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Biomedical subjects

P Meredith

Publications and source records attributed to P Meredith.

46 records · Page 3Linked to original sources
PubMed1984

[Carpal tunnel syndrome--a leading symptom in generalized tendomyopathy].

Among 75 of 100 patients with generalized tendomyopathy, carpal-tunnel syndrome developed in the course of the disease and was demonstrated both clinically and electromyographically, requiring operative intervention in 10%. Furthermore, 17 of 26 patients previously operated on for carpal-tunnel syndrome, had chronic tendomyopathy requiring treatment, and in six there was severe generalized tendomyopathy. Thus generalized tendomyopathy can be the precipitating underlying disease in a large number of cases with so-called idiopathic carpal-tunnel syndrome.

Adult↗
PubMed1980

Prevention of venous thromboembolism after total knee replacement by high-dose aspirin or intermittent calf and thigh compression.

A prospective study of patients undergoing total knee replacement was carried out by using a combination of 125I-fibrinogen scanning and phlebography, and showed a high incidence of venous thromboembolic disease (TE). Ventilation-perfusion lung scanning was performed to detect pulmonary emboli in most patients. High doses of aspirin and an intermittent low-pressure pneumatic compression device (IPCD) were effective, even in women, in preventing TE. Low doses of aspirin and placebo were equally ineffective in preventing TE. Lung-scan abnormalities compatible with pulmonary emboli were found in six out of 10 patients with isolated calf-vein thrombi. Conventional tests of platelet function did not predict the development of TE. No significant differences were found between the patients receiving low and high doses of aspirin with respect to the mean template bleeding time or platelet aggregation in response to adenosine diphosphate, collagen, and epinephrine, although these variables were significantly abnormal in the two groups receiving aspirin compared with those treated with placebo and the IPCD. Thus high doses of aspirin and a new low-pressure IPCD were effective in preventing venous TE in patients (predominantly women) undergoing total knee replacement.

Adult↗
PubMed1976

[Intermittent pneumatic compression of leg and thigh: a new successful method for the prevention of postoperative thrombosis].

In a prospective study, 54 patients undergoing joint-replacement operations were randomized into a control and a treatment group. In the treatment group low pressure intermittent compression (Phlebo-Dynastat) to calves and thighs was started on the day of operation and continued until patients were fully mobilized. In 34 evaluable patients undergoing total hip arthroplasty the incidence of deep vein thrombosis (DVT) as determined by venography was 43% in the control group and 22% in the treatment group (p = 0.18). In 17 patients undergoing total knee replacement, DVT occurred postoperatively in 70% of the control group but in none of the treatment group (p = 0.002). The difference between the control and Phlebo-Dynastat group when comparing all patients was highly significant (p less than 0.005). Low pressure intermittent venous compression offers a welcome alternative method of thrombosis prophylaxis in patients with increased risk of bleeding.

Air Pressure↗
PubMed1975

Age-related changes, including synergy and suppression, in the mixed lymphocyte reaction in long-lived mice.

The mixed lymphocyte culture reaction represents the in vitro counterpart of the recognition phase of the graft-versus-host reaction, and of allograft rejection. The mixed lymphocyte culture reactivities of lymph node and spleen cells from all strains show a striking decline with advanced age. Furthermore, studies of "synergy" between subpopulations of T cells in the mixed lymphocyte culture reaction suggest that the cells of the recirculating lymphoid pool (T2 cells) in particular display a functional decline. Finally, spleen cells from old mice of appropriate strains inhibit or suppress the mixed lymphocyte culture reactivity of lymph node or spleen cells from young mice.

Aging↗
PubMedDate not supplied

Audit of patients' experiences after endoscopy of the upper alimentary tract.

This study comprises an audit of the experiences of upper alimentary endoscopy by 400 patients examined in 15 hospitals. The patients were asked to complete a 19-section questionnaire regarding their experience of the endoscopy before, during and after the procedure. The audit was carried out in order to evaluate the patients' understanding of the investigation and to determine the impact of the findings on the patients' level of anxiety. Of the 400 patients, 304 (76.0%) returned the questionnaire; overall satisfaction was revealed with the decision to proceed with endoscopy and with the procedure itself, as well as the reassurance provided by the investigation. The study thus supports the role of open-access endoscopy.

Adolescent↗