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Biomedical subjects

P Morrison

Publications and source records attributed to P Morrison.

At least 109 records · Page 6Linked to original sources
PubMed1982

Effect of cimetidine on the absorption and efficacy of orally administered furosemide.

In six normal subjects who received single oral doses of 400 mg cimetidine and 40 mg furosemide, the area under the furosemide plasma concentration-time curve was increased in two subjects by less than 50%, in two by 59% and 75%, and remained unchanged in two: overall the mean increase of approximately one-third achieved statistical significance. This increase was not accompanied by any significant effects on other pharmacokinetic parameters or urine volume, sodium or potassium excretion during the 8 h subsequent to drug administration. Furosemide produced no effects on cimetidine pharmacokinetics. In another group of subjects, administration of 1.0 g cimetidine/day in divided doses before dosing with 40 mg furosemide produced no significant effects on furosemide plasma levels or in its effects on urinary water and electrolyte excretion.

Absorption↗
PubMed1982

A study of repeated administration of fenbufen in patients with chronic rheumatic disorders and renal impairment.

Male and female patients suffering from rheumatoid arthritis with normal renal function or with renal impairment were treated in hospital with 300 mg of fenbufen 8 hourly for fourteen days. Concentrations of fenbufen and its principal metabolites were measured by high pressure liquid chromatography on days 0, 7, 10 and 14 and also four days after discontinuation of the drug. Renal impairment does not produce cumulation of either fenbufen or its major metabolites in the plasma. The metabolite profile of the drug was similar to that observed in patients with normal renal function.

Adult↗
PubMed1977

Plasma lipid levels and lipoprotein ratios in ten rodent species.

Cholesterol, triglyceride, and non-esterified fatty acid (NEFA) levels and lipoprotein electrophoretic patterns in blood plasma of ten species of wild rodents are compared with those of the laboratory mouse and man under standard conditions. 1. Average plasma lipid levels for the mouse and man appear in the middle of the wide ranges of 0.6-1.8 g/l. for cholesterol, 0.4 to 2.4 g/l. for triglyceride and 0.32-0.68 m-equiv/l. for NEFA found in these rodents suggesting species may vary in their ability to utilize these lipids. 2. Some universal relationship between levels of cholesterol and triglyceride, but not with NEFA, are suggested by a comparison between average levels in these 12 species. 3. Lack of correlation between the typical four component human lipoprotein electrophoretic pattern with any of the uniquely different patterns of rodents indicate using this method it is not feasible to compare the blood lipid transport system amongst species.

Animals↗
PubMed1976

Computer simulation of leukemia therapy: combined pharmacokinetics, intracellular enzyme kinetics, and cell kinetics of the treatment of L1210 leukemia by cytosine arabinoside.

An integrated mathematic computer-based model of the pharmacokinetics, intracellular enzyme kinetics, and cell kinetics of the treatment of L1210 leukemia by cytosine arabinoside (ara-C) is described. The compartment model of Bischoff and Dedrick is extended to the intracellular level by inclusion of equations describing the phosphorylation, dephosphorylation, and deamination of ara-C with enzymatic feedback control. The activities of kinase, deaminase, and phosphatase are explicitly included in the models and are estimated from relevant data. Cell proliferation is described by a continuous-flow mathematic model in which cellular maturation and cell-to-cell variability in maturation rates are key variables. Cell proliferation is related to intracellular biochemistry through mathematic expressions which relate cell lethality and progression delay to the time course of intracellular ara-CTP. In vitro and in vivo experiments performed in a number of laboratories are compared by simulation. The most sensitive parameters in dose-response and cell-survival simulations are deoxycytidine kinase activity, ara-CTP half-life, renal clearance of ara-C, and cell-kinetic parameters for proliferation and cell killing. Progression delay is vital to the realistic simulation of divided-dose schedules. By comparative simulation we have identified areas of uncertainty which can be classified by a few additional measurements. The applications of simulations combining pharmacokinetic, biochemical, and cell-kinetic data in vitro and in vivo are discussed, exploring consistency among different measurements, and relating experimental protocols to clinical treatment.

Animals↗
PubMed1976

Breeding and reproduction of fifteen wild rodents maintained as laboratory colonies.

Data on reproduction and production were presented for laboratory colonies of Microtus pennsylvanicus tananaensis, M oeconomus macfarlani, M o operarius, M mirurus, M abbreviatus, Lemmus lemmus, L sibiricus trimucronatus, Dicrostonyx stevensoni, Clethrionomys rutilus, Peromyscus maniculatus borealis, P m bairdii, Baiomys taylori, Calomys ducilla, C callosus, Acomys cahirinus. Litter size varied from 2.0 in A cahirinus to 5.5 in C callosus. Infant (neonatal) and juvenile losses through the end of the first month ranged from 9% in C callosus to 45% in M o operarius. Young successfully weaned per female ranged from 3.4 in L sibericus to 15.2 in P m bairdii. The number of young weaned per female per month, which may be the most useful measure of production, ranged from 0.6 in A cahirinus to 2.6 in C ducilla. The most common 21-da interval between litters confirms postpartum estrus and mating, and a 21-da gestation in most cricetids.

Animals↗