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Biomedical subjects

P Netter

Publications and source records attributed to P Netter.

At least 235 records · Page 13Linked to original sources
PubMed1987

[Configuration frequency analysis. XXIII. Types and syndromes of a higher order].

Configural Frequency analysis (CFA) is a method for the detection of significantly high or low frequencies in multivariate contingency tables. As a criterion for the comparisons. CFA uses expected frequencies from log-linear models which reflect assumptions on the association structure of the variables under study. The present paper extends models of CFA such that triplet associations or even higher order associations can be considered. Examples use empirical data from research on depression in children. Results show the existence of higher order types.

Child↗
PubMed1987

Psychological aspects of catecholamine response patterns to pain and mental stress in essential hypertensive patients and controls.

In an experimental study on hypertensive and healthy subjects, the role of anxiety, sex, and disease for the response of plasma epinephrine (E) and norepinephrine (NE) to pain (venipuncture) and mental stress (word alliteration) was investigated. Pain elicited higher E values than mental stress in healthy subjects and higher NE responses in both sexes, but hypertensive subjects did not respond by generally higher catecholamine values than normotensive subjects did. They were, instead, characterized by decreases of NE upon mental stress. Trait anxiety, as measured by questionnaire scores, was associated with higher E values in healthy and hypertensive subjects but mainly after physical pain and not after mental stress. NE responses to pain were significantly lower in anxious than in nonanxious hypertensive subjects, and the opposite held true for normotensive subjects. Thus, high E/low NE response emerged as an indicator of trait anxiety, as well as state anxiety. Correlations between experienced aversiveness and catecholamine levels identified NE as a hormone of successful coping on which hypertensive subjects seem to rely more than normotensive subjects do when trying to counteract their particular threat of physical pain.

Adult↗
PubMed1986

[Familial articular chondrocalcinosis].

Articular chondrocalcinosis is a well-defined radiological entity with or without clinical manifestations. A familial form was described by Sitaj and Zitnan in 1957. Attention has mostly been paid to chondrocalcinosis associated with metabolic diseases and to "sporadic" chondrocalcinosis, usually due to ageing of the joint. Familial chondrocalcinosis, of which more and more cases are reported, is increasingly under study and is used as a model for pathogenic research. It already appears that familial chondrocalcinosis, of dominant autosomal transmission, is a new metabolic disease.

Calcium Pyrophosphate↗
PubMed1986

Association and transfer functions for analysis of drug binding to proteins.

A global association function is proposed that characterizes the apparent overall equilibrium of drug protein binding. It is defined as a function of the total drug concentration and may be directly calculated from each experimental result. The binding transfer function represents the relative rates of change in the bound and free concentrations from the total concentration. Two applications are presented: one is an investigation of the effect of temperature on binding of salicylic acid to proteins in plasma; and the other is a comparison of the phenomenon in two different biological fluids (protein binding of sodium salicylate in plasma and in synovial fluid).

Blood Proteins↗
PubMed1986

Expression of the mitochondrial split gene coding for cytochrome oxidase subunit I in S. cerevisiae: RNA splicing pathway.

We have studied the splicing pathway leading to the synthesis of cytochrome oxidase subunit I (COX I) mRNA, by analysing the transcription pattern of several oxi3- splicing deficient mutants located in the first four introns of the gene. The four introns contain long open reading frames (ORFs) in phase with the upstream exons. All the mutations block the excision of the mutated intervening sequence (IVS) from the pre-mRNA, and accumulate characteristic novel polypeptides of sizes which could correspond to the translation products of the intron's ORF. Most of the mutations do not affect the splicing of the following intervening sequences; only in the case of mutations in the aI1 intron is a polar effect observed on the splicing of the second intron, aI2. Our results indicate that the splicing of these two intervening sequences which both belong to the class II of introns described by Michel et al. (1982), is controlled by the activity of the maturases encoded by their respective ORFs and that the translation of the aI2 maturase depends on the previous excision of aI1 IVS. (Moreover, the aI1 maturase, which accumulates in some mutants, can efficiently splice aI2 IVS when the translation of the latter's proper maturase cannot occur).

Electron Transport Complex IV↗
PubMed1986

Estimation by high-performance liquid chromatography of ketoprofen in plasma. Application to the study of its protein binding.

A method of estimation by high-performance liquid chromatography of ketoprofen in plasma is proposed. This method is rapid, simple, and very sensitive: it allows concentrations of 2 ng/ml to be determined. The internal standard is (benzoyl-4-phenyl)-2-butyric acid. The drug is extracted from a biological fluid in ether, which is then evaporated; the residue is taken up in chromatographic eluant (acetonitrile/phosphate buffer pH 7), analysed by reverse-phase chromatography and detected by spectrophotometry at 256 nm. In spite of the very strong protein binding of this drug, this method allowed the determination of its free concentration in plasma.

Carrier Proteins↗
PubMed1986

A case of amiodarone-induced hyperthyroidism and hepatitis: results of clinical laboratory and histological tests.

We report a case of amiodarone-induced hepatitis accompanied by hyperthyroidism in which estimations of amiodarone in blood and in the liver and histological examinations were performed at the start and end of a 3-month interval. Our observation demonstrates the persistence in the liver of amiodarone and its principal metabolite for 3 months after the drug was withdrawn. There was no correlation between the persistence of the drug, the elevation of enzyme levels, and the extent of histological damage in the liver.

Amiodarone↗
PubMed1985

Diffusion of intramuscular ketoprofen into the cerebrospinal fluid.

Serum and cerebrospinal fluid (CSF) concentrations of ketoprofen have been measured in 36 patients hospitalised for sciatica. Diagnostic lumbar puncture was done 15 min to 13 h after a single 100 mg intramuscular dose of ketoprofen. Serum and CSF were sampled at the same time. Free serum concentrations were determined by equilibrium dialysis. Total and free concentrations were assayed by a highly sensitive and specific HPLC method. Ketoprofen rapidly crossed the blood-brain barrier and was detected in CSF 15 min after its administration. The rapid diffusion can be explained by the high lipid solubility of the drug. The CSF level was in equilibrium with the free serum concentration from the second to the 13th hours.

Adult↗
PubMed1985

Salicylate kinetics in old age.

Salicylate kinetics were determined in 28 subjects 25 to 92 years old who received single, oral doses of sodium salicylate (1 gm/1.73 m2). The serum AUCinfinity of total salicylate did not correlate with age. There was a weak positive correlation between the AUCinfinity of free (unbound) drug and age, but there was no apparent difference between the AUCinfinity values of the 15 women and 13 men. Seven of the 16 subjects greater than 70 years of age cleared salicylate at about the same rate as the younger subjects. A comparison of these seven subjects with the nine greater than 70 years old who were slow eliminators of salicylate revealed that the latter group consisted of more bedridden patients and that these patients had somewhat lower serum albumin concentrations, but they did not differ from the more rapid eliminators with respect to serum creatinine or urea nitrogen levels, SGOT, average age, female/male ratio, and average body weight. The serum protein binding of salicylate decreased with increasing age, apparently due mainly to decreasing serum albumin concentrations.

Administration, Oral↗