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Biomedical subjects

P Miossec

Publications and source records attributed to P Miossec.

At least 145 records · Page 8Linked to original sources
PubMed1983

Critical study of staging in multiple myeloma.

130 patients with multiple myeloma were reviewed for a retrospective study of their classification according to Durie & Salmon. No significant difference was found in survival between patients in stages I, II and III (median survival 24.8, 32.1, and 17.3 months, respectively). Of the classical criteria affecting survival, only the Hb level showed any significant influence (P less than 0.04). In accordance with this finding, the survival time was much shorter (P less than 0.001) in patients with renal failure than in patients without (median survival 7.4 and 24.8 months, respectively); in addition, thrombopenia, fever, old age, and above all, the % of bone-marrow plasmocytes present, were shown to be decisive factors.

Actuarial Analysis↗
PubMed1983

[Anti-perinuclear antibodies in the diagnosis and prognosis of rheumatoid polyarthritis].

Anti-perinuclear antibodies (APN) were studied in 547 subjects, 123 of whom suffered from rheumatoid polyarthritis (RP). They were detected 88 times in the latter group (72 percent). 26 percent of RP were without serological abnormalities when only rheumatoid factors were considered (latex, Waaler-Rose, Waaler-Rose LOR, rheumatoid factors by indirect immunofluorescence). The rate dropped to 10 percent when APN were included. This test is therefore sensitive. It is also specific as APN exists in only 11 percent of non-rheumatoid rheumatological diseases not including psoriasis (42 percent) and in 16 percent of other auto-immune diseases. In addition, there is a correlation (p less than 0.01) between APN level and the evolution of the rheumatoid illness. APN appears early in an illness and is thus of diagnostic and prognostic interest in RP.

Adolescent↗
PubMed1983

Analysis of lymphocyte subsets in the blood of rheumatoid arthritis patients: correlation with disease activity.

Various erythrocyte rosette forming cells (ERFC) were quantified in 111 patients with rheumatoid arthritis (RA): total-ERFC (t-RFC), active-ERFC (act-ERFC), autologous-ERFC (auto-ERFC) and high affinity erythrocyte-antibody rosette forming cells (EA-RFC). B lymphocytes were counted using a direct immunofluorescence method. A decrease in act-ERFC and an increase in high affinity EA-RFC was found, but only the levels of the former correlated with the degree of inflammation and may be regarded as an indicator of clinical activity. Conversely, numbers of t-ERFC, auto-ERFC and B lymphocytes were found to be approximately normal. There was no correlation between the level of act-ERFC and the presence of rheumatoid factor, circulating immune complexes or antinuclear antibodies.

Arthritis, Rheumatoid↗
PubMed1983

Relationship between rheumatoid arthritis and monoclonal gammopathy.

The incidence of monoclonal gammopathy (MG) developing after the onset of rheumatoid arthritis (RA) was found to be 4.1%. Comparison of 12 patients with both diseases and a group of 215 control cases of RA showed the age of onset of RA was higher when MG was going to develop. In such cases, MG was heralded by lower or diminishing serum rheumatoid factor titers. Comparison of these 12 patients with 971 control cases of MG showed the same high frequency of patients with IgM-MG as that recently reported for a series in Western France. An unusually high but not significant incidence of patients with lambda light chains was observed. The reasons for this remain to be elucidated.

Adult↗
PubMed1982

[Salivary lysozyme, immunoglobulins and beta 2-microglobulin in Gougerot-Sjögren syndrome].

Lysozyme (LZM), immunoglobulins and beta 2-microglobulin concentrations were measured in the saliva of 79 patients with primary (n = 29) or secondary (n = 50) Sjögren's syndrome and in a control population. beta 2-microglobulin and immunoglobulins A, G and M concentrations were higher, and LZM concentrations lower than in controls. A significant correlation was established between LZM and immunoglobulins, but no correlation was found between immunoglobulins and beta 2-microglobulin, nor between the latter and LZM. These results indicate that salivary LZM concentration may be of value in the diagnosis of Sjögren's syndrome.

Adult↗
PubMed1982

[Present status of primary Gougerot-Sjögren syndrome].

When primary and not part of a systemic autoimmune disease, Sjögren's syndrome has peculiar clinical, serological and genetic features. It exceptionally becomes malignant but evolves to a stage of pseudo-lymphoma. Numerous studies suggest hyperstimulation of B-lymphocytes that would result from destruction of suppressive T-lymphocytes, this destruction in turn being probably due to failure of immune complex clearing by the reticulo-endothelial system.

Antibodies, Antinuclear↗
PubMed1982

[Rheumatoid arthritis with monoclonal gammopathy. Retrospective review of twelve case-reports (author's transl)].

Monoclonal gammopathy (MG) occurs in the course of rheumatoid arthritis (RA) in approximately 3.7% of cases. Twelve such cases were compared to two-hundred and fifteen controls with RA. RA was of later onset in patients with MG. Patients with MG had lower latex and Rose-Waaler titers; a decrease in these titres heralded onset of MG. The twelve patients with both RA and MG were then compared to nine-hundred and seventy-one controls with monoclonal gammopathy. As in previous studies, we recorded both IgM excess and unexplained lambda light chain excess.

Aged↗
PubMed1982

Clinical relevance of antikeratin antibodies in rheumatoid arthritis.

