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Biomedical subjects

P Newman

Publications and source records attributed to P Newman.

At least 91 records · Page 5Linked to original sources
PubMed1978

Toxicity manifestations following intravenous Corynebacterium parvum administration to patients with ovarian and cervical carcinoma.

Manifestations of clinical toxicity were evaluated following 341 courses of intravenous Corynebacterium parvum adjuvant immunotherapy in patients with ovarian and cervical carcinoma. Most patients exhibited symptoms of minor toxicity, which decreased in intensity as subsequent courses of therapy were administered. Temperature elevations to 38.5 degrees C. were the most objectively measured signs of toxicity but temperature elevations greater than 38.5 degrees C. occurred following only 20.5 per cent of the infusions. Blood pressure alterations were not a serious problem and no serious central nervous system or renal toxicity was noted. The minor side effects should not preclude the use of C. parvum as an immunopotentiating agent if it is shown to be beneficial in the treatment of human malignant disease.

Blood Pressure↗
PubMed1978

Assessment of rheumatoid inflammation in the knee joint. A reappraisal.

Subjective pain score, clinical assessment, 99m technetium joint uptake, infrared thermography, and thermistor skin temperature measurements were evaluated and compared in patients with rheumatoid knee treated with intra-articular hydrocortisone. In 11 patients with definite and classical rheumatoid arthritis, 10 of whom had unilateral knee involvement, the affected knee joints were assessed by the above techniques before and at intervals after treatment of up to 14 days. The anti-inflammatory property of the steroid therapy was shown by all the assessment parameters, values having decreased significantly from the pretreatment values. However, the only parameter still showing a statistically significant decrease on the 14th post-treatment day was 99mTc joint uptake. Correlations were obtained between the two clinical measurements assessed by a physician i.e. pain score and index of joint inflammation. Both of these also correlated with the 99mTc joint uptake but not with skin temperature measurements. Using the clinical assessments as a yardstick, 99mTc joint uptake seemed to provide a useful index of changes in disease activity in the group as a whole. However, skin temperature measurements by infrared thermography and by the thermistor were of considerably less value.

Arthritis, Rheumatoid↗
PubMed1978

Tuberculous brain abscess.

Brain abscess is probably the least common manifestation of tuberculous infection of the central nervous system. Some authors have made a rigid distinction between tuberculous brain abscess and variants of cerebral tuberculoma. Such a distinction is not supported by our own case of tuberculous brain abscess, or by review of similar, recently reported cases.

Brain Abscess↗
PubMed1976

Woodpeckers and head injury.

The woodpecker is an experiment in Nature, a model for the investigation of mechanisms of basic importance for head injury and its prevention. A preliminary anatomical study of the woodpecker's head suggests that it may be fruitful to explore impact protective systems which are radically different from those in common use.

Animals↗
PubMed1971

Nasal acquisition of Staphylococcus aureus in partly divided wards.

The spread of coagulase-positive staphylococci has been studied in a modern hospital in which most of the patients were nursed in 4-bed rooms separated from a common corridor only by low dividing walls. Acquisition of new nasal strains from patients in other bedrooms was nearly as easy as from patients in the neighbouring beds. There was no indication that subdivision of this type hindered the spread of nasal strains as compared with open wards of the ;Nightingale' pattern.

Air Microbiology↗
PubMedDate not supplied

Assessment of myocardial perfusion during cold stress using thallium-201 scintigraphy in diabetic patients with abnormal changes in left ventricular function during cold stress.

Eleven type-I (insulin-dependent) diabetic patients with abnormal changes in left ventricular function in response to cold stress (CS) were investigated to try and determine the cause of these abnormal responses. Resting M-mode echocardiography demonstrated that all 11 patients had normal left ventricular dimensions and wall motion, thereby excluding overt cardiomyopathy. Thallium-201 scintigraphy was used to assess myocardial perfusion during CS and eight patients were found to have perfusion defects during stress which persisted in four. It is possible that CS unmasks evidence of myocardial ischemia but it is also possible that the abnormal responses to CS reflect altered vasomotor reactivity in the diabetic patient, producing coronary spasm. Left ventricular function may be influenced by many factors in diabetes and an abnormal CS test may not necessarily indicate structural disease. Such tests, however, may help in the further understanding of the pathophysiology of heart disease in diabetes.

Adult↗
PubMedDate not supplied

How to manage your boss.

Explore the source record for details and available documents.

Administrative Personnel↗
PubMedDate not supplied

Gunshot wound to the foot: early management and pathophysiology of projectile wounds.

The authors present a case study of gunshot wound and discuss the rationale for therapy after hemostasis is established. Treatment consists of debridement of necrotic tissue, immobilization to prevent further movement of the bullet, and immediate antibiotic therapy to prevent bacterial invasion. They emphasize the necessity of understanding the pathomechanics and pathophysiology of ballistic injuries and advocate removal of the bullet, when possible, to relieve discomfort, to prevent anemia and renal failure, and to avoid the danger of lead intoxication.

Adult↗