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Biomedical subjects

P Murray

Publications and source records attributed to P Murray.

At least 145 records · Page 8Linked to original sources
PubMed1976

A study of the morphological changes in the small intestine of the spontaneously diabetic Chinese hamster.

Several morphological changes were observed microscopically in the small intestine of some diabetic Chinese hamsters. Although some alterations lacked statistical significance due to variation, most diabetics displayed a greater incidence and severity compared with nondiabetic controls. The following structural deviations were seen in the small intestines of some diabetics: increased surface area, elevated number of goblet cells per villus, decreased muscle thickness with connective tissue infiltration, reduced number of Auerbach's plexuses, lymphocyte aggregations accompanied by blunted villi, blood vascular lesions and deformed villi due to excessive loss of epithelial cells.

Animals↗
PubMed1975

An endogenous oncornavirus of guinea pigs: its expression in leukemic cells.

Guinea pigs do not have any known infectious oncornaviruses. We have recently activated an endogenous oncornavirus (GPV) from cultured guinea pig cells after bromodeoxyuridine riboside (BUdR) treatment. GPV is noninfectious for guinea pig cells and is inducible from any guinea pig cell in culture. Although the morphogenesis of the activated virus is unique, it has the morphology and density (1.16 g/ml) of type C oncornaviruses. It contains an oncornavirus specific reverse transcriptase and a high molecular weight RNA (70S) which dissociates into 36S following denaturation. GPV contains 5 major protein components (mol. wt. 95,000 to 16,000 daltons), 2 of which are glycoproteins. The viral genome which remains repressed in normal cells is expressed in leukemic guinea pig cells. These leukemic cells contain particles which have the morphological and biochemical characteristics of BUdR activated endogenous viruses. Unlike the cells transformed by infectious oncornaviruses, the leukemic cells contain the same amount of virus specific DNA present in normal cells.

Animals↗
PubMedDate not supplied

Hip arthroplasty, changing trends in a national tertiary referral centre.

BACKGROUND: Despite changes in techniques and management, little has been published comparing hip replacement surgery over a three-decade time span. AIMS: To document change in the practice of hip arthroplasty in a large elective orthopaedic centre. METHODS: A retrospective analysis of 100 patients in 1979 and in 1999 comparing demographics, surgical approaches, blood loss, transfusion requirements, morbidity and length of stay. RESULTS: In 1999, males predominated, spinal anaesthesia had largely superceded general anaesthesia, the anterolateral approach had replaced the trans-trochanteric approach, osteoarthritis remained the main aetiology and the Charnley prosthesis remained the implant of choice. Average blood loss was higher in 1999 compared to 1979 (1,378 vs 1,225 ml) but all patients in 1979 were transfused with an average of 2.8 units while in 1999 one-third of patients were transfused with an average of 1.6 units (p<0.0001). Length of stay had fallen from 30.5 days in 1979 to 16.2 days in 1999 (p<0.0001). Thromboembolic complications fell from 13% to 2% (p=0.0083). CONCLUSION: The incidence of deep venous thrombosis (DVT), pulmonary embolus (PE) and length of hospital stay has fallen. Blood loss had changed little but fewer patients receive blood transfusion.

Aged↗
PubMedDate not supplied

BCL2 expression predicts survival in patients receiving synchronous chemoradiotherapy in advanced transitional cell carcinoma of the bladder.

It has been reported previously that BCL2 expression predicted a poor response to neo adjuvant chemotherapy but had no prognostic significance in patients receiving radiotherapy alone. We therefore investigated its role in patients receiving synchronous chemoradiotherapy as treatment for advanced bladder cancer. We examined expression of BCL2 and P53 by immunohistochemical analysis using archival tissue samples taken from patients included in the phase I/II trial of synchronous chemoradiotherapy for advanced transitional cell carcinoma (TCC) of the bladder. Data were collected on 24 patients who presented with invasive bladder cancer to the Queen Elizabeth Hospital between March 1998 and January 2001. Eleven patients had died at the time of analysis, with median follow-up of 34 months for the 13 surviving patients. Median survival for patients with strongly BCL2 positive tumours was 12.8 months while, for BCL2 weak or negative patients, the median is yet to be reached (p=0.03). The hazard ratio was 3.37 in favour of BCL2 negative tumours having longer survival. This study shows that over-expression of BCL2 in patients receiving synchronous chemoradiotherapy is an independent indicator of poor survival in muscle invasive TCC of the bladder.

Adult↗