Search PubMed⌕ Search

Biomedical subjects

P Morgan

Publications and source records attributed to P Morgan.

At least 55 records · Page 3Linked to original sources
PubMed1998

Synthesis and structure-activity relationships of novel naphthalenic and bioisosteric related amidic derivatives as melatonin receptor ligands.

A previous paper reported the synthesis of melatonin receptor ligands. In order to complete the structure-activity relationships and to obtain antagonists to the melatonin receptor, a new series of naphthalenic analogues of melatonin have been synthesized. Modifications include deletion of the 7-methoxy group, replacement of the ethylene moiety, replacement of the amidic function by bioisosteres, and replacement of the naphthalenic nucleus by other bicyclic rings. Almost all the structural modifications lead to decreased affinity for the melatonin receptor. However, the N-n propyl urea derivative (27) is a very potent ligand at this receptor (pKi = 14.3). Most interestingly deletion of the methoxy group resulted in the first antagonist in this series. This molecule, compound 12, or N-[2-(1-naphthyl)-ethyl]cyclobutyl carboxamide has been selected for preclinical development.

Amides↗
PubMed1998

Mucous membrane pemphigoid: a dual circulating antibody response with IgG and IgA signifies a more severe and persistent disease.

Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease frequently associated with scarring of involved clinical sites. At present, therapeutic intervention in the form of immunomodulating or immunosuppressive agents is often reserved until the onset of significant inflammation and/or early cicatrization. We have therefore studied the clinical and immunopathological findings in 67 patients with MMP in order to try to establish a reliable prognostic indicator by which patients at high risk may be identified early in the disease. Inclusion criteria were a predominantly mucosal disease and the detection of IgG and/or C3 anti-basement membrane zone (BMZ) immunoreactants using immunofluorescence techniques. Patients were allocated to three disease subgroups on the basis of the modality and duration of therapeutic intervention required to achieve effective control of disease. In addition, at presentation and at each follow-up visit, a clinical score for severity of involved clinical sites was awarded and serum collected for indirect immunofluorescence (IIF). A dual circulating anti-basement membrane zone (anti-BMZ) antibody response with IgG and IgA was significantly associated with a more severe and persistent disease profile (P < 0.001). The odds ratios for requiring systemic therapy were: 11.6 among patients in whom there was a clinical score > or = 5 compared with a score < 5, and 31.3 and 66.9 among patients with IgG alone and both IgG and IgA, respectively, compared with negative IIF. The findings suggest that an assessment based upon a combination of site severity score and the presence of circulating IgG and IgA by IIF using 1 mol/L salt-split human skin substrate may be considered a useful prognostic indicator.

Adult↗
PubMed1997

A note on the use of the CEC L-33-A-93 test to predict the potential biodegradation of mineral oil based lubricants in soil.

The biodegradabilities of five unformulated mineral oils (brightstock, 150 SN base oil, white oil and two gas oils) were determined in the CEC L-33-A-93 test and during 20 weeks incubation in nutrient-supplemented soil microcosms. Biodegradation in both studies was measured as the loss of extractable hydrocarbon ('primary' biodegradation). There was a statistically significant (P < 0.01) rectilinear relationship between the extents of biodegradation in both test systems. The results indicate that the CEC method could be used as a relatively simple, quick and inexpensive test for assessing the potential biodegradation of mineral oil based lubricants in soil.

Biodegradation, Environmental↗
PubMed1997

UVB therapy: dermatology nursing considerations.

Each patient responds uniquely to phototherapy treatment. Not every patient can tolerate daily treatment. Different areas of the body require different amounts of light in order to clear. Precise documentation of erythema is important for both treatment and legal reasons. A negative response to UVB therapy can be from either ineffective treatment or an adverse reaction to UVB.

Dose-Response Relationship, Radiation↗
PubMed1997

Psoralen photochemotherapy.

Psoralens and sunlight have been used by the Egyptians and Indians for hundreds of years for treating vitiligo. The combination of oral psoralens and artificial ultraviolet A (PUVA) therapy was approved for managing severe psoriasis by the Food and Drug Administration in 1982. Since then, PUVA therapy has been an effective modality for treating many cutaneous conditions (psoriasis, atopic dermatitis, vitiligo, and mycosis fungoides). However, proper knowledge and administration of PUVA therapy are vital to treatment success and reducing side effects.