Antikeratin antibodies (AKA) were found in 38 out of 96 patients with rheumatoid arthritis (RA); they appeared to be quite characteristic to this disease. There was a very low incidence of AKA positivity in the control groups, i.e., 1 out of 62 healthy subjects and 4 out of 158 other patients. With regard to the sensitivity of the test as a diagnostic tool, AKA was found to be weaker than the rheumatoid factor (RF) and the antiperinuclear factor (APF), whereas the specificity was much better than APF and RF. A clear correlation was shown between the titres of AKA and APF (p less than 0.001) and also between AKA levels and inflammation (p less than 0.02).

Adult↗
PubMed1982

Levels of T lymphocytes, but not specific antibodies, reflect clinical presentation in human herpes simplex keratitis.

Total erythrocyte Rosette-forming cells (ERFC) have been found to be decreased in 44 patients with recurrent ocular herpes but normal in 26 patients with the primary form of the disease. Active ERFC have been found to be decreased in 27 patients with herpetic keratouveitis and normal in 43 patients with superficial herpetic keratitis. Antibodies to herpes simplex virus could not be used to distinguish the various clinical presentations of the disease.

Adolescent↗
PubMed1982

[Antiperinuclear factors in psoriasis. Correlation with other serological abnormalities in 90 patients].

Antiperinuclear factors (APF), studied in 90 patients suffering from psoriasis, were found in psoriasis without arthritis, in psoriasis with psoriatic arthritis and in psoriasis with true rheumatoid arthritis (RA): respectively 57, 36 and 43 p. 100. Patients with APF did not differ from patients without APF apart form rheumatoid factors detected by indirect immunofluorescence. They were much more frequent in psoriasis with APF. These results are compared with those of RA. They lead to look for other auto-antibodies in psoriasis.

Adolescent↗
PubMed1982

[Ocular herpes. Correlations between subpopulations of T lymphocytes and clinical manifestations?].

Herpes simplex virus can affect the cornea in many ways, the main differences concerning the evolutive stage and the severity. Using the rosettes technique, we have tried to know if the study of the T lymphocytes subsets may give some help in foreseeing the risk of stromal or recurrent keratitis. Peripheral lymphocytes and T lymphocytes subsets: total E, E-active, autologous rosettes forming cells (E, E-act., auto-RFC) were studied among 60 patients with different clinical manifestations of herpetic keratitis: i.e. 27 epithelial and 23 stromal ones, 20 primary and 40 recurrent keratitis. Two groups of patients were found to have decreased levels of one T lymphocytes subset: the stromal ones with the most serious prognosis had above all a E-act--RFC decrease (16,5 +/- 8,5% vs 24,1 +/- 4,7 for the controls, p 0,001); the recurrent ones had above all a E-RFC decrease (53,6 +/- 6,4% vs 63,7 +/- 8,7 for the controls, p less than 0,001). So the most severe herpetic keratitis: recurrent and stromal ones seem to have cellular immunity abnormalities that are not found in the superficial or primary keratitis.

Adolescent↗
PubMed1982

[Rheumatoid arthritis with IgE type rheumatoid factors].

IgE class rheumatoid factors (IgE RF) were sought by indirect immunofluorescence (IFI) in 107 cases of rheumatoid arthritis (RA). They were found at a level of 1/2 in 34 per cent of cases and 1/10 in 16 per cent of cases. From a laboratory standpoint, RA with IgE RF is characterized by the presence in a statistically larger number of cases as well as in larger amounts of agglutinating RF. There is no correlation between IgE RF levels and serum IgE levels. From the clinical standpoint, RA with IgE RF is characterized only by its more advanced state. The presence of abarticular manifestations is far from constant and is no more common than in RA without IgE RF.

Adult↗
PubMed1982

Analysis of criteria in staging in multiple myeloma.

One hundred and thirty patients suffering from multiple myeloma were reviewed for retrospective study of their classification according to Durie and Salmon's staging system. No significant difference was found in survival between patients in stage I, II and III. Since then, each criterion developed by Durie and Salmon was evaluated separately. Only the Hb level showed a significant influence; a Hb level under 8.5 g/dl or corrected calcaemia above 3 mmol/l were never found separately. When survival according to the number of criteria was considered there was no difference. These findings agree with the well-founded classification of Durie and Salmon but the real importance of each criteria is questionable.

Calcium↗
PubMed1982

[Prognostic significance of lymphocytes forming "active rosettes" in lung cancer].

Lymphocytes forming E rosettes, active E, autologous and EA antibodies were studied in 66 subjects (56 men, 10 women, mean age 59, range: 40-85 years) who presented with lung cancer classified on the TMN scale in stages I and II: 19; stage III: 20; stage IV: 27. In comparison to the controls, there was a significant reduction (p less than 0.01) in E, autologous and EA rosettes in the patients. A reduction in E active rosettes (compared to controls) was noted for stage IV cases (p less than 0.01) and rose with the stage. The formation of rosettes was reduced in 50 squamous carcinomas compared to 12 anaplastic carcinomas for E rosettes (p less than 0.01) and E active (p less than 0.02). If one compares the actuarial survival curves of 37 patients with E act rosettes greater than or equal to 23% and of 29 with a level of less than 23%, the mean survival for all stages combined was 14.1 months in the first group and 8.2 months in the second group. Associated with an extension of the tumour, the immunological system has a role in determining outcome and lymphocytes forming active E rosettes appear to be the subpopulation most closely correlated with survival.

Adenocarcinoma↗