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Biomedical subjects

P Mora

Publications and source records attributed to P Mora.

At least 55 records · Page 3Linked to original sources
PubMed1995

No evidence for oncogenic mutations in the adrenocorticotropin receptor gene in human adrenocortical neoplasms.

The mechanism(s) of tumorigenesis for the majority of adrenocortical neoplasms remain unknown. G-Protein-coupled receptors were recently proposed as candidate protooncogenes. That activating mutations of this class of receptors might be important for tumor induction or progression of endocrine neoplasms was strengthened by the recent identification of such mutations in hyperfunctioning thyroid adenomas. To examine whether the ACTH receptor (ACTH-R) gene could be an oncogene in human adrenocortical tumors, we amplified by the polymerase chain reaction and directly sequenced the entire exon of the ACTH-R gene in 25 adrenocortical tumors (17 adenomas and 8 carcinomas) and 2 adrenocortical cancer cell lines. We found no missense point mutations or even silent polymorphisms in any of the tumors and cell lines studied. We conclude that activating mutations of the ACTH-R gene do not represent a frequent mechanism of human adrenocortical tumorigenesis.

Adolescent↗
PubMed1992

[Focal hepatic lesions. Their diagnosis by fine-needle (25 G) aspiration puncture].

151 patients with focal lesions of the liver underwent percutaneous fine-needle aspiration biopsy under ultrasonographic control. We used 25 G needles, the thinnest available. Aspiration biopsy was performed on malignant disease in 122 cases, and on benign disease in 29 cases. There were 3 false negatives diagnosis and 2 minor complications. The overall accuracy of the cytologic evaluations was 91.2%, with a sensitivity of 89.1% and specificity of 100%. Guided percutaneous fine-needle aspiration biopsy is recommended for a morphological diagnosis of focal liver lesions, because of its simplicity, safety and high degree of correct diagnosis.

Adult↗
PubMed1992

[Severe digestive hemorrhage of an unusual etiology. Visible isolated and bleeding esophageal vessels].

We describe two patients with massive upper gastrointestinal bleeding. The upper gastrointestinal endoscopy revealed jet haemorrhage in the distal portion of the esophagus, from a visible vessel, without esophageal mucosal damage. In both cases arteriography was performed, and did not show vascular malformations or fistulous points. The patients were successfully treated, one with endoscopic sclerosis and balloon tamponade, and the other with endoscopic sclerosis and transcatheter embolization through left gastric artery. For the time being we do not know the true importance of these findings, but we hope that other reports help us to understand the clinical and pathologic features of this vascular lesion, and the best therapeutic approach.

Adolescent↗
PubMed1991

[Portal hypertension secondary to an arterioportal fistula. Treatment by embolization].

We report a case of arterioportal fistula which was probably the result of percutaneous liver biopsy. Portal hypertension with hemorrhage by esophageal varices was the clinical presentation. We describe the features of the ultrasound, selective arteriography and Doppler ultrasound examination. The fistula was catheterized superselectively and successfully embolized with steel coils.

Adult↗
PubMed1989

[Macrolide-theophylline interaction. Experiences in pediatrics].

Subjects suffering from bronchial asthma being treated with theophylline often have to be treated with an antibiotic during acute stages. The purpose of the present study is to assess to clearance variation in theophylline when a macrolide antibiotic is associated after theophyllinemia steady-state has been attained. It has been seen that macrolides interfere differently on the blood levels of theophylline. Whereas erythromycin and josamycin determine a significant reduction in theophylline clearance, Miocamycin seems not to modify this parameter significantly.

Anti-Bacterial Agents↗
PubMed1989

[Diagnosis of choledocholithiasis and residual lithiasis. Ultrasonic postcholecystectomy].

246 patients with proven common bile duct stones at surgery were studied in order to establish the accuracy of ultrasound scanning in detecting choledocholithiasis and to compare the sensitivity of real-time examinations with those performed by a static scanner. The detection of choledocholithiasis by real-time ultrasound was 45.6% compared to 26.3% for the examinations performed with a static scanner. A dilated common bile duct was detected in 83.6% using real-time scanning compared to 70.3% using a static scanner. When the common bile duct was not dilated ultrasound was unable to detect the stones. Real-time ultrasound detected 66.6% of the patients with residual choledocholithiasis compared to 23.5% of patients examined by a static scanner. Our results show that real-time ultrasound scanning is a very useful screening method in detecting choledocholithiasis and residual lithiasis.

Cholecystectomy↗