Search PubMed⌕ Search

Biomedical subjects

P Netter

Publications and source records attributed to P Netter.

At least 325 records · Page 18Linked to original sources
PubMed1980

[Bismuth osteoarthropathies. Concern with bone bismuth dosage].

Impulsion polarography with anodic redissolution, a very sensitive means of dosage that is easy to repeat and more selective than atomic absorption, makes it possible to affirm the presence of bismuth in the bones after oral or parenteral treatment in 6 patients, 5 of whom suffered from osteoarthropathies that could be linked, given their nature, to the treatment administered, though this could not be proven. The presence of bismuth in the bone tissue of these patients must be considered in the physiopathological discussion of their osteoarthropathies, especially since none of them showed signs of encephalopathies.

Adult↗
PubMed1980

[Multifactorial disturbances and compensatory phenomena in the materno-fetal unit (author's transl)].

Clinical and laboratory data as well as morphological placenta findings of approximately 7 000 pregnancies recorded in a program of the German Research Association (DFG): "Course of pregnancy and development of the newborn" are examined for statistically significant correlations. It could be shown that there is a correlation between haemoglobin-level during pregnancy and maturation of the placenta villi. Low maternal haemoglobin frequently coexists with complete villous maturation. The same interaction is true for placental size or weight and maternal haemoglobin. Small placentas show a--sometimes precocious--complete villous maturation, whereas placentas with greater volume still possess immature villi at term. This finding is different in combination with placental infarcts, which lead to a complete maturation of persistent villi, especially, if the maternal haemoglobin shows low values at the same time. The combination of the factors: low maternal haemoglobin and small placental insertion area or insufficient placental maturation and low maternal haemoglobin lead with statistical significance to a high frequency of babies with low birth weight in relation to the duration of pregnancy. This is not the case, if one of the two factors involved shows favorable characteristics (morphological findings in the placenta with good functional aspects--maturity, insertion area--and low haemoglobin or high haemoglobin in combination with favorable placenta findings). Summing up the results demonstrate that interactions between single factors of the materno-fetal transfer-system constitute a basic developmental principle.

Female↗
PubMed1979

[Ankylosing spondylitis in monozygous twins. Study of HLA complex (author's transl)].

A study of HLA complex (HLA A, B, C, DRw, Bf, chiddo) in monozygous twins suffering from ankylosing spondylitis with different clinical courses. All the markers studied were identified. The results would tend to suggest that hereditary factors are not alone responsible in the course of ankylosing spondylitis. Furthermore, they are not the sole causative factor of the disease since the literature contains reports of discordant pairs of twins.

Adolescent↗
PubMed1979

Pharmacokinetics of salicylates in elderly.

In order to study changes in the pharmacokinetics of salicylates in old people, we used two groups of inpatients without hepatic or renal impairment: the first comprised 15 patients more than 65 years old, mean age 77 years; the second, 7 patients of mean age 21 years. Each patient was given 1 g of acetylsalicylic acid orally in the morning while fasting. Blood samples were subsequently taken after 30, 60 and 90 min and 2, 3, 4, 6, 8, 10, and 24 h. Fluorimetric assay results were analyzed kinetically with a mathematical model corresponding to a single diffusion compartment model. The results showed only a slight increase in the absorption half-time in old subjects, and a marked increase in elimination half-time (3.71 and 2.38 h in old and young subjects, respectively; t = 2.33: p less than 0.05) and in the volume of distribution (5.51 and 3.83 liters respectively; t = 3.20: p less than 0.1). On the other hand, bioavailability varied little, as did metabolic clearance. This study confirms that intestinal absorption of this drug is not much impaired in old people, while hepatic and/or renal elimination functions are changed. This finding agrees with results found for aminopyrine, antipyrine, and digoxin.

Adult↗
PubMed1979

Measurement of bismuth in bone by pulse polarography with anodic stripping voltammetry. Application to two cases of arthropathy.

Pulse polarography with anodic stripping has shown the presence of very high levels (2 005 microgram/kg and 6 760 microgram/kg) of bismuth in bone of two patients treated with bismuth, one parenterally and the other orally. The presence of high levels of bismuth in bone of these patients must be considered in the etiology of their athropathies. Pulse polarography with anodic stripping now permits very precise measurement of bismuth impregnating bones.

Aged↗
PubMed1979

[Study of cellular elements in synovial fluid in scanning electron microscopy].

Scanning electron microscopy allows a tridimensional morphological study of the cellular elements of the pathological human synovial fluid. The cells are grouped into two populations: macrophage cells and round cells, whose differentiation is more difficult: polynuclears, lymphocytes and synovial cells. The combination of scanning electron microscopy and X-ray diffraction makes it possible to describe and indentify crystals of sodium urate and of triclinical, dehydrated calcium pyrophosphate.

Arthritis, Rheumatoid↗
PubMed1978

[Effect of diphenylhydantoin administered during gestation and lactation on the motor development and cerebellar histology of the young rat].