Education, Nursing, Continuing↗
PubMed1996

A readout magnet for prepolarized MRI.

Conventional MRI systems rely on large magnets to generate a field that is both strong and extremely uniform. This field is usually produced by a heavy permanent magnet or a cryogenically cooled superconductor. An alternative approach, called prepolarized MRI (PMRI), employs two separate fields produced by two different magnets. A strong and inhomogeneous magnetic field is used to polarize the sample. After polarization, a weak magnetic field is used for readout. These fields can be produced by two separate resistive electromagnets that cost significantly less than a single permanent or superconducting magnet. At Stanford, the authors are constructing a PMRI prototype scanner suitable for imaging human extremities roughly 20 cm in diameter. With this system the authors hope to demonstrate comparable image quality to MRI with reduced system cost. The authors' initial work on low-frequency reception indicates that it will be possible to obtain comparable image signal-to-noise ratio to an MRI scanner operating at the same polarizing field strength. To reduce the capital cost of the system, the authors use resistive electromagnets. Here the authors discuss the full development of the readout magnet including important design considerations, shimming, and field plots. These encouraging results are an important step toward evaluating the cost effectiveness of PMRI.

Cost-Benefit Analysis↗
PubMed1996

Safety and immunogenicity of Lyssavac Berna human diploid cell rabies vaccine in healthy adults.

A clinical trial testing the safety and immunogenicity of a newly developed human diploid cell rabies vaccine (Lyssavac-HDC) was conducted on subjects at three colleges of veterinary medicine in the United States. Lyssavac-HDC is a sterile lyophilized vaccine containing no antibiotics or preservatives and is administered intramuscularly as a 0.5 ml dose of vaccine containing at least 2.5 i.u. of rabies inactivated antigen per dose. Subjects were given either a three dose pre-exposure series (days 0, 7, and 28), followed by one booster dose of vaccine (day 360); or a five dose simulated post-exposure series of injections (days 0, 3, 7, 14, and 28). All subjects in the post-exposure and pre-exposure groups possessed adequate levels of rabies neutralizing antibody (> or = 5) when tested on day 14 and day 28, respectively. Subjects in the pre-exposure group demonstrated a vigorous anamnestic response after the administration of one booster dose of vaccine on day 360. The type and severity of local and systemic reactions observed were comparable to other primary cell culture rabies vaccines. Significantly, there were no type III hypersensitivity reactions reported in subjects previously immunized with Lyssavac-HDC after the administration of a booster dose of vaccine on day 360.

Adult↗
PubMed1996

Involving doctors in management. A survey of the management development career needs of selected doctors in NHS Wales.

Reports the results of a survey of 209 senior registrars and 269 consultants throughout Wales to identify the management development needs of doctors and ascertain their views of the value and utility of current management development course offerings in Wales. Finds that, currently, management development for doctors in Wales is unstructured and uncoordinated but, despite this, many doctors, especially senior registrars, appeared keen to increase their future involvement in management and held positive views regarding management and management development. The questionnaire also required doctors to rank order six managerial topics and their elements: financial, human resource, strategic, operational, service quality and self-management. Of these, self-management issues were rated highest and there was some congruity in the rankings of the six topics by senior registrars and the other three consultant categories. Overall, managing a budget, medical and clinical audit, negotiating skills and leadership skills were ranked highest for inclusion in management development while project management, quality circles and equal opportunities received the lowest ratings.

Attitude of Health Personnel↗
PubMed1996

Abatement of tropospheric ozone: effects of strategies to improve air quality on public health and other sectors.

The National Health and Medical Research Council's air quality goal for ozone in the troposphere (near the earth's surface) is 0.12 parts per million (ppm), averaged over one hour, similar to the United States standard, but less stringent than the guideline for Europe. We aimed to identify the environmental, economic and social changes that would be associated with changing the goal. Methods included literature review, economic assessments and group interviews. The group to benefit from lower exposures may include outdoor workers, school children and people not in regular day-time work indoors, because ozone is most prevalent during the daylight hours of the warmer months. A lower level could improve the yield of some crops. The causes and effects of tropospheric ozone are not appreciated except among groups with relevant commercial, industrial or scientific experience. However, the consultations identified frustration about the social problems caused by dependence on private motor vehicles. Short-term costs of compliance with a more stringent goal would fall principally on the users of transport. The value of the benefits was enough for many to support making the ozone goal more stringent, but those who required a demonstration of financial benefit (even including savings of health care costs) did not support any change to the goal. Based primarily on averted detriment to health, we recommend the more stringent level of 0.08 ppm (one-hour average) as the goal for the year 2005 in Australia and elsewhere. The addition of a goal with longer averaging time is also proposed.

