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Biomedical subjects

P Moores

Publications and source records attributed to P Moores.

25 records · Page 2Linked to original sources
PubMedDate not supplied

S--s--U-- phenotype in the coloured population of Cape Town: problems encountered in paternity tests.

Two Cape Coloured persons of mixed White, Khoikhoi, Malay, Black parentage in Cape Town whole red cells were found to be S--s--U-- establish that the rare Su allele is present in this population group. The most likely source of the Su allele in them is the non-indigenous Black slaves who were brought to the Cape in the early years of White settlement there. In two paternity suits involving Cape Coloured persons, maternal and paternal exclusions were present unless the inheritance of an MSu or an NSu chromosome was postulated, and MS, NS and Ns chromosomes were seen to accompany He+ alleles in them.

Adolescent↗
PubMedDate not supplied

Severe hemolytic anemia in an adult associated with anti-T.

An adult woman hospitalized because of a stab wound suffered a severe hemolytic crisis during which she was found to be profoundly anemic. There was evidence of increased red blood cell fragility and extravascular hemolysis. Her cells, which were T-activated, were agglutinated spontaneously in vitro by anti-T in her own plasma. They were also agglutinated by some, but not all, human anti-M and anti-N sera, and were mildly aggregated by protamine sulphate. A normal amount of H antigen was present and no agglutination occurred in saline by incomplete Rh antibodies. The findings indicate that T-activation was incomplete. It is suggested that the patient experienced a short episode of acquired autohemolytic anemia caused by the activity of her own anti-T during a period when her normal enzyme-inhibiting substances were either not present or had been rendered temporarily inactive.

Adult↗
PubMedDate not supplied

Severe hemolytic disease of the newborn associated with anti-JSb.

The red blood cells of the group A infant of a group O central African Negro woman of the Zezuru tribe with anti-Lea and anti-JSb in her serum were found to be strongly agglutinated by a commerical antiglobulin reagent six days after birth. The high concentration of bilirubin in the infant's serum gradually decreased but he became profoundly anemic and, in the absence of a suitable donor, was successfully transfused with blood from his mother. Subsequent tests using the maternal anti-JSb diluted one in ten to avoid agglutination by the anti-Lea showed that the frequency of the JS(b-) phenotype in group O Zezuru is approximately one per cent.

ABO Blood-Group System↗