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Biomedical subjects

P Merkle

Publications and source records attributed to P Merkle.

71 records · Page 4Linked to original sources
PubMed1976

[Agastric dystrophy after gastrectomy].

A follow-up of 9 patients was performed 5-11 years subsequent to total gastrectomy. Biochemical findings were normal. Compared to a normal control group vitamin A absorption indicative of fat assimilation was unaltered. Subjects regained preoperative weight and presented no signs of malnutrition. Eight patients suffered seriously from reflux. Five patients showed dumping symptoms. Endoscopic specimens from jejunal mucosa were found to be normal. It seems that postoperative complaints described above may be prevented by reasonable operative measures.

Aged↗
PubMed1976

[Preliminary observations on the clinical use of calcitonin. Treatment and postoperative prevention of pancreatitis].

Calcitonin was administered to 4 patients presenting with acute pancreatitis as well as to 6 patients presenting with postoperative pancreatitis. Prophylactic administration was performed in 3 cases consecutive to pancreatic interventions. Following calcitonin all patients showed considerable improvement of clinical course. Although 8 patients recuperated completely 2 patients died from independent complications. After prophylactic administration of calcitonin the postoperative course was uncomplicated without demonstrable increase in serum amylase. It is emphasized that only early case histories are reported; their verification will depend upon the results of a controlled survey presently being performed.

Acute Disease↗
PubMed1976

[Modification of postoperative intestinal atony using caerulein. Comparative studies in the rat and man].

The effect of caerulein upon postoperative enteral paralysis was investigated in animals and men. The increase in motility effected by cerulein in rats was proved by the increase in passage demonstrated after administration of radioactive test food (51CrO4Na2 solution). A clinical survey comprising 20 patients in the postoperative period following cholecystectomy, compared to an untreated control group, confirmed our findings.

Animals↗
PubMed1975

[Functional and metabolic changes of the mucosa during the occlusion of the small bowel of the rat (author's transl)].

In this study we investigated the function of the obstructed small bowel of the rat, the behaviour of the mucosal enzymes, the metabolic changes of the small bowel wall and the morphology of the mucosa. We found a decrease of passive transport of 3H-Antipyrine which was equal after 24 and 48 hrs. The active transport of 14C-Glucose was found to be progressively inhibited after occlusion. The metabolic enzymes SDH, G-6-PDH, and GOT remained unchanged, LDH was increased after 48 hrs, which can be explained by enzyme induction. The lactate-pyruvate ratio in the tissue of the obstructed bowel was 3 times as high as in the controls. The brush-border enzymes maltase and especially the alkaline phosphatase are decreased with progressive obstruction, which probably is caused by diffusion into the lumen. By electron-microscopy there are no changes in the brush-border membrane but a swelling of mitochondria which is caused by hypoxia.

Alkaline Phosphatase↗
PubMed1975

[Clinical picture and treatment of carcinoid of the appendix].

The clinical syndrome of a carcinoid tumor of the appendix is presented in 7 such cases. In spite of its slow growth and late metastatic dissemination iliocoecal resection must be performed dependent on the extent and location of the tumor.

Adolescent↗
PubMed1975

[Animal experiments on absorption and blood circulation in a mechanical ileus of the small intestine].

Using the perfusion technique the absorption of glucose, water and sodium was studied in the obstructed bowel. When the obstruction was reversed, the decreased absorption of glucose normalized after 24 hrs., of water and sodium after 36 hrs. The intraluminal pressure does not alter the capillary circulation during obstruction. Histologically an edema of the bowel wall and impaired venous flow was observed. In electronmicroscopic studies no morphological changes could be seen.

Animals↗
PubMedDate not supplied

Perioperative brachytherapy as an additional therapeutic option in patients with renal cell carcinoma (RCC), either inoperable or after completed percutaneous radiotherapy.

Between January 1992 and December 1997 60 patients with different tumors were treated with perioperative high dose rate brachytherapy with Iridium 192 in afterloading technique (HDR), total dosis 20-30 Gy. Three of the patients had RCC. These patients are presented in detail. In elected patients in whom other forms of treatment are not available or have failed, the method offers an additional therapeutic option and can achieve excellent results.

Aged↗