[Lupus erythematosus panniculitis].
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Adipose Tissue↗
Biomedical subjects
P Nagler
Publications and source records attributed to P Nagler.
The concentration of bupivacaine in fetal organs during obstetrical epidural analgesia.
The concentration of bupivacaine in organs of non-viable human fetuses after obstetrical epidural analgesia in customary doses was investigated. The concentrations were determined with a gas chromatograph. The material consisted of a fetus who died following termination in the 24th week of pregnancy three minutes after birth without spontaneous respiration. The other fetus was born maturely in the 40th pregnancy week with anencephaly who lived 20 minutes following initial spontaneous respiration. Most noteworthy were the increased concentrations in the liver indicating the important metabolic function of the liver for the metabolism of bupivacaine in the fetus. Further a very high pulmonary concentration was found in the mature fetus. Even though blood gases analysis were not performed we conclude that: the lung is the best perfused organ after birth and onset of spontaneous respiration because of the closure of the ductus arteriosus; because of the increasing agonal respiratory acidosis, bupivacaine accumulates in the lung, the organ from which the acidosis originates. Also, the ionized form the bupivacaine is unable to leave the intracellular space. For the clinical use of epidural analgesia during delivery, these results constitute an important indication for avoiding fetal acidosis before and during the action of such analgesia. This mandates strict and continuous fetal monitoring. Our results in agreement with other authors show that during fetal acidosis and simultaneous administration of bupivacaine the fetal distress may be potentiated by an accelerated transfer of the anesthetic agent into the fetal placental space. Under normal conditions one may assume that this technique of analgesia has a positive effect on the fetus because of the improved placental perfusion.(ABSTRACT TRUNCATED AT 250 WORDS)
Anesthesia, Epidural↗
On possible involvement of adrenocorticoids in chicken spleen development.
The possible effects of glucocorticoids on spleen development were assessed by the determination of changes in mean organ weight and histology in chicken (Gallus gallus) embryos at stages 44 and 45 of Hamburger and Hamilton on days 19.5 and 20 of incubation (N = 10--13). After the administration of 1 to 6 mg of metopirone (an 11-beta-hydroxylase inhibitor) the numbers of white-pulp periarterial nests and red-pulp granulocytes decreased. The changes associated with metopirone treatment were less evident after the addition of corticosterone (20 and 200 microgram). After adding corticosterone alone (200 microgram), the white-pulp nests appeared larger than in control. Mean body and spleen weights or spleen-body weight ratios did not change much after treatment. Possibly glucocorticoids normally direct these aspects of spleen histogenesis in chicken embryos.
Animals↗
[Bacterial sacroiliitis].
We saw two cases of infectious sacroiliitis in young patients. The multi-various clinical symptoms, the predispositions, as well as the alteration of laboratory analyses are described. Further, we discuss problems of early diagnosis, diagnostic measures like x-ray, sonography, bone-scan, computerized tomography scan, magnetic resonance imaging, and their particular significance. Computerized tomography scan of iliosacral joints determined the further therapeutic procedure. In both cases, we prescribed cephalosporin-antibiotic cefotaxime-sodium.
Abscess↗