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Biomedical subjects

P Moerman

Publications and source records attributed to P Moerman.

187 records · Page 11Linked to original sources
PubMedDate not supplied

An important subgroup of phyllodes tumors of the breast is characterized by rearrangements of chromosomes 1q and 10q.

From a study of 10 cases of our own and 13 cases of the literature, anomalies of chromosome 1q and 10q emerge as consistently occurring changes in an important subgroup of phyllodes tumors of the breast. Anomalies of chromosome 1 were the most frequent ones, with a gain of 1q material, and histologically the tumors in which these anomalies were found were low grade malignancies. Structural changes of 10q emerged as the second most frequent chromosome change.

Adult↗
PubMedDate not supplied

Carcinoid tumour of the thymus: a case report.

A primary carcinoid tumour of the thymus is a very uncommon mediastinal tumour. Such a tumour weighing 83 g was incidentally discovered in an otherwise healthy man, aged 47 years. The histopathology is discussed.

Carcinoid Tumor↗
PubMedDate not supplied

Association of bilateral renal dysplasia and congenital hepatic fibrosis.

A young baby with jaundice and failure to thrive was found to have severe chronic renal failure and chronic cholestatic liver disease. She was the first child of healthy unrelated parents and died at the age of three months. Autopsy revealed bilateral renal dysplasia and congenital hepatic fibrosis. This particular association of kidney and liver disease has only rarely been observed. It must be differentiated from autosomal recessive polycystic liver and kidney disease.

Biopsy↗
PubMedDate not supplied

Bronchioloalveolar carcinoma: long-term survival of 23 resected patients.

We studied 23 patients, who underwent resection for bronchioloalveolar carcinoma between 1975 and 1992. The predictive value of the radiologic features, TNM staging, histopathologic type and extent of resection were examined. There were 20 men and 3 women (13%) with a mean age of 58 years (32-72y). Of all patients, 18 (78.3%) were asymptomatic. At chest X-ray, 14 (61%) revealed a solitary nodule, 6 an infiltrative or pneumonic mass, one a cystic lesion, and two multinodular lesions. The actuarial five-year survival was 46 +/- 23%. When a lobectomy was performed for bronchioloalveolar carcinoma, survival was better than when a pneumonectomy was performed. None of the seven patients who underwent a pneumonectomy survived 5 years. The actuarial 5-year survival of the 16 lobectomies was 70 +/- 25%. There was no statistical difference in survival between the histopathologic types.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMedDate not supplied

Lymphangiomatosis of the body wall: a report of two cases associated with chylothorax and fatal outcome.

We report on two cases of an unusual but distinctive variant of lymphangiomatosis, presenting at birth with predominantly cutaneous involvement of the body wall and complicated by chylothorax. The lesion manifested clinically as a slowly progressive, diffuse, and fluctuant skin swelling. Eventually, almost the entire trunk became affected. There were no bone lesions. Histologically, the soft tissues were diffusely infiltrated by interconnecting mazelike lymphatic vessels. The two infants died from infection at the age of 23 days and 10 months, respectively. Our experience confirms that premortem histologic diagnosis of lymphangiomatosis is difficult to establish. Awareness of the condition and knowledge of its various clinical presentation forms are essential for proper recognition, assessment of the outcome, and evaluation of new therapeutic measures such as interferon.

Chylothorax↗