which an error in preparation was identified. In view of the potential for serious toxicity resulting from either inappropriate prescription, preparation or administration, alternative methods of treatment should be employed.

Atropine↗
PubMed1989

Violence by psychiatric in-patients.

A register of violence incidents showed a progressive increase in in-patient violence from 1976 to 1984, followed by a slight decline to 1987. The case notes of all 137 in-patients committing assaults during 1982 were analysed and compared with those of matched controls. Violence was often repetitive. The most common victims were nurses and then patients. The violent patients were more likely to be schizophrenic, deluded and hallucinated, and to have been repeatedly admitted. The violent and control groups had similar backgrounds, and both showed high levels of social isolation and unemployment. Violence tended to be repetitive, and the violent patients were usually identifiable from previous aggressive and disturbed behaviour. There was a high proportion of Afro-Caribbean patients who tended to be younger, more psychotic, and more seriously violent. Afro-Caribbeans were particularly likely to be detained compulsorily and treated in a locked ward.

Adolescent↗
PubMed1987

Testing for HIV.

Explore the source record for details and available documents.

HIV Seropositivity↗
PubMed1987

Effects of 5 alpha-dihydrocorticosterone on evoked responses and long-term potentiation.

The effect of a Ring A-reduced metabolite of corticosterone, 5 alpha-dihydrocorticosterone (DHB) on long-term potentiation (LTP) in the dentate gyrus (DG) of the rat were studied in barbiturate-anaesthetised animals. It was observed that DHB significantly impairs the development of LTP, more particularly the population spike (PS) component of the evoked potential (EP) to perforant path (PP) stimulation. Nutralipid, an inert control solvent of the steroid, did not affect LTP development. We argue that both, membrane and intracellular effects of DHB, are involved in the mechanisms responsible for DHB blocking of LTP.

Adrenalectomy↗
PubMed1986

Inflation pressure effect on performance of air-filled wheelchair cushions.

Air-filled wheelchair cushions are frequently used in the prevention of pressure sores. Their effectiveness in reducing interface pressures and in redistributing body weight (BW) appears dependent on their internal inflation pressure. This pilot study examines and defines this relationship. Interface pressures were measured with the TIPE (Texas Interface Pressure Evaluator) system for 14 subjects while sitting on each of three commercially available air-filled wheelchair cushions. This relationship between interface pressure and internal pressure was then determined for each of the three body-build categories. In each category the interface pressure displayed a higher degree of sensitivity to underinflation than to overinflation. A high correlation found between BW and internal air pressure (IAP), may be useful in the design of a customized pressure indicator system. The study documents the influence of IAP on seating pressure and supports the need for further research in the development of an indicator system that alerts users to under- or overinflation of the cushion.

Air↗
PubMed1971

Drug taking in adolescent girls: factors associated with the progression to narcotic use.

A follow-up study of girls in a London remand home during the years 1966-8 showed that 20.6% of those taking non-narcotic drugs on admission, but only 1% of non-drug-taking control admissions, had used narcotics by June 1970. Narcotic use on admission and progression to narcotic use were associated with frequent drug taking, marked involvement in a drug milieu, and a high incidence of personal morbidity. Adolescents who use illicit drugs and have a history of court appearances for any reason are particularly vulnerable to subsequent narcotic usage and other forms of serious drug abuse.

Adolescent↗