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Biomedical subjects

P Neven

Publications and source records attributed to P Neven.

75 records · Page 5Linked to original sources
PubMedDate not supplied

BM 144: an original thromboxane A2 receptor antagonist derived from torasemide.

Torasemide, a new sulfonylurea high ceiling loop diuretic, has been demonstrated to induce a concentration dependent relaxation of canine coronary precontracted with thromboxane A2 (TXA2). With the aim to develop more potent TXA2 receptor antagonists, we investigated a series of torasemide derivatives. This pharmacomodulation led to the discovery of a sulfonyl-cyanoguanidine (BM 144) which presents the same pharmacological profile as sulotroban, a TXA2 receptor antagonist used as reference.

Humans↗
PubMedDate not supplied

Effects of nimesulide and indometacin on COX-1 and COX-2: a comparative study.

Evidence of the existence of two forms of cyclooxygenases and the clinical relevance of COX-2 inhibition led to the development of COX-2 selective NSAIDs. In order to evaluate this selectivity, we have developed and validated an enzymatic method. The precision and reproducibility of the assay were determined and COX-2 selectivity examined using nimesulide and indometacin.

Cyclooxygenase 1↗