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Biomedical subjects

P Morris

Publications and source records attributed to P Morris.

At least 199 records · Page 11Linked to original sources
PubMed1979

Breath-by-breath halothane monitoring during anaesthesia. A study in children.

The use of a halothane meter in routine paediatric anaesthesia with controlled ventilation is described. The results demonstrate the accuracy achieved in the control of the alveolar halothane concentration. Measurement of the alveolar halothane concentration revealed responses to surgical stimulation otherwise obscured by neuromuscular blockade, and this may indicate insufficient depth of anaesthesia.

Adolescent↗
PubMed1978

A rapid-response u.v. halothane meter.

The design and performance characteristics of an instrument for monitoring halothane concentrations which operates on the principle of the absorption of u.v. light are described. The innovation is that the entire exhaled breath passes through the sample cell, enabling the breath-by-breath halothane concentration to be measured accurately and instantaneously. Stablized power supplies, solid-state circuitry and filtering make the instrument stable and selective. A valve prevents rebreathing of gas exposed previously to u.v. light in the sample cell. Inspired and end-tidal concentrations are displayed digitally and an analog output is available also. Zero and gain drift were negligible after an initial settling period, and interference from other respiratory gases was not detectable. The monitor is suitable for use during anaesthesia for adults and children.

Adult↗
PubMed1978

Evaluation of renal preservation using the isolated perfused rat kidney. Ischaemic damage and the effects of inosine.

An isolated perfused rat kidney has been used to determine the response to prolonged warm ischaemia and to examine renal preservation procedures. All measurements of function declined to near zero after 90 min of warm ischaemia. Measurement of total sodium reabsorption (TNa) was the most sensitive indicator of renal damage. Inosine was without effect on subsequent renal function after 60 or 90 min of warm ischaemia, or after 24 hr of cold ischaemia. Surface cooling or hypertonic citrate solution, in the cold or at 37 degrees C, significantly improved renal function, and their use in clinical renal preservation rather than that of inosine was supported by the present results.

Adenosine Triphosphate↗
PubMed1977

Cytologic evaluation of breast fluid in the detection of breast disease.

The availability and cell content of aspirated breast fluid from 1,706 women were evaluated to determine the usefulness of breast fluid cytology as an indicator of breast disease. A newly developed aspirator was used to obtain cells adequate for diagnosis from approximately 50% of the women tested. Fluids were most readily available from women between the ages of 30 and 50 years. Although abnormal cytologies were observed in all age groups, the relative proportion of abnormal specimens as well as the degree of abnormality increased as a function of age. More women over 40 years of age with a high risk of breast cancer had cells classified in the more abnormal categories than did women in the normal risk group. To localize otherwise occult lesions, contrast ductography was performed on all women with very abnormal ductal cells. Women with atypical hyperplastic cytologies most commonly had benign and premalignant breast disease at subsequent biopsy. Of 27 women with fluids classified as suspected carcinomas 18 (66%) had small carcinomas. These observations strongly suggested that the presence of atypical cells in aspirated breast fluids has important clinical application for early detection of breast cancer. One limitation of cytology was that the technique rarely detected carcinomas greater than 1 cm.

Adult↗
PubMed1977

Treatment of pneumatosis cystoides coli by oxygen inhalation.

Endotracheal intubation and intermittent positive pressure ventilation were used to overcome the difficulties of oxygen therapy for pneumatosis cystoides coli in a 9-year-old child with Down's syndrome and a congenital heart defect. As compared to previously reported cases, a shorter duration of treatment and a lower arterial oxygen tension proved successful.

Child↗
PubMed1976

Serological identification of Ia antigens: report of a British region Ia workshop.

In preparation for the 7th International Histocompatibility Workshop 13 laboratories in the British Region participated in a local workshop. One hundred and twenty-three sera which had been previously shown to have activity on either normal B cells, CLL cells or B cell lymphoid lines in the absence of HLA-A, B or C activity were exchanged between the laboratories. These sera were tested on a total of 212 B cells, 101 CLL cells, 76 T cells and 76 lymphoid cell lines. The data was collected and analyzed in Oxford. The analysis showed that six groups of sera could be distinguished. When these groups were compared with the D locus typing of some of the lymphoid lines which were derived from individuals used as MLC typing cells, they were seen to have significant associations with D locus antigens. The serological groups defined were therefore given numbers corresponding to the D locus numbers they associate with, i.e. UK1 is associated with DW1 and so on for UK2, 3, 4, 5 and 7. Comparison of typing techniques showed that long incubation both with antiserum and then with complement, 1 hour + 2 hours gave the best and most reproducible reactions on normal B cells. Residual anti-HLA-A, B or C activity in some of the sera even after platelet absorption showed the importance of adequate checking on T cells after absorption.

Antibody Specificity↗
PubMed1975

The management of popliteal aneurysms.

Twenty-three patients with 34 popliteal aneurysms were treated between 1963 and 1974. Nearly half of the aneurysms were the site of thrombosis when they first presented, and of these nearly half required a major amputation. Surgical treatment of aneurysms in which the popliteal artery was patent was satisfactory; the only failure occurred when a Dacron graft became occluded after eight years. A small group of patients was observed for an average of one year, during which time the thrombus in one aneurysm embolized and one aneurysm became occluded, necessitating an amputation. The results of this series suggest that the prognosis for a limb with popliteal aneurysm depends on the patency of the popliteal artery at the time of the initial presentation, and lends support to the belief that popliteal arteries with aneurysms are best reconstructed before the onset of a serious complication.

Adult↗