Air Pollutants↗
PubMed1996

Basic principles of photobiology and photochemistry for nurse phototherapists and phototechnicians.

Phototherapy administration requires a team approach to be safe and effective. Implementing the treatment plan requires the knowledge, skills, and expertise of the entire health care team. Understanding the relationship between natural light, artificial light sources, administration of phototherapy, and the short and long-term consequences of the therapy can enhance the experience for the patient and provide an increase in employment satisfaction for the therapist.

Humans↗
PubMed1996

Phototherapy equipment.

Treating patients with phototherapy is like dosing patients with medication. The purpose of this continuing education article is to describe various phototherapy equipment and how to conduct safe and efficacious therapy.

Equipment Safety↗
PubMed1996

Staff responsibilities for phototherapy administration.

Caring for the phototherapy patient is a multifaceted role; however, the primary nursing responsibility is quality patient education. The opportunities to implement this responsibility are as endless as the disease itself.

Humans↗
PubMed1995

Metabolism of the genotoxicant 2-nitropropane to a nitric oxide species.

The mechanisms by which the paint constituent 2-nitropropane (2-NP) exerts genotoxicity and hepatocarcinogenicity are poorly understood. The hypothesis was tested that nitric oxide (NO) is a hepatic metabolic intermediate generated from 2-NP and/or its anionic tautomer propane 2-nitronate (P2N). Incubations of liver microsomes from phenobarbital-pretreated rats or mice with 2-NP or P2N gave spectra with Soret maxima at 448 nm which indicated the presence of a ferrous-NO complex. Levels of 3':5'-cyclic guanosine monophosphate (cGMP) and nitrite were measured by ELISA assay and HPLC, respectively, in freshly isolated mouse hepatocytes. Levels of cGMP generated within 3 h in cells by 2-NP, P2N (5 mM each) or the diethylamine/NO complex [Et2NNO(N==O)]Na (0.6 mM), an NO precursor, were 6, 15 and 34 times, respectively, those seen in control hepatocytes. Production of cGMP following treatment with 2-NP was linear with time of incubation; cGMP generation from P2N reached its peak already after 1 h. cGMP levels observed in incubates with 1-nitropropane and 2-deutero 2-nitropropane (5 mM), 2-NP isomers devoid of genotoxic properties, were significantly lower than those seen in the presence of 2-NP. Inclusion in the incubate of methylene blue, which inhibits NO-mediated reactions, decreased cGMP formation in hepatocytes with [Et2NNO(N==O)]Na, but increased it in cells with 2-NP or P2N. The production of nitrite from 2-NP, P2N or [Et2NNO(N==O)]Na mirrored cGMP formation. The results suggest that 2-NP and its nitronate generate an NO species in cells which may mediate, or contribute to, 2-NP genotoxicity.

Animals↗
PubMed1995

Spinal anaesthesia in obstetrics.

Spinal anaesthesia has been used since the 1800s but, due to a number of complications, the popularity of this technique has waxed and waned. In the 1950s, it was the most widely used method of anaesthesia and analgesia in obstetrics but it fell out of fashion with the arrival of the epidural technique which allowed a continuous method of delivering analgesia with relatively few complications. Hypotension and the high incidence of postdural puncture headaches were two reasons for the decline in the popularity of spinal anaesthesia in the young, otherwise healthy pregnant population. With the development of newer needles and bevel designs and methods whereby the incidence of hypotension can be minimized, spinal anaesthesia is making a reappearance in obstetrical anaesthesia spheres. The purpose of this article is to review the history, effects, technique, indications, contraindications and complications of this method of anesthesia as it applies to the obstetrical patient.

Anesthesia, Epidural↗