Rattus norvegicus females were treated by diphenylhydantoin (D.P.H.), all along pregnancy and lactation. 4 groups were constituted: a 100 mg DPH/kg/day group, a 50 mg DPH/kg/day group; a placebo group (treated with pure water), and control group. D.P.H. was given twice a day by a gastric tube. The cerebellar Purkinje cells studied through light microscopy and transmission electron microscopy in young rats (25 days old) showed no visible alteration. 2 motorcoordination tests were applied to the young rats, during their 2nd and 3rd weeks of post-natal life. Young rats of DPH 100, DPH 50 and placebo groups showed a backwardness relatively to control. This backwardness may be attributed to the maternal forced feeding stress, but not to a specific action of the DPH.

Animals↗
PubMed1978

[HLA DRw in ankylosing spondylitis].

The association of ankylosing spondylarthritis with the B locus and more specifically with the B 27 antigen, is the closet known for any illness. The absence of linkage with the DRw antigens studied during this project, in 50 patients, can give rise to the hypothesis that spondylarthritis is associated with determinants situated on the B lymphocytes, linked to the HLA-B locus.

Adult↗
PubMed1978

[Scintigraphic characteristics of coxopathies: etiologic importance].

Morphological and quantitative studies of the uptake of diphosphonates labelled with technetium 99m were done on 179 pathological hips : 106 aseptic osteonecroses of the femoral head, including 20 at an early stage, 11 algodystrophias (transitory osteoporoses of the hip), 20 coxarthrosis, 16 cases of Paget's disease, 12 isolated malignant lesions of the femoral neck. The location, extent and intensity of the uptake are very variable and depend not only on the etiology of the lesions but also on their stage of evolution. Bone scintigraphy provides, for numerous pathological hips, pieces of information which complete the results of the clinical, radiological and biological study, with which it should always be compared. It can shed light on the etiologic diagnosis of a painful hip at the beginning of its evolution, before the appearance of rare x-ray signs, thanks to certain very precise characteristics of the labelling. This is the case for algdystrophias, osteonecroses, coxitis and strain fractures of the femoral neck.

Femur Head Necrosis↗
PubMed1978

[Experimental psychophysiological studies on the effects of fenetylline and mefenorex].

16 male subjects were tested 1--7 h after the application of either 40 mg of the anorectic mefenorex, 50 mg of the stimulant fenetylline or a placebo by a battery of psychophysiological and psychological methods. Two problems of basic psychological interest were investigated: 1. covariation of appetite and central stimulation; 2. indicators of activation assessed by different parameters. The results concerning the first problem were inconclusive. The results with respect to the second show that pharmacological substances may cause dissociation of different indicators of activation.

Amphetamines↗
PubMed1977

[Scanning electron microscopy study of the synovial membrane in rheumatoid arthritis].

A comparative study under the scanning electron microscope of rheumatoid synovial membranes, 5 arthrosic synovial membranes, one tuberculous membrane, and 3 normal synovial membranes showed the pathological changes in the synovial membrane due to rheumatoid arthritis: Inflammatory aspect of the synovial fringes, surrounded by turgid and proliferative villous processes. Granular appearance of the endo-articular surface like a "pebble beach". Dome-shaped synoviocyte layer, standing out well above the subjacent intimal layer, associated with small round cells, also with a raised margin, covering most of the endo-articular surface. Plasma membrane of the superficial synovial cells, covered with numerous and various differentiations and abundant microvillous processes. Reticular deposits or layers, covering the apical poles of the synoviocytes.

Arthritis, Rheumatoid↗
PubMed1977

[Interpretation of and indications for bone scintiscans].

The interpretatiton of a bone radioisotope scan requires perfect knowledge of normal skeletal appearances, shadows outside the bones and the various methods of expression of bony lesions: generally hyperfixations but sometimes isofixations or even hypofixations. A bone scan permits one to make an overall assessment of multiple bony lesions, determine the extent of a lesion, detect bony complications of a disease or treatment and seek the bony origin of a pain.

Bone Diseases↗
PubMed1977

[Gamma heavy chain disease associated with rheumatoid arthritis. Spontaneous disappearance of the pathologic protein].

The authors report the chance discovery in a man aged 53 years with serum positive rheumatoid arthritis, of gamma 3 heavy chain disease. The originality of this case depended on the absence of any detectable lymphoid proliferation and on the transient character of the pathological protein. Only the course after a long follow up will determine whether there is no incipient lymphoid proliferation and whether the heavy chain disease has disappeared permanently.

Arthritis, Rheumatoid↗
PubMed1977

[Interactions of salicylates and other nonsteroid anti-inflammatory agents].

The salicylates are frequently associated in every day treatment with other non-steroid anti-inflammatory drugs, which justifies a study of their interactions. Animal pharmacodynamics, although interesting, is of little practical interest. Pharmacokinetic research seems to indicate that aspirin reduces the bio-availability of other non steroid anti-inflammatory drugs, which has not yet been confirmed clinically. It is still premature to conclude, but the already established facts suggest the continuation of such studies.

Animals↗
PubMed1977

[The placebo effect (author's transl)].

Placebos are liable to affect most diseases, physiologically autonomic and emotional functions and types of performance and also to produce side effects. Types of reactions to placebos are highly dependent on suggestion. Tranquilizer properties are registered more frequently than those of stimulants, and placebos are taken for active drugs more often than vice versa. Type of application, personality of the therapist and intensity of the stress situation may potentiate or diminish the effects of placebos in a specific manner. Constancy of time and situation as a condition for the identification of a placebo reactor is demonstrable to a limited extent only.

Dosage Forms↗