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Biomedical subjects

P Mogle

Publications and source records attributed to P Mogle.

At least 37 records · Page 2Linked to original sources
PubMed1986

Calcification of intervertebral disks in I-cell disease.

I-cell disease (ICD) is associated with skeletal dysplasia. However, changes of the intervertebral disks had not been previously reported. We describe a child with clinical and laboratory evidence of ICD who had multiple intervertebral disk calcifications. Since an excessive degeneration of the cartilage had previously been found in ICD, we propose that this process may give rise to calcification of the intervertebral disks in patients with ICD.

Calcinosis↗
PubMed1986

Perforation of the esophagus electrocardiographically mimicking myocardial infarction.

A 76-year-old woman developed a perforation of the median esophagus. A concomitant electrocardiographic follow-up was compatible with an acute anterior wall myocardial infarction, but was not accompanied by typical chest pain or elevated serum myocardial enzymes. Perforation of the esophagus is added to the list of diseases electrocardiographically imitating acute myocardial infarction.

Aged↗
PubMed1985

Pulmonary oedema following choking: report of two cases.

Two children, aged 3 1/2 and 5 1/2 years, are described. Both developed pulmonary oedema (PE) following a short episode of choking on a sweet and an orange, respectively. On admission diagnosis was made by chest X-ray. One child was asymptomatic despite PE while the other showed only mild respiratory distress. Both children recovered spontaneously and chest X-rays showed a return to normal within 24 h. The mechanism of PE production is discussed. It is suggested that oedema formation occurs during the obstruction and that it is due to hypoxia and the severe negative pleural pressure resulting from attempts to inspire against the obstructed airway. both hypoxia and severe negative pleural pressure cause an increase in pulmonary capillary pressure and transduration of fluid across the capillary membrane.

Airway Obstruction↗
PubMed1985

Meconium plugs and intussusception in a premature infant.

Neonatal intussusception in premature infants is uncommon and may mimic other abdominal disorders. We present a case of intussusception in a very low birthweight neonate. Presenting signs initially suggested necrotizing enterocolitis and meconium disease, and the diagnosis was confirmed at laparotomy.

Humans↗
PubMed1985

Respiratory failure and multiple fractures in vitamin D-dependent rickets.

A 20-month-old boy presented with multiple fractures and respiratory failure. He was found to have vitamin D-dependent rickets. The rickets did not improve with phosphate, calcium and calciferol. The rickets healed, however, with large doses of 1-alpha-hydroxycholecalciferol. The presentation is unusual and the response to therapy suggests metabolic heterogeneity in vitamin D-dependent rickets.

Bone Resorption↗
PubMed1985

Tracheo-oesophageal anomalies in the Goldenhar anomalad.

A case of the Goldenhar anomalad is presented with a previously undescribed association with oesophageal atresia and tracheo-oesophageal fistula. This is the second instance of a tracheobronchial-oesophageal communication being found in association with the anomalad. Awareness of this combination may facilitate future diagnosis and treatment of the anomaly.

Esophageal Atresia↗
PubMed1985

Strangulated congenital diaphragmatic hernia in infants.

Two previously healthy children, 7 and 12 months old, respectively, presented with respiratory distress and severe sepsis. Chest x-rays were suggestive of inflammatory disease of the left lung. At operation, necrotic bowel was found to be herniated through a left congenital posterolateral diaphragmatic hernia. These patients illustrate the difficulty in establishing the diagnosis of strangulated congenital diaphragmatic hernia and the grave consequences when operation is delayed.

Age Factors↗
PubMed1985

Multiple epiphysial dysplasia in one family. A further review of seven generations.

A family of 114 people in six generations, of whom 45 were affected by multiple epiphysial dysplasia, was described in this Journal in May 1960. We have been able to review them again 23 years later, and also to report on the type and incidence of the disease in more children and in a further generation. The relative severity of the disease in different branches of the family has been unchanged through the generations. Patients who were previously hopelessly crippled can today be rehabilitated by total hip replacement. Genetic counselling and birth control have reduced the relative and absolute numbers of affected children; this is tending to make the disease self-limiting.

Adolescent↗
PubMed1985

Near drowning in the dead sea. Electrolyte imbalances and therapeutic implications.

Unusual serum electrolyte abnormalities developed in eight patients who nearly drowned (ND) in the Dead Sea. Elevations in serum calcium and magnesium levels in particular required specific therapeutic intervention. The Dead Sea has a uniquely high concentration of calcium, magnesium, sodium, potassium, and chloride. The unusual serum electrolyte elevation that was observed in the ND victims in the Dead Sea apparently reflected the large solute load to which they were exposed. Four patients died subsequent to ND. Near drowning in the Dead Sea therefore represents a clinical entity that is associated with a high fatality rate and in which unrecognized major electrolyte abnormalities, in addition to the known respiratory complications, may influence the outcome.

Aged↗
PubMed1985

Corrosive injury to the stomach due to acid ingestion.

Ingestion of acid often causes severe damage to the stomach. Ingestion of alkali, however, usually injures the esophagus and spares the stomach. Early complications of acid ingestion, e.g., massive gastric hemorrhage or perforation, are unusual. The absence of severe symptoms in most patients soon after ingestion of acid is often misleading. Gastric outlet obstruction is a common late result and may develop following an asymptomatic interval. The authors' experience with three patients with severe complications following ingestion of acid is presented. The initial treatment, as well as the surgical management, are discussed.

Adult↗
PubMed1985

Lower limb pain in thalassemia.

A group of 67 homozygous beta thalassemic patients was investigated for disturbances related to their lower limbs. Thirty-six patients presented a variety of complaints. Four distinct types of pain were found. Ischemic crampy muscle pain in 12 patients. Postural pulsating pain after activity or prolonged standing was described by 18 patients. High intraosseous pressure was found in a significant number of these patients. Post transfusion hemosiderosis producing synovitis was diagnosed in 2 patients. Four additional patients presented acute self-limiting episodes of pain. This pain was probably due to microfractures. Some patients presented a combination of various pain patterns.

Adolescent↗
PubMed1984

Idiopathic infantile arterial calcification: a case report and review of the literature.

Idiopathic infantile arterial calcification (IIAC) was diagnosed radiologically in an infant with sudden onset of heart failure. The clinical picture, radiological, laboratory and postmortem findings, are described in detail. There was no family history and a metabolic abnormality could not be detected. Calcifications of major arteries and particularly ligaments are pathognomonic radiologic signs of this condition but diagnosis of IIAC during life has been established only rarely. The value of early diagnosis is emphasised.

Calcinosis↗
PubMed1984

An experimental model of a submucosally tunnelled valve for the replacement of the ileo-cecal valve.

An enteric valve to prevent colonic content reflux and to prolong small bowel transit time was created by passing small bowel through a submucosal tunnel in the colon. Barium enema, Gl tract series, and iso- and antiperistaltic pressure measurements showed the valve to be of competence equal to the ileo-cecal valve. Late pathological examination revealed a patent valve with minimal scar formation. The optimal submucosal tunnel length was between 4 and 6 cm. This valve can, theoretically, increase the absorptive capacity in short bowel syndrome and may serve as a substitute for the critically important ileo-cecal valve.

Animals↗