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Biomedical subjects

P Nath

Publications and source records attributed to P Nath.

At least 37 records · Page 2Linked to original sources
PubMed1994

Tumours of the male urogenital tract: a clinicopathologic study.

The present communication deals with the study of 388 tumours of the male urogenital tract diagnosed histopathologically during the period of 1984 to 1990. Of these 12 (3.09%) were benign and the rest 376 (96.91%) malignant. The incidence of malignant growths of male urogenital tract was 8.71% of all the malignancies or 14.19% of all cancers in males. Renal tumours constituted 10.64% of all the malignant tumours of male urogenital tract or 1.51% of all the male cancers. Morphological variants were renal cell carcinoma (37.5%), Wilms' tumour (47.5%), transitional cell carcinoma (7.5%), papillary cystic adenocarcinoma (3.5%), leiomyosarcoma (2.5%), metastatic from thyroid (2.5%). The mean age of the cases for renal cell carcinoma was 50.3 years and for Wilms' tumour 3.5 years. Urinary bladder cancer comprised 29.52% of all the malignancies of male urogenital tract or 4.19% of all malignant growths in males. The average age of the patients was 53.9 years. Transitional cell carcinoma was the commonest type of tumour (91.9%). Primary malignant tumours of the testis constituted 0.95% of all the malignancies, 1.55% of all male cancers, 10.9% of all malignancies of male urogenital tract or 18.3% of all the malignant growths of male genital tract. The mean age of the patients was 40.6 years. Seminoma was the commonest -46.34% of all the testicular tumours. The incidence of prostatic cancer was 1.81% of all cancers, 2.95% of all malignancies in males or 20.74% of all malignancies of male urogenital tract or 34.82% of malignancies of male genital tract.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1992

Demonstration of two forms of vitellogenin in serum of estradiol-17 beta-treated Indian major carp, Labeo rohita.

Vitellogenin (Vg) synthesis was induced in the male and non-vitellogenic female Rohu, the Indian major carp, by estradiol-17 beta(E2) where effect was more in female. A crude preparation of Vg was isolated in the second peak after gel filtration on Ultrogel AcA 34 from the sera of vitellogenic female Rohu and E2-treated male and female Rohu. Estimation of alkali-labile phosphorus was shown to be used as an index of Vg. Native-PAGE analysis has revealed the presence of two forms of Vg (Vg1: 430,000 dalton and Vg2:240,000 dalton) in Vg fraction obtained after gel filtration as well as in the sera of E2-treated male and female Rohu. Immunological cross-reaction studies between antiserum to yolk protein and Vg fractions as well as the sera from E2-treated male and female Rohu further indicates the presence of two precipitin lines (not clearly visible as the two lines fused to form a thick line) suggesting the occurrence of two forms of Vg in the Rohu.

Animals↗
PubMed1991

Vertical Banded Gastroplasty-Gastric Bypass: preliminary report.

Vertical banded gastroplasty-gastric bypass is a surgical technique combining the advantages of the vertical banded gastroplasty with those of gastric bypass. The procedure was performed on 148 morbidly obese individuals: 83% were female, and 17% were male. Ages ranged from 15 to 64 years, with a mean age of 35. Mean percentage weight was 215% of ideal. The vertical banded gastroplasty is constructed by creating a 10 cc vertical pouch along the lesser curvature with a 5.5 cm supporting band. The pouch is fashioned in a way that the lower portion is free and mobile. This free segment of stomach is anastomosed by triangulation to a Roux-en-Y loop of jejunum, which is brought up in a retrocolic, retrogastric fashion. With 100% follow-up in the 19 patients who have reached 1 year, average excess weight loss has been substantial. There was one early postoperative complication requiring surgery. Two patients required late revisional operations. Vertical banded gastroplasty-gastric bypass is a relatively simple procedure to perform and has a low rate of complications. Gastric bypass in combination with a small banded pouch along the lesser curvature should result in substantial and permanent weight loss.

Journal Article↗
PubMed1989

Purification and properties of pituitary gonadotropic hormone from Indian teleosts: freshwater murrel (Channa punctatus) and carp (Catla catla).

Gonadotropic hormone (GtH) from the pituitaries of two widely different Indian teleosts, a freshwater murrel and a carp, was purified by solvent fractionation, Sephadex G-100 gel filtration, affinity chromatography on concanavalin A-Sepharose (Con A-Sepharose), and immunoaffinity chromatography. Elution profile from gel filtration showed three peaks in both cases, peak I and II were clearly separated in murrel but not in carp. Peak II demonstrated strong GtH activity in both murrel and carp but this activity could also be detected in peak I and III of carp. TSH activity was restricted to peak I in murrel and was distributed in all three peaks in carp. Chromatography on Con A-Sepharose was useful in harvesting carp glycoprotein hormones, but gave no advantage in murrel. A pure homogenous GtH from murrel and carp could be obtained by using immunoaffinity chromatography. Polyacrylamide gel electrophoresis of murrel and carp GtH showed a single discrete band. Determination of molecular weight (MW) by Sephadex G-100 gel filtration indicated that murrel and carp GtH were 42,000 and 40,000 Da, respectively. SDS-polyacrylamide gel electrophoresis of murrel and carp GtH revealed two dissimilar subunits, alpha and beta. MW of murrel and carp alpha-subunits were 18,000 and 16,000 while those of beta were 27,000 and 26,000 Da, respectively. Comparison of electrophoretic patterns of murrel and carp GtH alpha and beta with ovine LH subunits reveal distinct teleostean GtH subunits.

Animals↗
PubMed1989

Ultrastructural reappraisal of endometrial glandular changes in women wearing Cu-T200 device for longer duration.

The present communication deals with the effects of Copper-T200 Sq mm intrauterine device on the endometrial glands in the women using it for a longer duration i.e. up 8 years. The ultrastructural changes in the lining endometrial glands were studied during both non-ovulatory and ovulatory phases of the menstrual cycle. The ultrastructural studies demonstrated significant progressive changes in the lining endothelial cells of endometrial glands. The findings showed marked accumulation of glycogen in the cells in secretory phase of the endometrial cycle. Ultrastructural changes in glandular lining cells were more pronounced in women using Cu-IUCD for 4-8 years having distorted morphology with disrupted cell organelles, swollen mitochondria, irregular pattern of microvilli, deposition of electron dense material on cell surface and narrowing of glandular lumen.

Adult↗