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Biomedical subjects

P Niederer

Publications and source records attributed to P Niederer.

62 records · Page 4Linked to original sources
PubMed1980

A viscoelastic model for use in predicting arterial pulse waves.

In nonlinear mathematical models of the arterial circulation, the viscoelasticity of the vessel walls has generally been neglected or only taken into account in a highly approximate manner. A new method is proposed to simulate the nonlinear viscoelastic properties of the wall material with the aid of a convolution integral of the creep function and the pressure history. With this simulation it is possible to properly describe the measured characteristics of arterial viscoelasticity. Moreover, it is utilized in a mathematical model of arterial pulse propagation to study the influence of the internal wall friction on the shape, amplitude and mean value of pressure and flow pulses. The corresponding predictions are in much better agreement with in-vivo measurements, especially for the distal part of the circulation, than those obtained without viscoelasticity.

Animals↗
PubMedDate not supplied

Analysis of near-infrared spectroscopy and indocyanine green dye dilution with Monte Carlo simulation of light propagation in the adult brain.

Near-infrared spectroscopy (NIRS) combined with indocyanine green (ICG) dilution is applied externally on the head to determine the cerebral hemodynamics of neurointensive care patients. We applied Monte Carlo simulation for the analysis of a number of problems associated with this method. First, the contamination of the optical density (OD) signal due to the extracerebral tissue was assessed. Second, the measured OD signal depends essentially on the relative blood content (with respect to its absorption) in the various transilluminated tissues. To take this into account, we weighted the calculated densities of the photon distribution under baseline conditions within the different tissues with the changes and aberration of the relative blood volumes that are typically observed under healthy and pathologic conditions. Third, in case of NIRS ICG dye dilution, an ICG bolus replaces part of the blood such that a transient change of absorption in the brain tissues occurs that can be recorded in the OD signal. Our results indicate that for an exchange fraction of Delta=30% of the relative blood volume within the intracerebral tissue, the OD signal is determined from 64 to 74% by the gray matter and between 8 to 16% by the white matter maximally for a distance of d=4.5 cm.

Adult↗
PubMedDate not supplied

Passive autofocusing for digital endoscopic imaging systems.

An autofocus is a desirable feature of an endoscope, because it relieves the user from performing a task which can be automated and thereby prevents unnecessary interruptions in the work to be performed. Autofocusing is in general best achieved by an active system, i.e., on the basis of a distance measurement. Yet, in handheld medical endoscopes such a method is unsuited because of the added weight associated with the necessary electromechanical components. Autofocusing should rather be performed passively, furthermore, in applications which are particularly critical with respect to safety, e.g., in the eye, a stable and reliable operation in real time and without interruption is necessary. Passive autofocus strategies applied to date and known to the authors lead however to algorithms which are either too slow for a real time implementation and/or are influenced by the structure of the object which is to be brought into focus. Accordingly, a new autofocus procedure has been developed which exhibits a stable and reliable operation in real time under all circumstances of interest. It is based on the squared differences of the intensity of adjacent points in both dimensions of a plane image (Square Plane Sum Modulus Difference, SPSMD) and as such particularly suitable for digital camera systems and real-time needs (typically, 30 evaluations per second on an image of 1024 x 1024 pixels). The SPSMD criterion is more sensitive, has a larger SNR than other focus criteria known to the authors and exhibits in particular no secondary extrema which could adversely affect proper focusing. As it includes intensity differences in both (perpendicular) directions in the image plane, it is essentially independent of image structures.

Endoscopes↗