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Biomedical subjects

P Millard

Publications and source records attributed to P Millard.

10 recordsLinked to original sources
PubMed1992

Bullous and haemorrhagic lichen sclerosus with scalp involvement.

We describe a patient who developed a generalized blistering eruption due to lichen sclerosus and who was observed to have scalp involvement. Both are unusual manifestations of this disease which merit consideration. Lichen sclerosus is an uncommon disease that most frequently affects the external genitalia of perimenopausal women. The aetiology is unknown. Approximately 20% of affected patients have extragenital lesions that present as small, ivory, shiny round macules or papules that later become atrophic; extragenital lesions are generally asymptomatic. Bullous and haemorrhagic forms may occur but these are generally localized and reports of extensive or generalized involvement are rare. We describe an elderly woman with generalized bullous lichen sclerosus. As an incidental finding, she was observed to have lichen sclerosus affecting her scalp. This has rarely been described and it would appear that she is the third reported case of scalp involvement.

Aged↗
PubMed1991

Antenatal village stay and pregnancy outcome in rural Zimbabwe.

DESIGN: Comparative study of pregnancy outcome for parturients who had stayed in an antenatal village and for those admitted directly from the community. SETTING: A rural hospital in Zimbabwe. OUTCOME MEASURES: Birthweight, perinatal mortality and degree of obstetrical intervention. RESULTS: Women who stayed in the antenatal village experienced better pregnancy outcome than women admitted directly from the community. Birthweight was greater, perinatal mortality lower, and obstetrical intervention less often required in the antenatal village group. CONCLUSIONS: Lack of randomisation, differences between the two groups in antenatal risk factors, and lack of information relating to socio-economic status suggest that generalisations beyond the specific case be made cautiously.

Adult↗
PubMed1987

Inhibition of NK and ADCC activity by antibodies against purified cytoplasmic granules from rat LGL tumors.

Highly purified preparations of cytoplasmic granules from transplantable rat large granular lymphocyte (LGL) tumor lines (rat natural killer (RNK) tumors) were used to immunize rabbits. Antibodies from these animals gave two precipitin lines with granule extracts in Ouchterlony experiments. They reacted with at least four different bands on nitrocellulose blots of SDS gels of LGL granule proteins. By immunofluorescence, specifically adsorbed antigranule antibodies did not recognize LGL or T cell surface antigens but reacted with the cytoplasmic granules in permeabilized RNK tumor cells as well as with normal rat LGL. These same antisera showed little or no reactivity with a panel of other cells, including peripheral blood T cells, thymocytes, macrophages, and EL-4 tumor cells. F(ab')2 preparations of these antigranule antibodies completely blocked granule-mediated lysis of both SRBC and nucleated targets, while control F(ab')2 preparations from rabbits immunized with EL-4 granules or TNP-KLH showed no significant inhibition of this cytolytic activity at the same antibody concentration. Anti-granule F(ab')2 preparations specifically inhibited (greater than 75%) rat natural killer (NK) and antibody-dependent cellular cytotoxicity (ADCC) activities in a dose-dependent manner but did not effect cytotoxic T cell activity. Pretreatment of either effectors or targets by these antibodies had no effect. Anti-granule F(ab')2 preparations, at concentrations showing strong inhibition of lysis, did not inhibit the binding of LGL to YAC-1 or Ab-coated P815 targets. These results demonstrate that a granule component(s) is necessary for the lytic activity of LGL in both NK and ADCC and provide the first direct evidence that a secretory event involving these granules is part of the lytic process.

Animals↗
PubMed1985

Prediction of the conformation and antigenic determinants of the V-sis viral oncogene product homologous with human platelet-derived growth factor.

In an extensive study involving unification of secondary structure prediction methods to predict peptide backbone angles, folding simulations, and interactive graphics we have calculated conformations for a 160 residue p28sis protein fragment. We demonstrate that the state of the art is sufficient to aid artificial vaccine design.

Antigens, Viral↗